Metabolic and Systems Biology (TMED)

Active

Predictive Models of Beryllium Sensitization and Chronic Beryllium Disease

Griffin, T. J. (PI), Jagtap, P. D. (CoI), Hoff, I. N. (Other Role), Mehta, S. P. (Other Role), Noren, B. E. (Other Role) & Weise, D. O. (Other Role)

NATIONAL JEWISH HEALTH, NIH NATL INST OF ENVIRON HEALTH SCIENCES

11/26/24 → 5/25/25

Project: Research project

Molecular Characterization of Progressive Pulmonary Sarcoidosis

Griffin, T. J. (PI), Perlman, D. M. (CoI), Bailey, M. P. (Other Role), DeGrote, M. (Other Role), Goodwin, T. A. (Other Role), Hoff, I. N. (Other Role), Jagtap, P. D. (Other Role), Mehta, S. P. (Other Role), Noren, B. E. (Other Role) & Viken, K. J. (Other Role)

NATIONAL JEWISH HEALTH, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

11/26/24 → 5/25/25

Project: Research project

Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients

Griffin, T. J. (PI)

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

8/15/24 → 7/31/25

Project: Research project

Mechanisms of autophagy and mTOR signaling

Kim, D.-H. (PI)

NIH NIGMS NATL INST OF GENERAL

8/15/24 → 7/31/25

Project: Research project

A rigorous validation of a novel host-microbe peptide panel for ovarian cancer early detection from routinely collected clinical samples

Griffin, T. J. (PI), Jagtap, P. D. (CoI) & Petersen, A. J. (CoI)

MN OVARIAN CANCER ALLIANCE

7/1/24 → 6/30/25

Project: Research project

The immunoPeptidoGenomic (iPepGen) informatics resource for immuno-oncology research

Griffin, T. J. (PI) & Jagtap, P. D. (Co-Principal Investigator)

NIH NATIONAL CANCER INSTITUTE (NCI)

6/1/24 → 5/31/27

Project: Research project

Cancer Center Support Grant

Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/24 → 1/31/29

Project: Research project

Structural and molecular determinants of micro-Dystrophin stability and efficacyOption 2

Ervasti, J. M. (PI) & Muretta, J. M. (CoI)

SAREPTA THERAPEUTICS, INC.

7/1/23 → 6/30/25

Project: Research project

Inflammatory and metabolic impact of acute overeating

Mashek, D. (PI)

UNIVERSITY OF MINNESOTA FOUNDATION, ALLEN FOUNDATION MICHIGAN

6/1/23 → 5/31/25

Project: Research project

The 11S-associated immunoproteasome in mitochondrial function and metabolic disorders

Kim, D.-H. (PI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

5/5/23 → 4/30/27

Project: Research project

Lipid droplets and the compartmentalization of subcellular metabolism

Mashek, D. (PI) & Puchner, E. (CoI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

2/1/23 → 1/31/27

Project: Research project

Microbiome-derived regulators of therapy-resistant colorectal tumors

Griffin, T. J. (PI), Jagtap, P. D. (CoI) & Subramanian, S. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

8/9/22 → 7/31/25

Project: Research project

Midwest Murine-Tissue Mapping Center (MM-TMC)

Robbins, P. D. (PI), Adeyi, O. (CoI), Bartolomucci, A. (CoI), Beckman, K. B. (CoI), Butterick, T. A. (CoI), Camell, C. (CoI), Dong, X. (CoI), Garbe, J. R. (CoI), Griffin, T. J. (CoI), Hwang, J. (CoI), Ikramuddin, S. (CoI), Mashek, D. (CoI), Nelson, A. C. (CoI), Niedernhofer, L. J. (CoI), Pengo, T. (CoI), Revelo, X. (CoI), Robbins, P. D. (CoI), Sanders, M. A. (CoI), Sarver, A. L. (CoI), Seelig, D. (CoI), Sun, R. (CoI), Temiz, N. A. (CoI), Walmsley, S. J. (CoI), Wang, J. (CoI), Williams, J. W. (CoI), Bernlohr, D. A. (Prior Principal Investigator) & Aliferis, MD, PhD, C. (Other Role)

NIH NAT'L INSTITUTE ON AGING (NIA)

8/2/22 → 7/31/26

Project: Research project

Enhancing Treg Therapeutic Efficacy in GVHD

Blazar, B. R. (PI), Griffin, T. J. (CoI), Hippen, K. L. (CoI) & Osborn, M. J. (CoI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

5/15/22 → 3/31/26

Project: Research project

Telemedicine-Delivered Time Restricted Eating As a Viable Alternative to Caloric Restriction for Treating Obesity in a Population with Type 2 (T2DM) diabetes

