Institute for Therapeutics Discovery and Development

Organization profile

Organization profile

Institute for Therapeutics Discovery and Development (ITDD; Gunda I. Georg, Ph.D., Director, Vadim J. Gurvich, Ph.D., Associate Director) is a research center within the College of Pharmacy that would enable creating an almost complete line from drug discovery to drug development to clinical trials within the University of Minnesota. The Institute's purpose is to conduct research, provide education and offer scientific services to research and business communities in the area of drug discovery and development. The Institute greatly enhances the research capabilities of the University of Minnesota by allowing translation of the biological discoveries to new therapies and bringing drugs to market. The Institute consists of four scientific cores - Medicinal Chemistry, High-Throughput Screening, Lead and Probe Discovery, and Chemical Process Development. The Institute offers a variety of services including drug discovery, HTS and assay development (assay capabilities include absorbance, FRET, fluorescence, luminescence, cell based reporter & viability assays, FP, and high content image analysis assays), computational drug design, lead identification and optimization, medicinal chemistry, organic chemistry, chemical libraries development, chemical process development, scale up, API synthesis under cGMP conditions, CMC support for IND applications, protein purification, analytical services, and others.

Fingerprint Dive into the research topics where Institute for Therapeutics Discovery and Development is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Prodrugs Medicine & Life Sciences
Assays Chemical Compounds
Polyethylene glycols Chemical Compounds
Enzymes Medicine & Life Sciences
Gases Chemical Compounds
Pharmaceutical Preparations Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Throughput Chemical Compounds

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No photo of Peter I Dosa

Peter I Dosa

Person: Academic Professional


Projects 2005 2024

tartaric acid

MASTER: CRO Support for NCATS Medicinal Chemistry for Lead Optimization

Gurvich, V. J., Georg, G., Hawkinson, J., Walters, M. A. & Wong, H. L.



Project: Research project

Pharmaceutical Chemistry
National Center for Advancing Translational Sciences (U.S.)

D3 Antagonist for Substance Use Disorder

Gurvich, V. J., Georg, G. & Walters, M. A.



Project: Research project

Substance-Related Disorders

Research Output 1996 2019

1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., Jan 1 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Plasmodium falciparum
Plasmodium vivax
6 Citations (Scopus)

A fentanyl vaccine alters fentanyl distribution and protects against fentanyl-induced effects in mice and rats

Raleigh, M. D., Baruffaldi, F., Peterson, S. J., Le Naour, M., Harmon, T. M., Vigliaturo, J. R., Pentel, P. R. & Pravetoni, M., Feb 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 2, p. 282-291 10 p.

Research output: Contribution to journalArticle

Open Access
Respiratory Insufficiency
Opioid Analgesics

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Bosnakovski, D., da Silva, M. T., Sunny, S. T., Ener, E. T., Toso, E. A., Yuan, C., Cui, Z., Walters, M. A., Jadhav, A. & Kyba, M., Sep 11 2019, In : Science advances. 5, 9, eaaw7781.

Research output: Contribution to journalArticle

Open Access
gene expression
animal models