Metabolic and Systems Biology (TMED)

Research Output 1973 2019

31 Citations (Scopus)

Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses

Huo, Y., Guo, X., Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y. Y., Ong, K. T., Woo, S. L., Chapkin, R. S., Mashek, D. G., Chen, Y., Dong, H., Lu, F., Wei, L. & Wu, C., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 21492-21500 9 p.

Research output: Contribution to journal › Article

Phosphofructokinase-2
Nutrition
Liver
Transgenic Mice
Insulin Resistance
18 Citations (Scopus)

TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice

Call, J. A., Ervasti, J. M. & Lowe, D. A., Jul 1 2011, In : Journal of Applied Physiology. 111, 1, p. 200-205 6 p.

Research output: Contribution to journal › Article

Utrophin
Inbred mdx Mouse
Dystrophin
Knockout Mice
Food
14 Citations (Scopus)

T Cell-Expressed CD40L potentiates the bone anabolic activity of intermittent PTH treatment

Robinson, J. W., Li, J. Y., Walker, L. D., Tyagi, A. M., Reott, M. A., Yu, M., Adams, J., Weitzmann, M. N. & Pacifici, R., Apr 1 2015, In : Journal of Bone and Mineral Research. 30, 4, p. 695-705 11 p.

Research output: Contribution to journal › Article

CD40 Ligand
Stromal Cells
T-Lymphocytes
Bone and Bones
Parathyroid Hormone
132 Citations (Scopus)

The actin gene family: Function follows isoform

Perrin, B. J. & Ervasti, J. M., Oct 1 2010, In : Cytoskeleton. 67, 10, p. 630-634 5 p.

Research output: Contribution to journal › Article

Actins
Protein Isoforms
Genes
Mammals
Amino Acid Sequence
38 Citations (Scopus)

The atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated by distinct microcystin-sensitive and magnesium-dependent protein phosphatases

Bryan, P. M. & Potter, L. R., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 16041-16047 7 p.

Research output: Contribution to journal › Article

Atrial Natriuretic Factor Receptors
Phosphoprotein Phosphatases
Magnesium
Magnesium Chloride
Guanylate Cyclase
13 Citations (Scopus)

The carboxy-terminal third of dystrophin enhances actin binding activity

Henderson, D. M., Lin, A. Y., Thomas, D. D. & Ervasti, J. M., Feb 24 2012, In : Journal of Molecular Biology. 416, 3, p. 414-424 11 p.

Research output: Contribution to journal › Article

Dystrophin
Actins
Microfilament Proteins
Anisotropy
Actin Cytoskeleton
3 Citations (Scopus)

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

CGTP Collaborators, Dec 1 2019, In : British Journal of Pharmacology. 176, S1, p. S297-S396

Research output: Contribution to journal › Article

Open Access
Terminology
Pharmacology
Enzymes
Pharmaceutical Preparations
Ligands
15 Citations (Scopus)

The conserved cis-Pro39 residue plays a crucial role in the proper positioning of the catalytic base Asp38 in ketosteroid isomerase from Comamonas testosteroni

Nam, G. H., Cha, S. S., Yun, Y. S., Yun Hee, O. H., Hong, B. H., Lee, H. S. & Choi, K. Y., Oct 15 2003, In : Biochemical Journal. 375, 2, p. 297-305 9 p.

Research output: Contribution to journal › Article

Comamonas testosteroni
Ketosteroids
Isomerases
Catalytic Domain
Equilenin

The experimental use of cooperative learning groups in a biochemistry laboratory course for first-year medical students

Roon, R. J., Van Pilsum, J. F., Harris, I., Rosenberg, P., Johnson, R., Liaw, C. & Rosenthal, L., Jan 1983, In : Biochemical Education. 11, 1, p. 12-15 4 p.

Research output: Contribution to journal › Article

Biochemistry
Students

The galaxy platform for reproducible affinity proteomic mass spectrometry data analysis

Stewart, P. A., Kuenzi, B. M., Mehta, S., Kumar, P., Johnson, J. E., Jagtap, P. D., Griffin, T. J. & Haura, E. B., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 249-261 13 p. (Methods in Molecular Biology; vol. 1977).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Galaxies
Proteomics
Mass Spectrometry
Workflow
Software

The human saliva proteome: Overview and emerging methods for characterization

Griffin, T. J., Jan 1 2015, Advances in Global Health Through Sensing Technologies 2015. Southern, S. O., Gartner, C., Stallings, J. D. & Rodriguez-Chavez, I. R. (eds.). SPIE, Vol. 9490. 949003

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

proteome
saliva
Proteome
emerging
proteins
7 Citations (Scopus)

The indolocarbazole, Gö6976, inhibits guanylyl cyclase-A and -B

Robinson, J. W., Lou, X. & Potter, L. R., Sep 1 2011, In : British Journal of Pharmacology. 164, 2 B, p. 499-506 8 p.

