Research Output 1973 2019

Carbonylated Proteins and Their Metabolic Regulation: Overview of Mechanisms, Target Proteins, and Characterization Using Proteomic Methods

Afiuni-Zadeh, S. & Griffin, T. J., Apr 20 2017, Protein Carbonylation: Principles, Analysis, and Biological Implications. wiley, p. 110-130 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbonylation
Proteins
Oxidative stress
Avidin
Biomarkers
170 Citations (Scopus)
Protein Carbonylation
Carbonylation
Fatty Acid-Binding Proteins
Adipocytes
Insulin Resistance
24 Citations (Scopus)

Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia

Wang, Q., Donthi, R. V., Wang, J., Lange, A. J., Watson, L. J., Jones, S. P. & Epstein, P. N., Jun 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 6

Research output: Contribution to journalArticle

Phosphofructokinase-2
Glycolysis
Phosphoric Monoester Hydrolases
Muscle Cells
Hypertrophy
8 Citations (Scopus)

Catalytically active guanylyl cyclase B requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism

Dickey, D. M., Edmund, A. B., Otto, N. M., Chaffee, T. S., Robinson, J. W. & Potter, L. R., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11385-11393 9 p.

Research output: Contribution to journalArticle

Glycosylation
Dwarfism
Guanylate Cyclase
Endoplasmic Reticulum
C-Type Natriuretic Peptide
15 Citations (Scopus)

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity

Arden, C., Trainer, A., De La Iglesia, N., Scougall, K. T., Gloyn, A. L., Lange, A. J., Shaw, J. A. M., Matschinsky, F. M. & Agius, L., Jul 1 2007, In : Diabetes. 56, 7, p. 1773-1782 10 p.

Research output: Contribution to journalArticle

Glucokinase
Cell Biology
Mutation
Green Fluorescent Proteins
Phosphofructokinase-2
1 Citation (Scopus)

Chapter 13: Using Galaxy for Proteomics

Guerrero, C. R., Jagtap, P. D., Johnson, J. E. & Griffin, T. J., Jan 1 2017, Proteome Informatics. Bessant, C. & Gaskell, S. J. (eds.). 5 ed. Royal Society of Chemistry, p. 289-320 32 p. (New Developments in Mass Spectrometry; vol. 2017-January, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

Galaxies
Mass spectrometry
Bioinformatics
Proteomics
Scalability
13 Citations (Scopus)

Characterization of a Dio-9-resistant strain of Saccharomyces cerevisiae

Roon, R. J., Larimore, F. S., Meyer, G. M. & Kreisle, R. A., Jan 15 1978, In : Archives of Biochemistry and Biophysics. 185, 1, p. 142-150 9 p.

Research output: Contribution to journalArticle

Yeast
Saccharomyces cerevisiae
Adenosine Triphosphatases
Protons
Yeasts
6 Citations (Scopus)

Characterization of an intronic hormone response element of the rat liver/skeletal muscle 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene

McFarlan, S. C., Zhang, Q., Miksicek, R. J. & Lange, A. J., Jul 17 1997, In : Molecular and Cellular Endocrinology. 129, 2, p. 219-227 9 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Response Elements
Liver
Muscle
Rats
43 Citations (Scopus)

Characterization of a Novel Ser-cisSer-Lys Catalytic Triad in Comparison with the Classical Ser-His-Asp Triad

Shin, S., Yun, Y. S., Koo, H. M., Kim, Y. S., Choi, K. Y. & Oh, B. H., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 24937-24943 7 p.

Research output: Contribution to journalArticle

amidase
Alanine
Cysteine
Substitution reactions
Sulfinic Acids
48 Citations (Scopus)

Characterization of two forms of asparaginase in Saccharomyces cerevisiae

Dunlop, P. C., Meyer, G. M., Ban, D. & Roon, R. J., Jan 1 1978, In : Journal of Biological Chemistry. 253, 4, p. 1297-1304 8 p.

Research output: Contribution to journalArticle

Asparaginase
Substrate Specificity
Thermodynamics
Yeast
Isoenzymes
18 Citations (Scopus)

Characterizing cardiac molecular mechanisms of mammalian hibernation via quantitative proteogenomics

Vermillion, K. L., Jagtap, P. D., Johnson, J. E., Griffin, T. J. & Andrews, M. T., Nov 6 2015, In : Journal of Proteome Research. 14, 11, p. 4792-4804 13 p.