Chow, L. S. (PI), Harnack, L. J. (CoI), Helgeson, E. S. (CoI) & Mashek, D. (CoI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

4/1/22 → 3/31/26

Project: Research project

Recurrent tumor-specific transcripts as a source of neoantigens for NF1-associated malignant peripheral nerve sheath tumor immunoprevention

Largaespada, D. A. (PI), Griffin, T. J. (CoI) & Moertel, C. L. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/1/21 → 8/31/25

Project: Research project

Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis

Bhargava, M. (PI), Dincer, H. E. (CoI), Drake, J. M. (CoI), Griffin, T. J. (CoI) & Lock, E. (CoI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

8/15/21 → 7/31/25

Project: Research project

Cytoskeletal Interactions of Dystrophin

Ervasti, J. M. (PI), Lowe, D. A. (CoI) & Salapaka, M. V. (CoI)

NIH NIAMS NATL INST OF ARTHRIT

8/1/21 → 7/31/26

Project: Research project

Costamere Defects in Muscular Dystrophies

Ervasti, J. M. (PI) & Lowe, D. A. (CoI)

NIH NIAMS NATL INST OF ARTHRIT

3/1/21 → 2/28/26

Project: Research project

MUFA-SIRT1 signaling as a central node regulating healthspan

Mashek, D. (PI), Niedernhofer, L. J. (CoI) & Parker, L. L. (CoI)

NIH NAT'L INSTITUTE ON AGING (NIA)

9/15/20 → 5/31/25

Project: Research project

Mechanisms of immunoproteasome-mediated metabolic disorders

Kim, D.-H. (PI) & Chen, Y. (CoI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

5/1/20 → 4/30/25

Project: Research project

Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese Humans

Chow, L. S. (PI), Bolan, P. J. (CoI), Mashek, D. (CoI) & Ryder, J. R. (CoI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

4/1/20 → 12/31/25

Project: Research project

Finished

Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis (MoChaS)

Griffin, T. J. (PI), Drake, J. M. (CoI), Lock, E. (CoI), Hoff, I. N. (Other Role), Jagtap, P. D. (Other Role), Mehta, S. P. (Other Role) & Viken, K. J. (Other Role)

THE OHIO STATE UNIVERSITY, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

12/2/24 → 3/2/25

Project: Research project

Predictive Models of Beryllium Sensitization and Chronic Beryllium Disease

Bhargava, M. (PI), Griffin, T. J. (CoI), Hoff, I. N. (Other Role), Jagtap, P. D. (Other Role) & Noren, B. E. (Other Role)

NATIONAL JEWISH HEALTH, NATIONAL INSTITUTES OF HEALTH (NIH)

9/10/23 → 8/31/24

Project: Research project

Molecular Characterization of Progressive Pulmonary Sarcoidosis

Bhargava, M. (PI) & Griffin, T. J. (CoI)

NATIONAL JEWISH HEALTH, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/23 → 8/30/24

Project: Research project

Towards an integrated microbiome-host protein biomarker panel for early detection of ovarian cancer in routinely collected clinical samples

Griffin, T. J. (PI)

MN OVARIAN CANCER ALLIANCE

9/1/22 → 2/29/24

Project: Research project

Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging

Najt, C. P. (PI)

NIH NAT'L INSTITUTE ON AGING (NIA)

3/15/21 → 1/31/24

Project: Research project

Mechanisms of mTORC1 signaling to protein degradation pathways

Kim, D.-H. (PI)

NIH NIGMS NATL INST OF GENERAL

3/1/21 → 2/28/22

Project: Research project

Quantitative Proteomics of Intracellular Traffic in Down Syndrome Brain

Fatemi, S. H. (PI) & Griffin, T. J. (CoI)

JEROME LEJEUNE FOUNDATION USA

2/22/21 → 2/21/24

Project: Research project

Role of intestinal dendritic mTORC1 in T cell homeostasis and obesity: A Sponsored Research Agreementwith GI Cell.

Kim, D.-H. (PI)

GI-CELL INC

2/1/21 → 1/31/22

Project: Research project

Quantitative Subcellular Proteomics in Children and Adults with Idiopathic Autism

Fatemi, S. H. (PI) & Griffin, T. J. (CoI)

AUTISM RESEARCH INSTITUTE

1/1/21 → 12/31/23

Project: Research project

Cytoskeletal Interactions of Dystrophin

Ervasti, J. M. (PI), Lowe, D. A. (CoI) & Salapaka, M. V. (CoI)

NIH NIAMS NATL INST OF ARTHRIT

9/18/20 → 7/31/21

Project: Research project

Glycophagy in liver and skeletal muscle insulin sensitivity and energy metabolism

Heden, T. (PI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

8/1/20 → 8/31/22

Project: Research project

A transformative next-generation Orbitrap Tribrid system for the UMN and Upper Midwest