Research output: Contribution to journal › Article

Guanylate Cyclase
C-Type Natriuretic Peptide
3T3-L1 Cells
atrial natriuretic factor receptor A
Natriuretic Peptides

The proteome of human saliva

Griffin, T. J., Aug 12 2013, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III. 87230A. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 8723).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

proteome
saliva
Proteome
Proteins
Protein
3 Citations (Scopus)

The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate

Edmund, A. B., Walseth, T. F., Levinson, N. M. & Potter, L. R., Jan 29 2019, In : Science Signaling. 12, 566, aau5378.

Research output: Contribution to journal › Article

Guanylate Cyclase
Catalytic Domain
Adenosine Triphosphate
Substrates
Phosphotransferases
329 Citations (Scopus)

The role of lipid droplets in metabolic disease in rodents and humans

Greenberg, A. S., Coleman, R. A., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., Yan, Q. W., Miyoshi, H. & Mashek, D. G., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2102-2110 9 p.

Research output: Contribution to journal › Review article

Metabolic Diseases
Rodentia
Lipids
Cholesterol Esters
Lipid Metabolism
17 Citations (Scopus)

The role of the proteasome in AML

Csizmar, C. M., Kim, D. H. & Sachs, Z., Dec 2 2016, In : Blood cancer journal. 6, 12, p. e503

Research output: Contribution to journal › Review article

Proteasome Endopeptidase Complex
Acute Myeloid Leukemia
Hematologic Neoplasms
Molecular Targeted Therapy
Mantle-Cell Lymphoma

The Sixth Annual Translational Stem Cell Research Conference of the New York Stem Cell Foundation

Marshall, C., Hua, H., Shang, L., Ding, B. S., Zito, G., de Peppo, G. M., Wang, G. K., Douvaras, P., Sproul, A. A., Paull, D., Fossati, V., Nestor, M. W., Mckeon, D., Smith, K. A. & Solomon, S. L., May 2012, In : Annals of the New York Academy of Sciences. 1255, 1, p. 16-29 14 p.

Research output: Contribution to journal › Article

Stem Cell Research
Translational Medical Research
Stem cells
Stem Cells
Posters
74 Citations (Scopus)

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Park, J-M., Jung, C. H., Seo, M., Otto, N. M., Grunwald, D. S., KIM, KWAN. HYUN., Moriarity, B. S., Kim, Y-M., Starker, C., Nho, R. S., Voytas, D. F. & Kim, D-H., Apr 5 2016, In : Autophagy. 12, 3, p. 547-564 18 p.

Research output: Contribution to journal › Article

Autophagy
Starvation
Phosphorylation
Food
Class III Phosphatidylinositol 3-Kinases
2 Citations (Scopus)

The Underpinnings of PNPLA3-Mediated Fatty Liver Emerge

Shang, L. & Mashek, D. G., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journal › Comment/debate

Fatty Liver
12 Citations (Scopus)

The ZZ domain of dystrophin in DMD: Making sense of missense mutations

Vulin, A., Wein, N., Strandjord, D. M., Johnson, E. K., Findlay, A. R., Maiti, B., Howard, M. T., Kaminoh, Y. J., Taylor, L. E., Simmons, T. R., Ray, W. C., Montanaro, F., Ervasti, J. M. & Flanigan, K. M., Feb 1 2014, In : Human mutation. 35, 2, p. 257-264 8 p.

Research output: Contribution to journal › Article

Dystroglycans
Dystrophin
Duchenne Muscular Dystrophy
Missense Mutation
Mutation
12 Citations (Scopus)

Thio-NADP Is Not an Antagonist of NAADP

Dickey, D. M., Aarhus, R., Walseth, T. F. & Lee, H. C., Jan 1 1998, In : Cell biochemistry and biophysics. 28, 1, p. 63-73 11 p.

