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2020

A novel gene editing system to treat both Tay–Sachs and Sandhoff diseases

Ou, L., Przybilla, M. J., Tăbăran, A. F., Overn, P., O’Sullivan, M. G., Jiang, X., Sidhu, R., Kell, P. J., Ory, D. S. & Whitley, C. B., Jan 1 2020, (Accepted/In press) In : Gene therapy.

Research output: Contribution to journalArticle

1 Scopus citations

A novel terpenoid class for prevention and treatment of KRAS-driven cancers: Comprehensive analysis using in situ, in vitro, and in vivo model systems

Ganaie, A. A., Siddique, H. R., Sheikh, I. A., Parray, A., Wang, L., Panyam, J., Villalta, P. W., Deng, Y., Konety, B. R. & Saleem, M., Jan 1 2020, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

A perspective and framework for developing sample type specific databases for LC/MS-based clinical metabolomics

Reisdorph, N. A., Walmsley, S. & Reisdorph, R., Jan 2020, In : Metabolites. 10, 1, 8.

Research output: Contribution to journalArticle

Open Access

A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure

Meier, E., Lindgren, B. R., Anderson, A., Reisinger, S. A., Norton, K. J., Jensen, J., Strayer, L., Dick, L., Tang, M. K., Chen, M., Carmella, S. G., Hecht, S. S., Murphy, S. E., Yang, J., Stepanov, I., O'Connor, R. J., Shields, P. G. & Hatsukami, D. K., Apr 17 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 4, p. 473-481 9 p.

Research output: Contribution to journalArticle

CD200 checkpoint reversal: A novel approach to immunotherapy a C

Xiong, Z., Mesias, E. A., Elizabeth Pluhar, G., Rathe, S. K., Largaespada, D. A., Sham, Y. Y., Moertel, C. L. & Olin, M. R., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 232-241 10 p.

Research output: Contribution to journalArticle

Open Access

Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin

Ming, X., Michaelson-Richie, E. D., Groehler, A. S., Villalta, P. W., Campbell, C. & Tretyakova, N. Y., May 2020, In : DNA Repair. 89, 102840.

Research output: Contribution to journalArticle

Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors

Mo, C., Zhang, Z., Li, Y., Huang, M., Zou, J., Luo, J., Tu, Z-C., Xu, Y., Ren, X., Ding, K. & Lu, X., Jan 9 2020, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Development of a DNA Adductome Mass Spectral Database

Guo, J., Turesky, R. J., Tarifa, A., Decaprio, A. P., Cooke, M. S., Walmsley, S. J. & Villalta, P. W., Apr 20 2020, In : Chemical research in toxicology. 33, 4, p. 852-854 3 p.

Research output: Contribution to journalArticle

Diagnosis of canine renal lymphoma by cytology and flow cytometry of the urine

Witschen, P. M., Sharkey, L. C., Seelig, D. M., Granick, J. L., Dykstra, J. A., Carlson, T. W. & Motschenbacher, L. O., Mar 1 2020, In : Veterinary Clinical Pathology. 49, 1, p. 137-142 6 p.

Research output: Contribution to journalArticle

Diverse AR gene rearrangements mediate resistance to androgen receptor inhibitors in metastatic prostate cancer

Li, Y., Yang, R., Henzler, C. M., Ho, Y., Passow, C., Auch, B., Carreira, S., Rodrigues, D. N., Bertan, C., Hwang, T. H., Quigley, D. A., Dang, H. X., Morrissey, C., Fraser, M., Plymate, S. R., PlymateMaher, C. A., Feng, F. Y., De Bono, J. S. & Dehm, S. M., Apr 15 2020, In : Clinical Cancer Research. 26, 8, p. 1965-1976 12 p.