Research output: Contribution to journalArticle

Hibernation
Galaxies
Sciuridae
Proteomics
Proteins
1 Citation (Scopus)

Chronic Obstructive Pulmonary Disease Phenotype Dictates Cancer-Promoting Stromal Gene Expression Programs

Wendt, C. H., Sandri, B. J., Masvidal, L., Murie, C., Bartish, M., Avdulov, S. V., Higgins, L., Markowski, T., Peterson, M., Bergh, J., Yang, P., Rolny, C., Limper, A. H., Griffin, T. J., Bitterman, P. B. & Larsson, O., Dec 1 2018, In : Annals of the American Thoracic Society. 15, 4, p. S290-S291

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Phenotype
Gene Expression
Neoplasms
Lung Neoplasms
29 Citations (Scopus)

Cloning, expression and chromosomal localization of a human testis 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene

Manzano, A., Pérez, J. X., Nadal, M., Estivill, X., Lange, A. J. & Bartrons, R., Mar 18 1999, In : Gene. 229, 1-2, p. 83-89 7 p.

Research output: Contribution to journalArticle

Testis
Organism Cloning
Isoenzymes
Genes
Complementary DNA
23 Citations (Scopus)

Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Ventura, F., Ambrosio, S., Bartrons, R., El-Maghrabi, M. R., Lange, A. J. & Pilkis, S. J., Apr 26 1995, In : Biochemical and Biophysical Research Communications. 209, 3, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Cloning
Organism Cloning
Brain
Catalytic Domain
11 Citations (Scopus)

CNP, cardiac natriuretic peptide?

Potter, L. R., May 1 2004, In : Endocrinology. 145, 5, p. 2129-2130 2 p.

Research output: Contribution to journalShort survey

C-Type Natriuretic Peptide
Natriuretic Peptides
1 Citation (Scopus)

Community-Driven Data Analysis Training for Biology

Galaxy Training Network, Jun 27 2018, In : Cell Systems. 6, 6, p. 752-758.e1

Research output: Contribution to journalArticle

Open Access
Biological Science Disciplines
Web Browser
Research Personnel
Explosions
Internet

Comparative Metaproteomics to Study Environmental Changes

Matallana-Surget, S., Jagtap, P. D., Griffin, T. J., Beraud, M. & Wattiez, R., Oct 29 2017, Metagenomics: Perspectives, Methods, and Applications. Elsevier Inc., p. 327-363 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aquatic ecosystems
Microorganisms
Ecosystems
Ecosystem
Workflow
Clostridium
Ethanol
Genes
Protein folding
Bacteria
65 Citations (Scopus)

Compound loss of muscleblind-like function in myotonic dystrophy

Lee, K. Y., Li, M., Manchanda, M., Batra, R., Charizanis, K., Mohan, A., Warren, S. A., Chamberlain, C. M., Finn, D., Hong, H., Ashraf, H., Kasahara, H., Ranum, L. P. W. & Swanson, M. S., Dec 2013, In : EMBO Molecular Medicine. 5, 12, p. 1887-1900 14 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
RNA
Skeletal Muscle
Myocardium
Myotonia
25 Citations (Scopus)

Context-dependent functional substitution of α-skeletal actin by γ-cytoplasmic actin

Jaeger, M. A., Sonnemann, K. J., Fitzsimons, D. P., Prins, K. W. & Ervasti, J. M., Jul 1 2009, In : FASEB Journal. 23, 7, p. 2205-2214 10 p.

Research output: Contribution to journalArticle

Actins
Substitution reactions
Muscle
Muscles
Transgenic Mice
5 Citations (Scopus)

Contribution of conserved amino acids at the dimeric interface to the conformational stability and the structural integrity of the active site in ketosteroid isomerase from Pseudomonas putida biotype B

Nam, G. H., Kim, D. H., Ha, N. C., Jang, D. S., Yun, Y. S., Hong, B. H., Oh, B. H. & Choi, K. Y., Jul 1 2003, In : Journal of Biochemistry. 134, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Ketosteroids
Isomerases
Pseudomonas putida
Structural integrity
Catalytic Domain
19 Citations (Scopus)
Phosphofructokinase-2
Fructose-Bisphosphatase
Glucokinase
Glycolysis
Hepatocytes
9 Citations (Scopus)

"Corination" of the proANP converting enzyme

Potter, L. R., Feb 1 2005, In : Cell Metabolism. 1, 2, p. 88-90 3 p.

Research output: Contribution to journalShort survey

Atrial Natriuretic Factor
Natriuretic Peptides
Cardiomegaly
Enzymes
Peptide Hydrolases

Corrigendum: Persistent upregulation of the β-Tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle (Human Molecular Genetics (2019) 28:7 (1117-1135) DOI: 10.1093/hmg/ddy418)

Randazzo, D., Khalique, U., Belanto, J. J., Kenea, A., Talsness, D. M., Olthoff, J. T., Tran, M. D., Zaal, K. J., Pak, K., Pinal-Fernandez, I., Mammen, A. L., Sackett, D., Ervasti, J. M. & Ralston, E., Jun 1 2019, In : Human molecular genetics. 28, 11, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Medical Genetics
Tubulin
Microtubules
Regeneration
Molecular Biology
5 Citations (Scopus)