Research output: Contribution to journal › Article

Drug Contamination
Cyclic ADP-Ribose
Synthetic Resins
Anion Exchange Resins
Adenosine Diphosphate Ribose
4 Citations (Scopus)

Three-dimensional peptide fractionation for highly sensitive nanoscale LC-based shotgun proteomic analysis of complex protein mixtures

Bandhakavi, S., Markowski, T. W., Xie, H. & Griffin, T. J., Nov 10 2011, Nanoproteomics: Methods and Protocols. Toms, S. & Weil, R. (eds.). p. 47-56 10 p. (Methods in Molecular Biology; vol. 790).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Firearms
Complex Mixtures
Proteomics
High Pressure Liquid Chromatography
Peptides
15 Citations (Scopus)

TNF-α drives matrix metalloproteinase-9 in squamous oral carcinogenesis

Hohberger, L., Wuertz, B. R. K., Xie, H., Griffin, T. J. & Ondrey, F. G., Aug 1 2008, In : Laryngoscope. 118, 8, p. 1395-1399 5 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinase 9
Carcinogenesis
Tumor Necrosis Factor-alpha
Mouth Neoplasms
Tetradecanoylphorbol Acetate
13 Citations (Scopus)

Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells

Mamedova, L. K., Yuan, K., Laudick, A. N., Fleming, S. D., Mashek, D. & Bradford, B. J., Aug 1 2013, In : Journal of Nutritional Biochemistry. 24, 8, p. 1499-1507 9 p.

Research output: Contribution to journal › Article

Toll-Like Receptor 4
Palmitates
Gene expression
Hepatocytes
Carcinoma
42 Citations (Scopus)

Trade-off between high sensitivity and increased potential for false positive peptide sequence matches using a two-dimensional linear ion trap for tandem mass spectrometry-based proteomics

Xie, H. & Griffin, T. J., Apr 1 2006, In : Journal of Proteome Research. 5, 4, p. 1003-1009 7 p.

Research output: Contribution to journal › Article

Tandem Mass Spectrometry
Proteomics
Mass spectrometry
Ions
Peptides
9 Citations (Scopus)

Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure

Shepherd, S. O., Strauss, J. A., Wang, Q., Dube, J. J., Goodpaster, B., Mashek, D. G. & Chow, L. S., Aug 15 2017, In : Journal of Physiology. 595, 16, p. 5587-5601 15 p.

Research output: Contribution to journal › Article

Nonesterified Fatty Acids
Lipids
Muscles
Triglycerides
Fatty Acids
20 Citations (Scopus)

Training status diverges muscle diacylglycerol accumulation during free fatty acid elevation

Chow, L. S., Mashek, D. G., Austin, E., Eberly, L. E., Persson, X. M., Mashek, M. T., Seaquist, E. R. & Jensen, M. D., Jul 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 1, p. E124-E131

Research output: Contribution to journal › Article

Diglycerides
Nonesterified Fatty Acids
Insulin Resistance
Lipids
Ceramides
1 Citation (Scopus)

Trans fats: foods, facts, and biology.

Young, S. & Mashek, D., Jan 1 2008, In : Minnesota medicine. 91, 10, p. 41-44 4 p.

Research output: Contribution to journal › Article

Trans Fatty Acids
Fats
Food
Federal Government
Chronic Disease
16 Citations (Scopus)

Transgenic overexpression of γ-cytoplasmic actin protects against eccentric contraction-induced force loss in mdx mice

Baltgalvis, K. A., Jaeger, M. A., Fitzsimons, D. P., Thayer, S. A., Lowe, D. A. & Ervasti, J. M., Oct 13 2011, In : Skeletal Muscle. 1, 1, 32.

Research output: Contribution to journal › Article

Inbred mdx Mouse
Actins
Skeletal Muscle
Calcium
Muscles

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity

Foo, K. S., Skowronski, A. A., Baum, D., Firdessa-Fite, R., Thams, S., Shang, L., Creusot, R. J., LeDuc, C. A., Egli, D. & Leibel, R. L., Dec 1 2019, In : Scientific reports. 9, 1, 4965.

Research output: Contribution to journal › Article

Open Access
Inbred NOD Mouse
Fishes
Insulin
Autoimmunity
Epitopes

Transport and metabolic effect of α-aminoisobutyric acid in Saccharomyces cerevisiae

Kim, K. W. & Roon, R. J., Jan 1 1982, In : Federation Proceedings. 41, 4, p. No. 5239

Research output: Contribution to journal › Article

Saccharomyces cerevisiae
2-aminoisobutyric acid
8 Citations (Scopus)

Transport and metabolic effects of α-aminoisobutyric acid in saccharomyces cerevisiae

Kim, K. W. & Roon, R. J., Nov 24 1982, In : BBA - General Subjects. 719, 2, p. 356-362 7 p.