Research output: Contribution to journalArticle

Open Access

Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer

Glumac, P. M., Gallant, J. P., Shapovalova, M., Li, Y., Murugan, P., Gupta, S., Coleman, I. M., Nelson, P. S., Dehm, S. M. & Lebeau, A. M., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1054-1064

Research output: Contribution to journalArticle

Open Access

Field application of digital technologies for health assessment in the 10,000 families study

Thyagarajan, B., Nelson, H. H., Poynter, J. N., Prizment, A. E., Roesler, M. A., Cassidy, E., Putnam, S., Amos, L., Hickle, A., Reilly, C., Spector, L. G. & Lazovich, D., Jan 1 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 4, p. 744-751 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

Perez Kerkvliet, C., Dwyer, A. R., Diep, C. H., Oakley, R. H., Liddle, C., Cidlowski, J. A. & Lange, C. A., May 1 2020, In : Breast Cancer Research. 22, 1, 39.

Research output: Contribution to journalArticle

Open Access

Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard

Chen, H., Cui, Z., Hejazi, L., Yao, L., Walmsley, S. J., Rizzo, C. J. & Turesky, R. J., Apr 20 2020, In : Chemical research in toxicology. 33, 4, p. 988-998 11 p.

Research output: Contribution to journalArticle

Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function

Sarhan, D., Wang, J., Arvindam, U. S., Hallstrom, C., Verneris, M. R., Grzywacz, B., Warlick, E., Blazar, B. R. & Miller, J. S., Mar 12 2020, In : JCI Insight. 5, 5, e130155.

Research output: Contribution to journalArticle

Open Access

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Laoharawee, K., Osum, S. H., Larsson, A. T., Williams, K. B., Stratton, N., Yamamoto, K., Peterson, J. J., Rathe, S. K., Mills, L. J., Hudson, W. A., Crosby, M. R., Wang, M., Rahrmann, E. P., Moriarity, B. S. & Largaespada, D. A., Jul 2020, In : Bone. 136, 115353.

Research output: Contribution to journalArticle

Relationships between the nicotine metabolite ratio and a panel of exposure and effect biomarkers: Findings from two studies of U.S. commercial cigarette smokers

Carroll, D. M., Murphy, S. E., Benowitz, N. L., Strasser, A. A., Kotlyar, M., Hecht, S. S., Carmella, S. G., McClernon, F. J., Pacek, L. R., Dermody, S. S., Vandrey, R. G., Donny, E. C. & Hatsukami, D. K., Jan 1 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 4, p. 871-879 9 p.

Research output: Contribution to journalArticle

Open Access

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

Wang, Y., Narayanapillai, S. C., Tessier, K. M., Strayer, L. G., Upadhyaya, P., Hu, Q., Kingston, R., Salloum, R. G., Lu, J., Hecht, S. S., Hatsukami, D. K., Fujioka, N. & Xing, C., May 1 2020, In : Cancer prevention research (Philadelphia, Pa.). 13, 5, p. 483-492 10 p.

Research output: Contribution to journalArticle

2019
6 Scopus citations

A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma

Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Jan 1 2019, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journalArticle

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Bosnakovski, D., da Silva, M. T., Sunny, S. T., Ener, E. T., Toso, E. A., Yuan, C., Cui, Z., Walters, M. A., Jadhav, A. & Kyba, M., Sep 11 2019, In : Science advances. 5, 9, eaaw7781.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Bellamri, M., Yao, L., Bonala, R., Johnson, F., von Weymarn, L. B. & Turesky, R., Jul 1 2019, In : Archives of Toxicology. 93, 7, p. 1893-1902 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biological insights into chemotherapy resistance in ovarian cancer

Glasgow, M. A., Argenta, P., Abrahante, J. E., Shetty, M., Talukdar, S., Croonquist, P. A., Khalifa, M. A. & Starr, T. K., May 1 2019, In : International journal of molecular sciences. 20, 9, 2131.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A., Zhang, B., Dougherty, P., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3770-3785 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

CK2 pro-survival role in prostate cancer is mediated via maintenance and promotion of androgen receptor and NFκB p65 expression

Trembley, J. H., Kren, B. T., Abedin, M. J., Shaughnessy, D. P., Li, Y., Dehm, S. M. & Ahmed, K., Jun 2019, In : Pharmaceuticals. 12, 2, 89.

