Organization profile
Organization profile
Institute for Therapeutics Discovery and Development (ITDD; Gunda I. Georg, Ph.D., Director, Vadim J. Gurvich, Ph.D., Associate Director) is a research center within the College of Pharmacy that would enable creating an almost complete line from drug discovery to drug development to clinical trials within the University of Minnesota. The Institute's purpose is to conduct research, provide education and offer scientific services to research and business communities in the area of drug discovery and development. The Institute greatly enhances the research capabilities of the University of Minnesota by allowing translation of the biological discoveries to new therapies and bringing drugs to market. The Institute consists of four scientific cores - Medicinal Chemistry, High-Throughput Screening, Lead and Probe Discovery, and Chemical Process Development. The Institute offers a variety of services including drug discovery, HTS and assay development (assay capabilities include absorbance, FRET, fluorescence, luminescence, cell based reporter & viability assays, FP, and high content image analysis assays), computational drug design, lead identification and optimization, medicinal chemistry, organic chemistry, chemical libraries development, chemical process development, scale up, API synthesis under cGMP conditions, CMC support for IND applications, protein purification, analytical services, and others.
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Collaborations and top research areas from the last five years
Profiles
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Eyup Akgun
- Institute for Therapeutics Discovery and Development - Research Professional 6
Person: Researchers
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Narsihmulu Cheryala
- Institute for Therapeutics Discovery and Development - Research Professional 7
Person: Researchers
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Ricardo Gallardo-Macias
- Institute for Therapeutics Discovery and Development - Research Professional 6
Person: Researchers
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Nanodroplet-infused Analgesic Wafer for Transmucosal Opioid-free Treatment of Subacute Oral Pain
Bereiter, D. A. (PI), Gurvich, V. J. (PI), Wang, C. (PI), Gallardo-Macias, R. (Other Role), Goode, A. J. (Other Role) & Rahman, M. M. (Other Role)
TREKKA THERAPEUTICS, LLC, NATIONAL INSTITUTES OF HEALTH (NIH)
9/4/25 → 8/31/26
Project: Research project
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Optimizing anti-microbial immunity by targeting Sts-1
French, J. (PI), Gurvich, V. J. (PI), Wong, H. L. (CoI) & Aziz, F. (Other Role)
THE STATE UNIVERSITY OF NEW YORK, NATIONAL INSTITUTES OF HEALTH (NIH)
7/23/25 → 6/30/29
Project: Research project
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First in humans studies of the pharmacology of boldine
Gurvich, V. J. (PI), Wong, H. L. (CoI), Gallardo-Macias, R. (Other Role), Goode, A. J. (Other Role) & John, K. E. (Other Role)
THE BRONX VETERANS MEDICAL RESEARCH FDN, STATE OF NEW YORK
7/1/25 → 6/30/26
Project: Research project
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Correction to “From Discovery to Clinical Trial: YCT-529, an Oral NonHormonal Male Contraceptive Targeting the Retinoic Acid Receptor Alpha”
Shi, R., Al Noman, M. A., Mannowetz, N., Cheryala, N., Haque, E., Taher, N., Maitra, S., Naqvi, T., Chung, S. S. W., Bakshi, A., Hawkinson, J. E., Wong, H. L., Wolgemuth, D. J. & Georg, G. I., Mar 12 2026, In: Journal of medicinal chemistry. 69, 5, p. 6295 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Development of a Second-Generation RARα Selective Antagonist as an Orally Bioavailable, Effective, Safe, and Reversible Male Contraceptive
Shi, R., John, K. E., Qin, X., Haque, E., Liang, T., Cheryala, N., Li, F., Wong, H. L. & Georg, G. I., May 28 2026, In: Journal of medicinal chemistry. 69, 10, p. 12144-12170 27 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of Focal Adhesion Kinase (FAK) activators to promote intestinal mucosal healing
Gallardo-Macias, R., Wang, Q., Raafat Elsayed, A. A., Liu, G., Wong, H. L., Georg, G. I., Basson, M. D. & Gurvich, V. J., Mar 15 2026, In: European Journal of Medicinal Chemistry. 306, 118606.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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UMN collaboration produces thousands of gallons hand sanitizer
Gurvich, V. J.
5/7/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Are there benefits to eating turmeric and other spices?
Nelson, K.
4/6/20
1 item of Media coverage
Press/Media: Expert Comment or Interview