Medicinal Chemistry

UNIVERSITY OF CALIFORNIA, DAVIS, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

2/15/25 → 1/31/27

Project: Research project

Synthesis of potential contraceptive agents

Georg, G. (PI) & Cheryala, N. (Other Role)

POPULATION COUNCIL INC

2/1/25 → 4/30/25

Project: Research project

Calmodulin and regulation of Cardiac Ryanodine Receptor and CaMKII

Rebbeck, R. T. (PI), Aldrich, C. (CoI), Svensson, B. (CoI), Thomas, D. D. (CoI), Solberg, J. C. (Other Role) & Yuen, S. L. (Other Role)

1/1/25 → 11/30/25

Project: Research project

Triptonide Prodrugs

Georg, G. (PI), Wong, H. L. (CoI), Jakkaraj, S. R. (Other Role), John, K. E. (Other Role) & Vantaddu, N. R. (Other Role)

AMERICAN CHEMICAL SOCIETY

12/15/24 → 5/31/25

Project: Research project

Novel Protein Degraders for Treating RET Positive Cancer

Drake, J. M. (PI), Harki, D. A. (CoI), Kabir, F. (Graduate Student) & Tengse, S. B. (Graduate Student)

LUNGevity

11/1/24 → 10/31/26

Project: Research project

Next Generation Aurora Kinase A/N-Myc Degraders for Neuroblastoma Therapy

Hirsch, L. E. (PI)

9/1/24 → 8/31/25

Project: Research project

Targeting drug-resistant breast cancers with allosteric cyclin-dependent kinase 2 inhibitors

Georg, G. (PI) & Holdaway, K. (Graduate Student)

MAYO CLINIC ROCHESTER, NIH NATIONAL CANCER INSTITUTE (NCI)

9/1/24 → 8/31/25

Project: Research project

Bifunctional Inhibitors of STING as Chemical Probes for Diabetic Retinopathy

Duerfeldt, A. S. (PI)

NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/24 → 8/31/26

Project: Research project

Discovery and Development of RARalpha and RARgamma Antagonists as Male Birth Control Agents

Haque, E. (PI)

8/26/24 → 8/25/26

Project: Research project

Development of Selective TSSK Degraders and Inhibitors for Non-Hormonal Male Contraception

Holdaway, J. A. (PI)

NATIONAL INSTITUTES OF HEALTH (NIH)

8/26/24 → 8/25/26

Project: Research project

DEL screening campaign for contraceptive and cancer targets

Georg, G. (PI)

8/1/24 → 7/31/26

Project: Research project

Protein structural biophysics driving drug discovery for cardiac calcium transport regulation, producing translational advances and mechanistic insights

Thomas, D. D. (PI), Aldrich, C. (CoI) & Rebbeck, R. T. (CoI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

5/1/24 → 4/30/29

Project: Research project

Catsper inhibitors for male contraception

Georg, G. (PI) & Wong, H. L. (CoI)

2/1/24 → 1/31/26

Project: Research project

Cancer Center Support Grant

Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)

2/1/24 → 1/31/29

Project: Research project

Testis-Specific Serine Kinases 1-3 (TSSKs1-3) as targets for non-hormonal male contraception

Georg, G. (PI)

1/24/24 → 1/23/26

Project: Research project

Development/Validation of Rete Testis Microcannulation for the Assessment of Novel Chemical Scaffolds That Penetrate the Blood Testis Barrier

Wong, H. L. (PI) & Georg, G. (CoI)

PURDUE UNIVERSITY, NIH NATL INST OF ENVIRON HEALTH SCIENCES

9/19/23 → 8/31/26

Project: Research project

Mechanisms of PhIP-induced dopaminergic neurotoxicity

Turesky, R. (PI) & Bellamri, M. (CoI)

9/15/23 → 8/31/26

Project: Research project

Development of Selective, Allosteric Inhibitors of Cyclin-Dependent Kinase 2 for theTherapeutic Treatment of Cancer

Holdaway, K. (PI)

AMERICAN FDN FOR PHARMACEUTICAL EDUC

9/1/23 → 8/31/25

Project: Research project

Microbial Synthesis of Therapeutic Bile Acids for Alzheimer's Disease

Smanski, M. J. (PI), Georg, G. (CoI) & Liao, D. (CoI)

METSELEX, INC., NATIONAL INSTITUTES OF HEALTH (NIH)

8/21/23 → 7/31/25

Project: Research project

Development of a novel broad spectrum antifungal therapeutic targeting Glycosylphosphatidylinositol (GPI) biosynthesis and cell wall biogenesis

Aldrich, C. (PI)

PROKARYOTICS INC, NATIONAL INSTITUTES OF HEALTH (NIH)

8/15/23 → 7/31/25

Project: Research project

T cell Epitope Discovery in Sarcoidosis

Pinilla, C. (PI) & Giulianotti, M. A. (CoI)

UNIVERSITY OF COLORADO, NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/23 → 6/30/25

