Medicine - Hematology, Oncology, Transplant - Projects and Grants

Finished

NRG-GU012: Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI)

Okazaki, I. (PI)

NRG ONCOLOGY FOUNDATION, INC., NIH NATIONAL CANCER INSTITUTE (NCI)

3/20/25 → 6/18/25

Project: Research project

A Phase II Clinical Trial of Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce Recurrence

Fujioka, N. (PI)

UNIVERSITY OF ARKANSAS

12/17/24 → 5/31/25

Project: Research project

A Phase 1 and 2a open-label trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity of LAVA-1207, a PSMA targeting bispecific gamma...

Zorko, N. A. (PI)

LAVA THERAPEUTICS

10/28/24 → 7/2/25

Project: Research project

A Phase III open-label, single-arm, multi-center study to assess the safety and efficacy of brigimadlin (BI907828) treatment in patients with treatment-na??ve or pre-treated advanced dedifferentiated liposarcoma

Skubitz, K. (PI)

BOEHRINGER INGELHEIM VETMEDICA, INC.

8/21/24 → 11/26/24

Project: Research project

Role of Factor XII in thrombo-inflammatory complications of sickle cell disease

Belcher, J. D. (PI)

THE UNIV OF N CAROLINA AT CHAPEL HILL, NATIONAL INSTITUTES OF HEALTH (NIH)

7/15/24 → 6/30/25

Project: Research project

A Phase 2, Open-label Study Evaluating Dosimetry, Randomized Dose Optimization, Dose Escalation and Efficacy of Ac-225 Rosopatamab Tetraxetan in Participants with PSMA PET-Positive Castration-Resistant Prostate Cancer

Antonarakis, E. (PI)

CONVERGENT THERAPEUTICS

7/3/24 → 7/2/25

Project: Research project

Augmenting CAR Regulatory T-cell Therapy for GVHD and Lymphoid Malignancies

Mcdonald-Hyman, C. S. (PI)

AMERICAN SOCIETY OF HEMATOLOGY

7/1/24 → 6/30/25

Project: Research project

A first-in-human, Phase 1/2, open-label, multi-center, dose-escalation, dose-optimization, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of PARP1 selective inhibitor, IMP1734

Beckwith, H. C. (PI)

EIKON THERAPEUTICS, INC

6/10/24 → 6/9/25

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

Juckett, M. B. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/24 → 3/31/25

Project: Research project

Inflammatory caspase activation in sickle cell disease

Belcher, J. D. (PI) & Vercellotti, G. M. (Co-Principal Investigator)

BAYLOR COLLEGE OF MEDICINE, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/24 → 3/31/25

Project: Research project

Study 1: PK/PD and target engagement analysis

Belcher, J. D. (PI)

CELLARITY, INC

4/1/24 → 1/14/25

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

Juckett, M. B. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/24 → 3/31/25

Project: Research project

Caregiver Support Development

Blaes, A. H. (PI)

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

3/4/24 → 6/29/24

Project: Research project

Phase 2 Trial of Neoadjuvant KRAS G12C directed therapy with Adagrasib (MRTX849) with or without Nivolumab in Resectable Non-Small Cell Lung Cancer (Neo-KAN)

Manning, B. M. (PI)

JOHNS HOPKINS UNIVERSITY, MIRATI THERAPEUTICS, INC.

2/1/24 → 6/30/25

Project: Research project

Liver Tissue Distribution System (LTDS)

Davis, Z. B. (PI)

NATIONAL INSTITUTES OF HEALTH (NIH)

11/29/23 → 11/28/24

Project: Research project

Cancer Center Survivorship Research Forum

Blaes, A. H. (PI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/18/23 → 8/31/24

Project: Research project

Augmenting CAR Regulatory T-cell Therapy for GVHD and Lymphoid Malignancies

Mcdonald-Hyman, C. S. (PI)

AMERICAN SOCIETY OF HEMATOLOGY

7/1/23 → 6/30/24

Project: Research project

Targeting TP53 mutant AML stem cells by suppressing NFkB

Sachs, Z. (PI)

AMERICAN SOCIETY OF HEMATOLOGY

7/1/23 → 6/30/25

Project: Research project

Porphyrias Consortium

Mazepa, M. (PI)

