Projects per year
Organization profile
Organization profile
Institute for Therapeutics Discovery and Development (ITDD; Gunda I. Georg, Ph.D., Director, Vadim J. Gurvich, Ph.D., Associate Director) is a research center within the College of Pharmacy that would enable creating an almost complete line from drug discovery to drug development to clinical trials within the University of Minnesota. The Institute's purpose is to conduct research, provide education and offer scientific services to research and business communities in the area of drug discovery and development. The Institute greatly enhances the research capabilities of the University of Minnesota by allowing translation of the biological discoveries to new therapies and bringing drugs to market. The Institute consists of four scientific cores - Medicinal Chemistry, High-Throughput Screening, Lead and Probe Discovery, and Chemical Process Development. The Institute offers a variety of services including drug discovery, HTS and assay development (assay capabilities include absorbance, FRET, fluorescence, luminescence, cell based reporter & viability assays, FP, and high content image analysis assays), computational drug design, lead identification and optimization, medicinal chemistry, organic chemistry, chemical libraries development, chemical process development, scale up, API synthesis under cGMP conditions, CMC support for IND applications, protein purification, analytical services, and others.
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Network
Profiles
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Narsihmulu Cheryala
- Institute for Therapeutics Discovery and Development - Researcher
Person: Researchers
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Ravi Krishna Dada
- Institute for Therapeutics Discovery and Development - Researcher
Person: Researchers
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A Novel Melanoma Vaccine Based on a Shared Neoantigen and a Liquid Polymer Platform
Wang, C., Gurvich, V. J. & Suryanarayanan, R.
4/1/23 → 4/1/24
Project: Research project
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Accelerating drug product development and approval: a critical need in response to national emergencies
Gurvich, V. J.
NAT'L INST. FOR PHARM. TECHNOLOGY & EDUC
2/15/23 → 1/31/24
Project: Research project
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Chemical Synthesis Facility
Gurvich, V. J. & Georg, G.
NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV
9/29/22 → 9/28/23
Project: Research project
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A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing
Wang, Q., Gallardo-Macias, R., Vomhof-DeKrey, E. E., Gupta, R., Golovko, S. A., Golovko, M. Y., Oncel, S., Gurvich, V. J. & Basson, M. D., Jan 2023, In: Current Research in Pharmacology and Drug Discovery. 4, 100147.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation
Joules, A. A., Burrows, T., I. Dosa, P. & Hubel, A., Feb 1 2023, In: Journal of Molecular Liquids. 371, 120937.Research output: Contribution to journal › Article › peer-review
Open Access -
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice
Faber, E. B., Wang, N., John, K., Sun, L., Wong, H. L., Burban, D., Francis, R., Tian, D., Hong, K. H., Yang, A., Wang, L., Elsaid, M., Khalid, H., Levinson, N. M., Schönbrunn, E., Hawkinson, J. E. & Georg, G. I., Feb 9 2023, In: Journal of medicinal chemistry. 66, 3, p. 1928-1940 13 p.Research output: Contribution to journal › Article › peer-review
Press/Media
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UMN collaboration produces thousands of gallons hand sanitizer
Vadim J Gurvich
5/7/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
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Are there benefits to eating turmeric and other spices?
Kathryn Nelson
4/6/20
1 item of Media coverage
Press/Media: Expert Comment or Interview