Research output: Contribution to journal › Article

Aminoisobutyric Acids
Yeast
Saccharomyces cerevisiae
Nitrogen
Asparaginase
5 Citations (Scopus)

Transport and metabolism of N-δ-chloroacetyl-l-ornithine by Saccharomyces cerevisiae

Larimore, F. S., Kuisk, I., Korkowski, P. M. & Roon, R. J., Jan 1 1980, In : Archives of Biochemistry and Biophysics. 204, 1, p. 234-240 7 p.

Research output: Contribution to journal › Article

Ornithine
Metabolism
Yeast
Saccharomyces cerevisiae
Amino Acid Transport Systems

Transport and metabolism of N-δ-chloroacetyl-L-ornithine by Saccharomyces cerevisiae

Larimore, F. S. & Roon, R. J., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journal › Article

Saccharomyces cerevisiae
N-delta-chloroacetyl-L-ornithine
11 Citations (Scopus)

Transverse tubule calcium regulation in malignant hyperthermia

Ervasti, J. M., Mickelson, J. R. & Louis, C. F., Mar 1989, In : Archives of Biochemistry and Biophysics. 269, 2, p. 497-506 10 p.

Research output: Contribution to journal › Article

Malignant Hyperthermia
Calcium
Muscle
Permeability
Skeletal Muscle
7 Citations (Scopus)

Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease

Gulcev, M., Reilly, C., Griffin, T. J., Broeckling, C. D., Sandri, B. J., Witthuhn, B. A., Hodgson, S. W., Woodruff, P. G. & Wendt, C. H., Sep 29 2016, In : International Journal of COPD. 11, 1, p. 2435-2446 12 p.

Research output: Contribution to journal › Article

Tryptophan
Chronic Obstructive Pulmonary Disease
Indoleamine-Pyrrole 2,3,-Dioxygenase
Metabolomics
Mass Spectrometry
20 Citations (Scopus)

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

Park, J-M., Seo, M., Jung, C. H., Grunwald, D., Stone, M., Otto, N. M., Toso, E., Ahn, Y., Kyba, M., Griffin, T. J., Higgins, L. & Kim, D-H., Apr 3 2018, In : Autophagy. 14, 4, p. 584-597 14 p.

Research output: Contribution to journal › Article

Open Access
Autophagy
Phosphotransferases
Phosphorylation
Starvation
Amino Acids
1085 Citations (Scopus)

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

Jung, C. H., Jun, C. B., Ro, S. H., Kim, Y. M., Otto, N. M., Cao, J., Kundu, M. & Kim, D. H., Apr 1 2009, In : Molecular biology of the cell. 20, 7, p. 1992-2003 12 p.

Research output: Contribution to journal › Article

Autophagy
Sirolimus
Starvation
Leucine
Phosphorylation
1 Citation (Scopus)

Unconventional secretion of adipocyte fatty acid binding protein 4 is mediated by autophagic proteins in a sirtuin-1-dependent manner

Josephrajan, A., Hertzel, A. M., Bohm, E. K., McBurney, M. W., Imai, S. I., Mashek, D., Kim, D. H. & Bernlohr, D. A., Sep 1 2019, In : Diabetes. 68, 9, p. 1767-1777 11 p.

Research output: Contribution to journal › Article

Sirtuin 1
Fatty Acid-Binding Proteins
Adipocytes
Proteins
Blood Proteins
3 Citations (Scopus)

Update on the moFF Algorithm for Label-Free Quantitative Proteomics

Argentini, A., Staes, A., Grüning, B., Mehta, S., Easterly, C., Griffin, T. J., Jagtap, P. D., Impens, F. & Martens, L., Feb 1 2019, In : Journal of Proteome Research. 18, 2, p. 728-731 4 p.

Research output: Contribution to journal › Article

Proteomics
Labels
Search Engine
Peptides
Workflow
12 Citations (Scopus)

Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine

Barnidge, D. R., Krick, T. P., Griffin, T. J. & Murray, D. L., Nov 15 2015, In : Rapid Communications in Mass Spectrometry. 29, 21, p. 2057-2060 4 p.