MOUNT SINAI SCHOOL OF MEDICINE, NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/23 → 6/30/24

Project: Research project

Bruton Tyrosine Kinase Inhibitors in Sickle Cell Disease

Belcher, J. D. (PI) & Vercellotti, G. M. (CoI)

SANOFI-AVENTIS US

6/5/23 → 6/5/25

Project: Research project

Efficacy of a Pill-Dispensing System to Increase Disposal of Unused Opioids and Reduce Refill Rates after Cancer Surgery

Cogan, J. (PI)

COLUMBIA UNIVERSITY, NIH NIDA NATL INST ON DRUG AB

5/15/23 → 3/31/25

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

El Jurdi, N. (PI)

FRED HUTCHINSON CANCER CENTER, NIH NATIONAL CANCER INSTITUTE (NCI)

4/1/23 → 3/31/25

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

El Jurdi, N. (PI)

FRED HUTCHINSON CANCER CENTER, NIH NATIONAL CANCER INSTITUTE (NCI)

4/1/23 → 3/31/25

Project: Research project

Targeting CD83 to reduce leukemia relapse and GVHD after allogeneic hematopoietic cell transplantation

Betts, B. (PI), Holtan, S. G. (CoI) & Linden, M. A. (CoI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

4/1/23 → 8/31/23

Project: Research project

Treatment of Stage I-III Squamous Cell Carcinoma (SCC) of the Anal Canal

Butler, M. E. (PI), Arsoniadis, E. G. (CoI), Church, T. R. (CoI), Ester, E. C. (CoI), Goffredo, P. (CoI), Greeno, E. W. (CoI), Lamina, T. (CoI), Southwell, B. J. (CoI), Sultan, S. (CoI) & Wilt, T. J. (CoI)

U.S. DEPT OF HEALTH & HUMAN SERV AHRQ

3/27/23 → 4/16/24

Project: Research project

A Phase 1/2, First-In-Human, Multi-Part, Open-Label Study to Investigate the Safety, Tolerability,Pharmacokinetics, Biological and Clinical Activity of DF9001 as a monotherapy and in combination withnivolumab in Patients With Advanced (Unresectable, Re

Beckwith, H. C. (PI)

DRAGONFLY THERAPEUTICS, INC

1/24/23 → 6/30/24

Project: Research project

A Phase 2b study of TAK-755 (rADAMTS13) with minimal to no PEX in the treatment of patients with iTTP

Vercellotti, G. M. (PI)

TAKEDA DEVELOPMENT CENTER AMERICAS, INC.

1/5/23 → 6/30/25

Project: Research project

Porphyrias Consortium

Mazepa, M. (PI)

MOUNT SINAI SCHOOL OF MEDICINE, NATIONAL INSTITUTES OF HEALTH (NIH)

1/1/23 → 6/30/23

Project: Research project

Complement and Pain in Sickle Cell Disease

Belcher, J. D. (PI) & Vercellotti, G. M. (CoI)

Omeros Corporation

1/1/23 → 12/31/24

Project: Research project

GTB 3650 ( new Trikes)

Juckett, M. B. (PI)

GT BIOPHARMA, INC

11/1/22 → 2/29/24

Project: Research project

Liver Tissue Distribution System (LTDS)

Davis, Z. B. (PI) & Grzywacz, B. J. (Prior Principal Investigator)

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

9/29/22 → 5/28/24

Project: Research project

A Phase I, Open-Label, Multicenter Study of FT536as Monotherapy and in Combination with MonoclonalAntibodies in Subjects with Advanced Solid Tumors

Patel, M. R. (PI)

FATE THERAPEUTICS, INC.

