Institute for Therapeutics Discovery and Development

Organization profile

Organization profile

Institute for Therapeutics Discovery and Development (ITDD; Gunda I. Georg, Ph.D., Director, Vadim J. Gurvich, Ph.D., Associate Director) is a research center within the College of Pharmacy that would enable creating an almost complete line from drug discovery to drug development to clinical trials within the University of Minnesota. The Institute's purpose is to conduct research, provide education and offer scientific services to research and business communities in the area of drug discovery and development. The Institute greatly enhances the research capabilities of the University of Minnesota by allowing translation of the biological discoveries to new therapies and bringing drugs to market. The Institute consists of four scientific cores - Medicinal Chemistry, High-Throughput Screening, Lead and Probe Discovery, and Chemical Process Development. The Institute offers a variety of services including drug discovery, HTS and assay development (assay capabilities include absorbance, FRET, fluorescence, luminescence, cell based reporter & viability assays, FP, and high content image analysis assays), computational drug design, lead identification and optimization, medicinal chemistry, organic chemistry, chemical libraries development, chemical process development, scale up, API synthesis under cGMP conditions, CMC support for IND applications, protein purification, analytical services, and others.

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    Profiles

    No photo of Narsihmulu Cheryala

    Narsihmulu Cheryala

    Person: Researcher

    20002019
    No photo of Matthew E Cuellar

    Matthew E Cuellar

    Person: Researcher

    20062019
    No photo of Peter I Dosa

    Peter I Dosa

    Person: Academic Professional

    20122022

    Projects

    Support Services for synthesis of (-)-Phenserine Tartrate Clinical Grade Material

    Gurvich, V. J.

    NIH NIDA NATL INST ON DRUG AB

    9/30/19 → 9/29/20

    Project: Research project

    D3 Antagonist for Substance Use Disorder

    Gurvich, V. J., Georg, G. & Walters, M. A.

    NIH NIDA NATL INST ON DRUG AB

    9/26/19 → 9/25/21

    Project: Research project

    • MASTER: CRO Support for NCATS Medicinal Chemistry for Lead Optimization

    Gurvich, V. J., Georg, G., Hawkinson, J., Walters, M. A. & Wong, H. L.

    NIHNIDA NATL INST ON DRUG AB

    9/26/19 → 9/25/24

    Project: Research project

    • Research Output

    Diazepam Prodrug Stabilizes Human Aminopeptidase B during Lyophilization

    Rautiola, D., Updyke, J. L., Nelson, K. M. & Siegel, R. A., Feb 3 2020, In : Molecular pharmaceutics. 17, 2, p. 453-460 8 p.

    Research output: Contribution to journal › Article

    • N-butyldeoxygalactonojirimycin induces reversible infertility in male CD rats

    Gupta, V., Hild, S. A., Jakkaraj, S. R., Carlson, E. J., Wong, H. L., Allen, C. L., Georg, G. & Tash, J. S., Jan 1 2020, In : International Journal of Molecular Sciences. 21, 1, 301.

    Research output: Contribution to journal › Article

    Open Access

    • 3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

    Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., Jan 1 2019, In : Journal of Medicinal Chemistry.

    Research output: Contribution to journal › Article

    • 1 Scopus citations