Research output: Contribution to journal › Article

Immunoglobulin Light Chains
Ionization
Mass spectrometry
Desorption
Electrophoresis
3 Citations (Scopus)

Using Representational Difference Analysis to detect changes in transcript expression of Aiptasia genes after laboratory exposure to lindane

Morgan, M. B., Parker, C. C., Robinson, J. W. & Pierce, E. M., Apr 1 2012, In : Aquatic Toxicology. 110-111, p. 66-73 8 p.

Research output: Contribution to journal › Article

Cnidaria
Lindane
lindane
HCH
Anemone
9 Citations (Scopus)

Utilization of D asparagine by Saccharomyces cerevisiae

Dunlop, P. C., Roon, R. J. & Even, H. L., Dec 1 1976, In : Journal of Bacteriology. 125, 3, p. 999-1004 6 p.

Research output: Contribution to journal › Article

Asparagine
Asparaginase
Saccharomyces cerevisiae
Nitrogen
varespladib methyl
21 Citations (Scopus)

Utilization of the resolved l-isomer of 2-amino-6-phosphonohexanoic acid (l-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons

Schulte, M. K., Roon, R. J., Chalmers, D. J., Sunter, D. C. & Koerner, J. F., Jun 27 1994, In : Brain Research. 649, 1-2, p. 203-207 5 p.

Research output: Contribution to journal › Article

Quisqualic Acid
Pyramidal Cells
N-Methylaspartate
Organophosphonates
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
1 Citation (Scopus)

Variable cytoplasmic actin expression impacts the sensitivity of different dystrophin-deficient mdx skeletal muscles to eccentric contraction

Lindsay, A., Southern, W. M., McCourt, P. M., Larson, A. A., Hodges, J. S., Lowe, D. A. & Ervasti, J. M., Jul 1 2019, In : FEBS Journal. 286, 13, p. 2562-2576 15 p.

Research output: Contribution to journal › Article

Utrophin
Dystrophin
Muscle
Actins
Skeletal Muscle
12 Citations (Scopus)

Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins

Nelson, D. M., Lindsay, A., Judge, L. M., Duan, D., Chamberlain, J. S., Lowe, D. A. & Ervasti, J. M., Jun 15 2018, In : Human molecular genetics. 27, 12, p. 2090-2100 11 p.

Research output: Contribution to journal › Article

Open Access
Dystrophin
Microtubules
Phenotype
Muscles
Inbred mdx Mouse
87 Citations (Scopus)

Vascular endothelial growth factor up-regulates expression of receptor activator of NF-κB (RANK) in endothelial cells. Concomitant increase of angiogenic responses to rank ligand

Min, J. K., Kim, Y. M., Kim, Y. M., Kim, E. C., Gho, Y. S., Kang, I. J., Lee, S. Y., Kong, Y. Y. & Kwon, Y. G., Oct 10 2003, In : Journal of Biological Chemistry. 278, 41, p. 39548-39557 10 p.

Research output: Contribution to journal › Article

Endothelial cells
Vascular Endothelial Growth Factor A
Up-Regulation
Endothelial Cells
Ligands
48 Citations (Scopus)

Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations

Abbey, S. E. & Potter, L. R., Nov 8 2002, In : Journal of Biological Chemistry. 277, 45, p. 42423-42430 8 p.

Research output: Contribution to journal › Article

C-Type Natriuretic Peptide
Vasopressins
Protein Kinase C
Natriuretic Peptides
Calcium
4 Citations (Scopus)

Xanthine oxidase is hyper-active in Duchenne muscular dystrophy

Lindsay, A., McCourt, P. M., Karachunski, P., Lowe, D. A. & Ervasti, J. M., Dec 2018, In : Free Radical Biology and Medicine. 129, p. 364-371 8 p.

Research output: Contribution to journal › Article

Duchenne Muscular Dystrophy
Xanthine Oxidase
Inbred mdx Mouse
Dystrophin
Muscle
37 Citations (Scopus)

β-actin and fascin-2 cooperate to maintain stereocilia length

Perrin, B. J., Strandjord, D. M., Narayanan, P., Henderson, D. M., Johnson, K. R. & Ervasti, J. M., May 13 2013, In : Journal of Neuroscience. 33, 19, p. 8114-8121 8 p.

Research output: Contribution to journal › Article

Stereocilia
Actins
Auditory Hair Cells
Actin Cytoskeleton
fascin