Creatine kinase B is necessary to limit myoblast fusion during myogenesis

Simionescu-Bankston, A., Pichavant, C., Canner, J. P., Apponi, L. H., Wang, Y., Steeds, C., Olthoff, J. T., Belanto, J. J., Ervasti, J. M. & Pavlath, G. K., Jun 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 11, p. C919-C931

Research output: Contribution to journalArticle

Muscle Development
Myoblasts
Creatine Kinase
Skeletal Muscle Fibers
Actins
36 Citations (Scopus)

Crystal structure of the Gtr1pGTP-Gtr2pGDP protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion

Jeong, J. H., Lee, K. H., Kim, Y-M., Kim, D-H., Oh, B. H. & Kim, Y. G., Aug 24 2012, In : Journal of Biological Chemistry. 287, 35, p. 29648-29653 6 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Raptors
Guanosine Triphosphate
Crystal structure
Proteins
38 Citations (Scopus)

Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E., Kim, D-H., Jang, S. K., Suh, P. G., Houslay, M. D. & Ryu, S. H., Nov 1 2010, In : Molecular and cellular biology. 30, 22, p. 5406-5420 15 p.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Cyclic AMP
Second Messenger Systems
Transducers
mechanistic target of rapamycin complex 1
16 Citations (Scopus)

Cyclobutane quisqualic acid analogues as selective mGluR5a metabotropic glutamic acid receptor ligands

Littman, L., Tokar, C., Venkatraman, S., Roon, R. J., Koerner, J. F., Robinson, M. B. & Johnson, R. L., May 6 1999, In : Journal of Medicinal Chemistry. 42, 9, p. 1639-1647 9 p.

Research output: Contribution to journalArticle

Cyclobutanes
Quisqualic Acid
Glutamic Acid
Phosphatidylinositols
Ligands
52 Citations (Scopus)

Deep metaproteomic analysis of human salivary supernatant

Jagtap, P. D., Mcgowan, T., Bandhakavi, S., Tu, Z. J., Seymour, S., Griffin, T. J. & Rudney, J. D., Apr 1 2012, In : Proteomics. 12, 7, p. 992-1001 10 p.

Research output: Contribution to journalArticle

Proteome
Peptides
Proteins
Mouth Diseases
Selenomonas
44 Citations (Scopus)

Delayed embryonic development and impaired cell growth and survival in Actg1 null mice

Bunnell, T. M. & Ervasti, J. M., Sep 1 2010, In : Cytoskeleton. 67, 9, p. 564-572 9 p.

Research output: Contribution to journalArticle

Embryonic Development
Actins
Cell Survival
Growth
Growth Disorders
46 Citations (Scopus)
Natriuretic Peptides
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Neprilysin
Guanylate Cyclase
47 Citations (Scopus)

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes

Egbert, J. R., Shuhaibar, L. C., Edmund, A. B., Van Helden, D. A., Robinson, J. W., Uliasz, T. F., Baena, V., Geerts, A., Wunder, F., Potter, L. R. & Jaffe, L. A., Jan 1 2014, In : Development (Cambridge). 141, 18, p. 3594-3604 11 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Granulosa Cells
Guanylate Cyclase
Meiosis
24 Citations (Scopus)

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

Shuhaibar, L. C., Egbert, J. R., Edmund, A. B., Uliasz, T. F., Dickey, D. M., Yee, S. P., Potter, L. R. & Jaffe, L. A., Jan 1 2016, In : Developmental Biology. 409, 1, p. 194-201 8 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Guanylate Cyclase
Meiosis
Threonine
4 Citations (Scopus)

Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Shuhaibar, L. C., Robinson, J. W., Vigone, G., Shuhaibar, N. P., Egbert, J. R., Baena, V., Uliasz, T. F., Kaback, D., Yee, S. P., Feil, R., Fisher, M. C., Dealy, C. N., Potter, L. R. & Jaffe, L. A., Dec 4 2017, In : eLife. 6, e31343.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Guanylate Cyclase
Bone Development
Cyclic GMP
Bone
12 Citations (Scopus)

Derepression of asparaginase II during exponential growth of Saccharomyces cerevisiae on ammonium ion

Roon, R. J., Murdoch, M., Kunze, B. & Dunlop, P. C., Jan 1 1982, In : Archives of Biochemistry and Biophysics. 219, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Asparaginase
Asparagine
Glutamine
Ammonium Compounds
Yeast
13 Citations (Scopus)

Destabilization of the dystrophin-glycoprotein complex without functional deficits in α-dystrobrevin null muscle

Bunnell, T. M., Jaeger, M. A., Fitzsimons, D. P., Prins, K. W. & Ervasti, J. M., Jul 2 2008, In : PloS one. 3, 7, e2604.