Griffin, T. J. (PI)

NIH Office of the Director

7/1/20 → 6/30/21

Project: Research project

Bioinformatics Analysis of Functions Expressed by Microbiomes

Jagtap, P. D. (PI)

AMERICAN SOCIETY FOR MICROBIOLOGY

3/1/20 → 12/1/21

Project: Research project

Endogenous Non-Substrate Modulation of SIRT1 Targeting

Najt, C. P. (PI)

AMERICAN HEART ASSOCIATION, INC

1/1/20 → 3/14/21

Project: Research project

Mechanism study on cellular metabolic homeostasis in healthy aging

Kim, D.-H. (PI)

KOREA FOOD RESEARCH INSTITUTE

1/1/20 → 12/31/20

Project: Research project

Role of intestinal dendritic mTORC1 in T cell homeostasis and obesity: A Sponsored Research Agreementwith GI Cell.

Kim, D.-H. (PI)

GI-CELL INC

10/1/19 → 9/30/20

Project: Research project

Slowing aging by multiplexing (SLAM)

Niedernhofer, L. J. (PI)

UNIVERSITY OF WASHINGTON, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/19 → 8/31/20

Project: Research project

Mechanical Characterization of Dystrophin

Ervasti, J. M. (PI)

MUSCULAR DYSTROPHY ASSOCIATION

8/1/19 → 7/31/22

Project: Research project

Role of the immunoproteasome in TSC pathogenesis and therapeutics

Kim, D.-H. (PI)

U.S. DEPARTMENT OF DEFENSE

4/15/19 → 10/14/22

Project: Research project

Mechanisms of mTORC1 signaling to protein degradation pathways

Kim, D.-H. (PI)

NIH NIGMS NATL INST OF GENERAL

3/8/19 → 8/14/24

Project: Research project

Role of glycophagy in exercise induced improvements in skeletal muscle insulin sensitivity

Heden, T. (PI)

AMERICAN HEART ASSOCIATION, INC

2/1/19 → 7/31/20

Project: Research project

Cancer Center Support Grant

Yee, D. (PI), AbuSalah, A. M. (CoI), Basu, S. (CoI), Beckman, K. B. (CoI), Bielinsky, A. K. (CoI), Cooley, S. A. (CoI), De For, T. E. (CoI), Falconer, S. N. (CoI), Felices, M. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Hatsukami, D. K. (CoI), Hendrickson, E. A. (CoI), Hirsch, B. A. (CoI), Joseph, A. M. (CoI), Kirstein, M. N. (CoI), Konety, B. R. (CoI), Koopmeiners, J. (CoI), Kuntz, K. M. (CoI), Lange, C. A. (CoI), Largaespada, D. A. (CoI), Le, C. T. (CoI), LeBeau, A. (CoI), Lindgren, B. R. (CoI), Luo, X. (CoI), Mc Carthy, J. B. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Nelson, H. H. (CoI), O'Sullivan, G. (CoI), Ondrey, F. G. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Peterson, B. A. (CoI), Sarver, A. L. (CoI), Shimizu, Y. (CoI), Siegfried, J. M. (CoI), Temiz, N. A. (CoI), Turesky, R. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Weigel, B. J. (CoI), Weisdorf, D. J. (CoI), Woo, J. (CoI) & Yamamoto, M. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Role of hepatic immunoproteasome in NAFLD and insulin resistance

Kim, D.-H. (PI)

AMERICAN DIABETES ASSOCIATION

1/1/19 → 12/31/21

Project: Research project

Molecular mechanisms of ATGL-regulated increases in oxidative metabolism

Mashek, D. (PI)

ELI LILLY AND COMPANY

11/15/18 → 11/15/21

Project: Research project

Dystrophin domains required for microtubule lattice orga

Nelson, D. M. (PI)

NIH NIAMS NATL INST OF ARTHRIT

6/13/18 → 9/11/20

Project: Research project

Mechanism of Aging Regulation by Nutrient-Sensing Pathways

Kim, D.-H. (PI)

KOREA FOOD RESEARCH INSTITUTE

6/1/18 → 12/31/19

Project: Research project

Lipid Binding Proteins in Obesity and Diabetes Syndromes

Bernlohr, D. A. (PI) & Mashek, D. (CoI)

NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

6/1/18 → 5/31/22

Project: Research project

The microbiota of the pediatric CF airway: what role does it play?

Hunter, R. C. (PI), Griffin, T. J. (CoI) & Wendt, C. H. (CoI)

ANN & ROBERT H LURIE CHILDREN'S HOSPITAL, NATIONAL INSTITUTES OF HEALTH (NIH)

5/1/18 → 4/30/22

Project: Research project

Metabolic and Systems Biology (TMED)

Projects

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