9/22/22 → 6/5/23

Project: Research project

Reparative Treg and Microparticle Therapy for the Prevention of VCA Acute and Chronic Rejection

Betts, B. (PI)

UNIVERSITY OF PITTSBURGH, U.S. DEPARTMENT OF DEFENSE

9/15/22 → 9/14/23

Project: Research project

Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell Disease

Belcher, J. D. (PI) & Vercellotti, G. M. (CoI)

HILLHURST BIOPHARMACEUTICALS, INC, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/22 → 8/31/24

Project: Research project

A Randomized Phase II Study Comparing Sequential High dose Testosterone andEnzalutamide to Enzalutamide alone in Asymptomatic Men with Castration ResistantMetastatic Prostate Cancer

Antonarakis, E. (PI)

JOHNS HOPKINS UNIVERSITY, US DEPT OF DEFENSE ARMY

9/1/22 → 3/31/25

Project: Research project

Efficacy of a Password-Protected, Pill-Dispensing Device to Reduce Opioid Refills After Cancer-RelatedSurgery

Cogan, J. (PI)

CONQUER CANCER FOUNDATION

8/1/22 → 1/31/24

Project: Research project

Estrogen-driven breast tumorigenesis in invasive lobular carcinoma

Ostrander, J. H. (PI), Eaton, A. (CoI) & Nelson, A. C. (CoI)

U.S. DEPARTMENT OF DEFENSE

7/15/22 → 7/14/25

Project: Research project

A Phase 3 Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of AB-205 plus Standard of Care versus Placebo plus Standard of Care in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell

O'Leary, D. H. (PI)

ANGIOCRINE BIOSCIENCE, INC.

7/12/22 → 11/18/24

Project: Research project

Targeting channels of ovarian tumor cell communication

Lou, E. (PI)

MN OVARIAN CANCER ALLIANCE

7/1/22 → 6/30/23

Project: Research project

ADAR1 regulation of viro-immunotherapy in malignant pleural mesothelioma

Kratzke, R. A. (PI) & Patel, M. R. (CoI)

U.S. DEPARTMENT OF DEFENSE

7/1/22 → 12/31/23

Project: Research project

Hematology-Focused Fellowship Training Program

Datta, Y. H. (PI) & Boucher, A. (CoI)

AMERICAN SOCIETY OF HEMATOLOGY

7/1/22 → 6/30/24

Project: Research project

PoC studies for Placenta Growth Factor Inhibition as a therapeutic approach in SCD

Belcher, J. D. (PI) & Vercellotti, G. M. (CoI)

CSL BEHRING GMBH

6/27/22 → 12/30/23

Project: Research project

App-Assisted Day Reconstruction to Reduce Treatment Burden and Logistic Toxicity in Cancer Patients

Vogel, R. (PI) & Blaes, A. H. (CoI)

DAYNAMICA, INC., NATIONAL INSTITUTES OF HEALTH (NIH)

6/15/22 → 6/15/24

Project: Research project

Development of a novel personalized medicine platform using apheretically isolated circulating tumor cells to assess drug responsiveness in prostate cancer

Drake, J. M. (PI) & Hwang, J. (CoI)

ASTRIN BIOSCIENCES, INC, NATIONAL INSTITUTES OF HEALTH (NIH)

6/1/22 → 5/31/23

Project: Research project

A PHASE II STUDY EVALUATING THE SAFETY AND EFFICACY OF GLOFITAMAB IN COMBINATION WITHRITUXIMAB (R) PLUS CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE, AND PREDNISONE CHOP) INCIRCULATING TUMOR (ct)DNA HIGH-RISK PATIENTS WITH UNTREATED DIFFUSE LARGE B-CELL

Desai, S. (PI)

HOFFMANN-LA ROCHE PHARMACEUTICALS

5/17/22 → 3/31/24

Project: Research project

RID HIV: Reversing Immune Dysfunction for HIV Eradication

Miller, J. S. (PI)

SCRIPPS RESEARCH INSTITUTE DBA CALIBR, NIH Nat'l Inst of Allergy & Infect Dis

5/1/22 → 4/30/25

Project: Research project

Integrating Health Informatics in A Scalable Stepped Care Self-Management Program for Survivors afterHematopoietic Cell Transplantation (INSPIRE)

Holtan, S. G. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/22 → 11/30/23

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

El Jurdi, N. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/22 → 3/31/23

Project: Research project

Novel intervention approaches to alleviate allogeneic transplant-related morbidity and mortality

El Jurdi, N. (PI) & Weisdorf, D. J. (Prior Principal Investigator)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/22 → 1/31/24

Project: Research project

Predicting Quality of Response to Specific Treatments (PQRST)

El Jurdi, N. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

4/1/22 → 3/31/23

Project: Research project

Medicine - Hematology, Oncology, Transplant

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