Research output: Contribution to journalArticle

Open Access

Comprehensive behavioral and biochemical outcomes of novel murine models of GM1-gangliosidosis and Morquio syndrome type B

Przybilla, M. J., Ou, L., Tăbăran, A. F., Jiang, X., Sidhu, R., Kell, P. J., Ory, D. S., O'Sullivan, M. G. & Whitley, C. B., Feb 2019, In : Molecular Genetics and Metabolism. 126, 2, p. 139-150 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

Lensing, C. J., Freeman, K. T., Schnell, S. M., Speth, R. C., Zarth, A. T. & Haskell-Luevano, C., Jan 10 2019, In : Journal of medicinal chemistry. 62, 1, p. 144-158 15 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Feasibility Pilot of a Brief Mindfulness Intervention for College Students with Posttraumatic Stress Symptoms and Problem Drinking

Valenstein-Mah, H., Simpson, T. L., Bowen, S., Enkema, M. C., Bird, E. R., In Cho, H. & Larimer, M. E., Jul 15 2019, In : Mindfulness. 10, 7, p. 1255-1268 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Fragmentation Spectra Prediction and DNA Adducts Structural Determination

Carrà, A., Macaluso, V., Villalta, P. W., Spezia, R. & Balbo, S., Dec 1 2019, In : Journal of the American Society for Mass Spectrometry. 30, 12, p. 2771-2784 14 p.

Research output: Contribution to journalArticle

Genome-wide mapping of 8-oxo-7,8-dihydro-2′-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells

Amente, S., Di Palo, G., Scala, G., Castrignanò, T., Gorini, F., Cocozza, S., Moresano, A., Pucci, P., Ma, B., Stepanov, I., Lania, L., Pelicci, P. G., Dellino, G. I. & Majello, B., Jan 10 2019, In : Nucleic acids research. 47, 1, p. 221-236 16 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells

Song, J. M., Im, J., Nho, R. S., Han, Y. H., Upadhyaya, P. & Kassie, F., Mar 2019, In : Molecular Carcinogenesis. 58, 3, p. 321-333 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Rathe, S. K., Popescu, F. E., Johnson, J. E., Watson, A. L., Marko, T. A., Moriarity, B. S., Ohlfest, J. R. & Largaespada, D. A., Dec 1 2019, In : Scientific reports. 9, 1, 358.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Inhaled Furan Selectively Damages Club Cells in Lungs of A/J Mice

Tǎbǎran, A. F., O’Sullivan, M. G., Seabloom, D. E., Vevang, K. R., Smith, W. E., Wiedmann, T. S. & Peterson, L. A., Oct 1 2019, In : Toxicologic Pathology. 47, 7, p. 842-850 9 p.

Research output: Contribution to journalArticle

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. & Hecht, S. S., Jan 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Low levels of siv-specific CD8+ T cells in germinal centers characterizes acute SIV infection

Li, S., Folkvord, J. M., Kovacs, K. J., Wagstaff, R. K., Mwakalundwa, G., Rendahl, A. K., Rakasz, E. G., Connick, E. & Skinner, P. J., Mar 2019, In : PLoS pathogens. 15, 3, e1007311.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations
3 Scopus citations

Mutation of a conserved motif of PP2C.D phosphatases confers SAUR immunity and constitutive activity

Wong, J. H., Spartz, A. K., Park, M., Du, M. & Gray, W. M., Sep 2019, In : Plant physiology. 181, 1, p. 353-366 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

NBGNU: A hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

Ge, Y., Lai, X., Li, J., Yu, R., Zhuang, Z., Sun, G., Cui, X., Zhang, N., Zhao, L., Upadhyaya, P. & Zhong, R., Feb 2019, In : Future Medicinal Chemistry. 11, 4, p. 269-284 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats

Harris, A. C., Muelken, P., Swain, Y., Palumbo, M., Jain, V., Goniewicz, M. L., Stepanov, I. & LeSage, M. G., Oct 1 2019, In : Drug and alcohol dependence. 203, p. 51-60 10 p.

Research output: Contribution to journalArticle

2 Scopus citations