Project: Research project

Discovery and development of OGG1 activators as precision drugs for modification of Alzheimer?s disease progression

Gurvich, V. J. (PI) & Georg, G. (CoI)

LUCIOLE PHARMACEUTICALS, INC., NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/23 → 8/31/25

Project: Research project

Species specific optimization and development of rifamycins for the treatment of nontuberculous mycobacterial lung disease

Aldrich, C. (PI)

HACKENSACK MERIDIAN HEALTH, INC, NATIONAL INSTITUTES OF HEALTH (NIH)

6/6/23 → 5/31/25

Project: Research project

Enhance myogenic transdifferentiation efficiency using engineering approaches

Shen, W. (PI) & Hawkinson, J. (CoI)

NIH NIAMS NATL INST OF ARTHRIT

5/1/23 → 4/30/25

Project: Research project

The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute Myelogenous Leukemia

Tretyakova, N. Y. (PI)

CASE WESTERN RESERVE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)

12/1/22 → 11/30/25

Project: Research project

Chemical Synthesis Facility

Gurvich, V. J. (PI) & Georg, G. (CoI)

9/29/22 → 9/28/25

Project: Research project

Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking

Hecht, S. S. (PI), Fujioka, N. (CoI), Hatsukami, D. K. (CoI), Henzler, C. (CoI), Murphy, S. E. (CoI), Stepanov, I. (CoI) & Tretyakova, N. Y. (CoI)

LEIDOS BIOMEDICAL RESEARCH, INC., NIH NATIONAL CANCER INSTITUTE (NCI)

9/16/22 → 8/31/27

Project: Research project

Chemical Biology Consortium

Georg, G. (PI)

8/31/22 → 8/30/25

Project: Research project

APOBEC Mutagenesis in Breast Cancer

Harki, D. A. (PI), Walters, M. A. (CoI) & Vogel, R. (Other Role)

UT HEALTH SCIENCE CENTER SAN ANTONIO, NATIONAL INSTITUTES OF HEALTH (NIH)

8/1/22 → 7/31/25

Project: Research project

Midwest AViDD Center

Harris, R. (PI), Aihara, H. (CoI), Aliota, M. T. (CoI), Harki, D. A. (CoI), Langlois, R. A. (CoI), Li, F. (CoI), Liang, Y. (CoI) & Ly, H. (CoI)

NIH Nat'l Inst of Allergy & Infect Dis

5/16/22 → 4/30/25

Project: Research project

RET Regulation and Targeting in Neuroendocrine Prostate Cancer

Drake, J. M. (PI), Dehm, S. M. (CoI), Eaton, A. (CoI), Harki, D. A. (CoI) & Hwang, J. (CoI)

5/1/22 → 4/30/27

Project: Research project

Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding

Birnbaum, A. (PI), Huang, R. S. S. (CoI) & Remmel, R. P. (CoI)

NIH Nat'l Inst of Allergy & Infect Dis

8/4/21 → 5/31/27

Project: Research project

Anchimerically Activatable Anti-Zika/Dengue ProTides

Wagner, C. R. (PI)

8/1/21 → 7/31/26

Project: Research project

Targeting N-Myc with Selective Aurora Kinase A Degraders for Neuroblastoma Therapy

Harki, D. A. (PI), Harris, R. (CoI) & Levinson, N. M. (CoI)

U.S. DEPARTMENT OF DEFENSE

7/15/21 → 7/14/25

Project: Research project

Melanocortin Receptor Selective Ligands

Haskell-Luevano, C. (PI)

NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/21 → 4/30/25

Project: Research project

TLR7/8 agonist design and delivery for effective anticancer immune response

Ferguson, D. M. (PI) & Griffith, T. S. (CoI)

TEMPLE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)

6/8/21 → 5/31/26

Project: Research project

Small Molecule PPAR-alpha Agonism as a Novel Approach to Treat Eye Vascular Diseases

Duerfeldt, A. S. (PI)

NIH NEI NATL EYE INST

3/1/21 → 4/30/25

Project: Research project

Targeting Na,K-ATPase alpha4 for male contraception

Georg, G. (PI) & Wong, H. L. (CoI)

UNIVERSITY OF KANSAS MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

8/15/20 → 4/30/25

Project: Research project

Kidney DNA Adductomics

Turesky, R. (PI), Guo, J. (CoI), Maertens, L. A. (CoI), Villalta, P. W. (CoI), Walmsley, S. J. (CoI) & Weight, C. J. (CoI)

NIH NATL INST OF ENVIRON HEALTH SCIENCES

8/7/20 → 5/31/25

Project: Research project

Chemical biology of Peptide Regulation of Opioid Receptor Function

Haskell-Luevano, C. (PI) & Portoghese, P. S. (Co-Principal Investigator)

NIH NIDA NATL INST ON DRUG AB

5/1/20 → 2/28/26

Project: Research project

Targeting Effector Immune cells to Cancer with Chemically Self-Assembled Nanorings (CSANs)

Wagner, C. R. (PI) & De For, T. E. (CoI)