Medicinal Chemistry

Active

Development of Selective, Allosteric Inhibitors of Cyclin-Dependent Kinase 2 for theTherapeutic Treatment of Cancer

Holdaway, K.

AMERICAN FDN FOR PHARMACEUTICAL EDUC

9/1/23 → 8/31/24

Project: Research project

Discovery and development of allosteric inhibitors of Cdk2/cyclin E as non-toxic ovarian cancer drugs

Georg, G. & Wong, H. L.

MN OVARIAN CANCER ALLIANCE

7/1/23 → 6/30/24

Project: Research project

Species specific optimization and development of rifamycins for the treatment of nontuberculous mycobacterial lung disease

Aldrich, C.

HACKENSACK MERIDIAN HEALTH, INC, NATIONAL INSTITUTES OF HEALTH (NIH)

6/6/23 → 5/31/24

Project: Research project

Enhance myogenic transdifferentiation efficiency using engineering approaches

Shen, W. & Hawkinson, J.

NIH NIAMS NATL INST OF ARTHRIT

5/1/23 → 4/30/25

Project: Research project

Design and Synthesis of TLR7, TLR8, and NLRP3 Immunostimulatory Agents

Ferguson, D. M.

SEAGEN INC

1/17/23 → 1/31/24

Project: Research project

The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute Myelogenous Leukemia

Tretyakova, N. Y.

CASE WESTERN RESERVE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)

12/1/22 → 11/30/23

Project: Research project

Chemical Synthesis Facility

Gurvich, V. J. & Georg, G.

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

9/29/22 → 9/28/23

Project: Research project

Synthetic Chemistry Support for the TDB Medicinal Chemistry Team

Gurvich, V. J. & Georg, G.

NIH NIDA NATL INST ON DRUG AB

9/28/22 → 9/27/24

Project: Research project

Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking

Hecht, S. S., Fujioka, N., Hatsukami, D. K., Henzler, C., Murphy, S. E., Stepanov, I. & Tretyakova, N. Y.

NIH NATIONAL CANCER INSTITUTE (NCI)

9/16/22 → 8/31/27

Project: Research project

A Novel Small Molecule for The Prevention and Treatment of Diabetic Retinopathy

Duerfeldt, A. S.

EXCITANT THERAPEUTICS LLC, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/22 → 6/30/24

Project: Research project

NCI P01 Project 3

Aihara, H. & Harki, D. A.

UT HEALTH SCIENCE CENTER SAN ANTONIO, NATIONAL INSTITUTES OF HEALTH (NIH)

8/1/22 → 7/31/24

Project: Research project

Midwest AViDD Center

Harris, R., Aihara, H., Aliota, M. T., Harki, D. A., Langlois, R. A., Li, F., Liang, Y. & Ly, H.

NIH Nat'l Inst of Allergy & Infect Dis

5/16/22 → 4/30/25

Project: Research project

RET Regulation and Targeting in Neuroendocrine Prostate Cancer

Drake, J. M., Dehm, S. M., Eaton, A., Harki, D. A. & Hwang, J.

NIH NATIONAL CANCER INSTITUTE (NCI)

5/1/22 → 4/30/27

Project: Research project

Development/Validation of Rete Testis Microcannulation for the Assessment of Novel Chemical Scaffolds That Penetrate the Blood Testis Barrier

Wong, H. L. & Georg, G.

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

9/17/21 → 9/16/26

Project: Research project

Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding

Birnbaum, A., Huang, R. S. S. & Remmel, R. P.

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

8/4/21 → 5/31/27

Project: Research project

Anchimerically Activatable Anti-Zika/Dengue ProTides

Wagner, C. R.

NIH Nat'l Inst of Allergy & Infect Dis

8/1/21 → 7/31/26

Project: Research project

Targeting N-Myc with Selective Aurora Kinase A Degraders for Neuroblastoma Therapy

Harki, D. A., Harris, R. & Levinson, N. M.

U.S. DEPARTMENT OF DEFENSE

7/15/21 → 7/14/24

Project: Research project

A novel TNFR1-selective small molecule inhibitor to treat rheumatoid arthritis and related inflammatory diseases

Binstadt, B. A., Sachs, J. N. & Ferguson, D. M.

RHEUMATOLOGY RESEARCH FOUNDATION

7/1/21 → 6/30/24

Project: Research project

Melanocortin Receptor Selective Ligands

Haskell-Luevano, C.

NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/21 → 4/30/25

Project: Research project

TLR7/8 agonist design and delivery for effective anticancer immune response

Ferguson, D. M. & Griffith, T. S.

TEMPLE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)

6/8/21 → 5/31/26

Project: Research project

Mycotoxin production by the soybean red leaf blotch fungus Coniothyrium glycines

Shier, T.

USDA AGRICULTURAL RESEARCH SERVICE

4/7/21 → 4/30/24

Project: Research project

Small Molecule PPAR-alpha Agonism as a Novel Approach to Treat Eye Vascular Diseases

Duerfeldt, A. S.

NIH NEI NATL EYE INST

3/1/21 → 4/30/25

Project: Research project

Chemical Methods to Characterize Penicillin-Binding Protein Function and Interactions

Carlson, E. E. & Ambrose, E. A.

NIH NIGMS NATL INST OF GENERAL

9/18/20 → 6/30/24

Project: Research project

Targeting Na,K-ATPase alpha4 for male contraception

Georg, G. & Wong, H. L.

