Projects per year
Organization profile
Institute for Therapeutics Discovery and Development (ITDD; Gunda I. Georg, Ph.D., Director, Vadim J. Gurvich, Ph.D., Associate Director) is a research center within the College of Pharmacy that would enable creating an almost complete line from drug discovery to drug development to clinical trials within the University of Minnesota. The Institute's purpose is to conduct research, provide education and offer scientific services to research and business communities in the area of drug discovery and development. The Institute greatly enhances the research capabilities of the University of Minnesota by allowing translation of the biological discoveries to new therapies and bringing drugs to market. The Institute consists of four scientific cores - Medicinal Chemistry, High-Throughput Screening, Lead and Probe Discovery, and Chemical Process Development. The Institute offers a variety of services including drug discovery, HTS and assay development (assay capabilities include absorbance, FRET, fluorescence, luminescence, cell based reporter & viability assays, FP, and high content image analysis assays), computational drug design, lead identification and optimization, medicinal chemistry, organic chemistry, chemical libraries development, chemical process development, scale up, API synthesis under cGMP conditions, CMC support for IND applications, protein purification, analytical services, and others.
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Network
Profiles
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Narsihmulu Cheryala
- Institute for Therapeutics Discovery and Development - Researcher
Person: Researchers
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Ravi Krishna Dada
- Institute for Therapeutics Discovery and Development - Researcher
Person: Researchers
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A Knowledge Management Framework for Continuous Manufacturing
Gurvich, V. J.
NAT'L INST. FOR PHARM. TECHNOLOGY & EDUC
2/15/22 → 8/31/22
Project: Research project
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Elucidating the biophysics of pre-fibrillar, toxic tau oligomers: from amino acid motifs to neuronal dysfunction
Sachs, J. N., Ashe, K. H., Nelson, K. & Yuan, S.
NIH NAT'L INSTITUTE ON AGING (NIA)
9/30/21 → 5/31/23
Project: Research project
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Lead Optimization of Dopamine D3 Receptor Antagonist for Substance Use Disorder (SUD)
Gurvich, V. J.
9/26/21 → 9/25/22
Project: Research project
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Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy
Singh, G., Liu, P., Yao, K. R., Strasser, J. M., Hlynialuk, C., Leinonen-Wright, K., Teravskis, P. J., Choquette, J. M., Ikramuddin, J., Bresinsky, M., Nelson, K. M., Liao, D., Ashe, K. H., Walters, M. A. & Pockes, S., 2022, (Accepted/In press) In: ACS Chemical Neuroscience. 13, 10Research output: Contribution to journal › Article › peer-review
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Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis
Bresinsky, M., Strasser, J. M., Hubmann, A., Vallaster, B., McCue, B., Fuller, J. L., Singh, G., Nelson, K., Cuellar, M. E., Finzel, B. C., Ashe, K. H., Walters, M. A. & Pockes, S., 2022, (Accepted/In press) In: Archiv der Pharmazie.Research output: Contribution to journal › Article › peer-review
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Cytotoxicity of phenylpironetin analogs and the metabolic fate of pironetin and phenylpironetin
Noman, M. A. A., Huang, D. S., Coulup, S. K., Syeda, S. S., Wong, H. L. & Georg, G. I., Aug 2022, In: Bioorganic Chemistry. 125, 105915.Research output: Contribution to journal › Article › peer-review
Press / Media
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UMN collaboration produces thousands of gallons hand sanitizer
Vadim J Gurvich
5/7/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Are there benefits to eating turmeric and other spices?
Kathryn Nelson
4/6/20
1 item of Media coverage
Press/Media: Expert Comment or Interview