Research output: Contribution to journalArticle

dystrophin
Dystrophin
Muscle
glycoproteins
Glycoproteins
75 Citations (Scopus)
Natriuretic Peptides
Peptide Receptors
Guanylate Cyclase
Atrial Natriuretic Factor
C-Type Natriuretic Peptide
42 Citations (Scopus)
Dystrophin
Missense Mutation
Thermodynamics
Actins
Duchenne Muscular Dystrophy
4 Citations (Scopus)

Disease-proportional proteasomal degradation of missense dystrophins

Talsness, D. M., Belanto, J. J. & Ervasti, J. M., Oct 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 40, p. 12414-12419 6 p.

Research output: Contribution to journalArticle

Dystrophin
Mutation
Frameshift Mutation
Missense Mutation
Phenotype
10 Citations (Scopus)

Disseminating metaproteomic informatics capabilities and knowledge using the galaxy-P framework

Blank, C., Easterly, C., Gruening, B., Johnson, J., Kolmeder, C. A., Kumar, P., May, D., Mehta, S., Mesuere, B., Brown, Z., Elias, J. E., Hervey, W. J., McGowan, T., Muth, T., Nunn, B. L., Rudney, J., Tanca, A., Griffin, T. J. & Jagtap, P. D., Mar 1 2018, In : Proteomes. 6, 1, 7.

Research output: Contribution to journalArticle

Open Access
Galaxies
Informatics
Workflow
Software
Microbiota
2 Citations (Scopus)

Distinct cancer-promoting stromal gene expression depending on lung function

Sandri, B. J., Masvidal, L., Murie, C., Bartish, M., Avdulov, S., Higgins, L. A., Markowski, T., Peterson, M., Bergh, J., Yang, P., Rolny, C., Limper, A. H., Griffin, T. J., Bitterman, P. B., Wendt, C. H. & Larsson, O., Aug 1 2019, In : American journal of respiratory and critical care medicine. 200, 3, p. 348-358 11 p.

Research output: Contribution to journalArticle

Gene Expression
Lung
Lung Neoplasms
Neoplasms
Sirolimus
33 Citations (Scopus)

Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes

Ro, S. H., Jung, C. H., Hahn, W. S., Xu, X., Kim, Y. M., Yun, Y. S., Park, J. M., Kim, K. H., Seo, M., Ha, T. Y., Arriaga, E. A., Bernlohr, D. A. & Kim, D. H., Dec 1 2013, In : Autophagy. 9, 12, p. 2103-2114 12 p.

Research output: Contribution to journalArticle

Autophagy
Lipid Metabolism
Adipocytes
Adipogenesis
Glucose

Distinct mechanical properties in homologous spectrin-like repeats of utrophin

Rajaganapathy, S., McCourt, J. L., Ghosal, S., Lindsay, A., McCourt, P. M., Lowe, D. A., Ervasti, J. M. & Salapaka, M. V., Dec 1 2019, In : Scientific reports. 9, 1, 5210.

Research output: Contribution to journalArticle

Open Access
Utrophin
Spectrin
Dystrophin
Dystroglycans
Connectin
48 Citations (Scopus)
Guanylate Cyclase-Coupled Receptors
Guanylate Cyclase
Ligands
Guanylate Cyclase-Activating Proteins
Atrial Natriuretic Factor Receptors
35 Citations (Scopus)
Natriuretic Peptides
Peptide Receptors
Guanylate Cyclase
Down-Regulation
Atrial Natriuretic Factor
2 Citations (Scopus)
Peroxiredoxin III
Adipocytes
Down-Regulation
Insulin
Oxidation
8 Citations (Scopus)

DRAGging amino Acid-mTORC1 signaling by SH3BP4

Kim, Y. M. & Kim, D. H., Jan 1 2013, In : Molecules and cells. 35, 1, p. 1-6 6 p.

Research output: Contribution to journalReview article

GTP Phosphohydrolases
Carrier Proteins
Amino Acids
Intercellular Signaling Peptides and Proteins
Tuberous Sclerosis
41 Citations (Scopus)

Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes

Payne, V. A., Arden, C., Wu, C., Lange, A. J. & Agius, L., Jul 1 2005, In : Diabetes. 54, 7, p. 1949-1957 9 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Fructose-Bisphosphatase
Glucokinase
Hepatocytes
Fructose
Open Access
Adiposity
Insulin Resistance
Young Adult
Population
Body Mass Index
4 Citations (Scopus)

Dynamic range compression: A solution for proteomic biomarker discovery?

Griffin, T. J. & Bandhakavi, S., Sep 1 2011, In : Bioanalysis. 3, 18, p. 2053-2056 4 p.

Research output: Contribution to journalReview article

Body fluids
Body Fluids
Biomarkers
Post Translational Protein Processing
Proteomics