UNIVERSITY OF KANSAS MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

8/15/20 → 4/30/25

Project: Research project

Kidney DNA Adductomics

Turesky, R., Guo, J., Maertens, L. A., Villalta, P. W., Walmsley, S. J. & Weight, C. J.

NIH NATL INST OF ENVIRON HEALTH SCIENCES

8/7/20 → 5/31/25

Project: Research project

Chemical biology of Peptide Regulation of Opioid Receptor Function

Haskell-Luevano, C. & Portoghese, P. S.

NIH NIDA NATL INST ON DRUG AB

5/1/20 → 2/28/25

Project: Research project

Structural Dynamics of Muscle Calcium ATPase Regulation

Thomas, D. D., Aihara, H., Cornea, R. L. & Aldrich, C.

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

5/1/20 → 4/30/24

Project: Research project

Membrane-active quinoline and quinazoline antibacterials that target Gram positive pathogens

Aldrich, C.

DARTMOUTH COLLEGE, NATIONAL INSTITUTES OF HEALTH (NIH)

3/1/20 → 2/28/24

Project: Research project

Targeting Effector Immune cells to Cancer with Chemically Self-Assembled Nanorings (CSANs)

Wagner, C. R. & De For, T. E.

NIH NATIONAL CANCER INSTITUTE (NCI)

3/1/20 → 2/28/25

Project: Research project

Time-resolved FRET-based allostery sensors for any protein kinase drug target

Levinson, N. M., Drake, J. M., Georg, G. & Thomas, D. D.

NIH NATIONAL CANCER INSTITUTE (NCI)

3/1/20 → 2/29/24

Project: Research project

MASTER: CRO Support for NCATS Medicinal Chemistry for Lead Optimization

Gurvich, V. J., Georg, G., Hawkinson, J., Walters, M. A. & Wong, H. L.

NIH NIDA NATL INST ON DRUG AB

9/26/19 → 9/25/26

Project: Research project

DNA Protein Cross-Links:Cellular Effects and Repair Mechanisms

Tretyakova, N. Y., Campbell, C. R. & Moriarity, B. S.

NIH NATL INST OF ENVIRON HEALTH SCIENCES

9/10/19 → 5/31/24

Project: Research project

Minnesota HHEAR Targeted Analysis Laboratory

Peterson, L. A., Balbo, S., Gross, M. D., Hecht, S. S., Murphy, S. E., Stepanov, I., Turesky, R. & Villalta, P. W.

NIH NATL INST OF ENVIRON HEALTH SCIENCES

9/5/19 → 3/31/25

Project: Research project

DNA adductome of human bladder from the tobacco exposome

Turesky, R., Bellamri, M. & Yun, B.

NIH NATL INST OF ENVIRON HEALTH SCIENCES

4/1/19 → 12/31/23

Project: Research project

Caspase-2 Probe Compounds

Ashe, K. H., Finzel, B. C. & Nelson, K.

NIH NAT'L INSTITUTE ON AGING (NIA)

2/15/19 → 11/30/23

Project: Research project

Cancer Center Support Grant

Yee, D., AbuSalah, A. M., Basu, S., Beckman, K. B., Bielinsky, A. K., Cooley, S. A., De For, T. E., Falconer, S. N., Felices, M., Griffin, T. J., Hallstrom, T. C., Hatsukami, D. K., Hendrickson, E. A., Hirsch, B. A., Joseph, A. M., Kirstein, M. N., Konety, B. R., Koopmeiners, J., Kuntz, K. M., Lange, C. A., Largaespada, D. A., Le, C. T., LeBeau, A., Lindgren, B. R., Luo, X., Mc Carthy, J. B., McKenna, D. H., Miller, J. S., Moriarity, B. S., Nelson, H. H., O'Sullivan, G., Ondrey, F. G., Pennell, C. A., Petersen, A. J., Peterson, L. A., Peterson, B. A., Sarver, A. L., Shimizu, Y., Siegfried, J. M., Temiz, N. A., Turesky, R., Vogel, R., Wagner, J. E., Wang, J., Weigel, B. J., Weisdorf, D. J., Woo, J. & Yamamoto, M.

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage

Tretyakova, N. Y.

TEXAS A & M UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)

2/1/19 → 1/31/24

Project: Research project

Gut Microbiota and Effect on Immune Suppressants in Transplantation

Jacobson, P. A., Matas, A. J. & Remmel, R. P.

HENNEPIN HEALTHCARE RESEARCH INSTITUTE, NATIONAL INSTITUTES OF HEALTH (NIH)

2/1/19 → 1/31/24

Project: Research project

Targeting Biotin Metabolism in Mycobacterium Tuberculosis

Aldrich, C. & Ferguson, D. M.

NIH Nat'l Inst of Allergy & Infect Dis

1/15/19 → 12/30/23

Project: Research project

Smoking-Induced Epigenetic Changes in the Lung: Role of

Tretyakova, N. Y., Liu, S., Nelson, H. H. & Guan, W.

NIH NATIONAL CANCER INSTITUTE (NCI)

10/1/17 → 12/31/23

Project: Research project

DNA adductomics of the urinary system

Turesky, R.

NIH NATIONAL CANCER INSTITUTE (NCI)

6/20/17 → 6/30/24

Project: Research project

Medicinal Chemistry

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