Experimental and Clinical Pharmacology

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2012

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

Siddiq, A., Couch, F. J., Chen, G. K., Lindström, S., Eccles, D., Millikan, R. C., Michailidou, K., Stram, D. O., Beckmann, L., Rhie, S. K., Ambrosone, C. B., Aittomäki, K., Amiano, P., Apicella, C., Baglietto, L., Bandera, E. V., Beckmann, M. W., Berg, C. D., Bernstein, L., Blomqvist, C. & 31 others, Brauch, H., Brinton, L., Bui, Q. M., Buring, J. E., Buys, S. S., Campa, D., Carpenter, J. E., Chasman, D. I., Chang-Claude, J., Chen, C., Clavel-Chapelon, F., Cox, A., Cross, S. S., Czene, K., Deming, S. L., Diasio, R. B., Ryan Diver, W., Dunning, A. M., Durcan, L., Ekici, A. B., Fasching, P. A., Feigelson, H. S., Fejerman, L., Figueroa, J. D., Fletcher, O., Flesch-Janys, D., Gaudet, M. M., Gerty, S. M., Rodriguez-Gil, J. L., Lee, A. M. & Australian Breast Cancer Tissue Bank Investigators, Jan 1 2012, In : Human molecular genetics. 21, 24, p. 5373-5384 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

A model to predict mortality following Pseudomonas aeruginosa bacteremia

Hirsch, E. B., Cottreau, J. M., Chang, K. T., Caeiro, J. P., Johnson, M. L. & Tam, V. H., Jan 1 2012, In : Diagnostic Microbiology and Infectious Disease. 72, 1, p. 97-102 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
8 Scopus citations

Autosomal dominant mesomandibular fibro-osseous dysplasia: A self-resolving inherited fibro-osseous lesion of the jaws

Koutlas, I. G., Forsman, C. L., Kyrkanides, S., Oetting, W. S. & Petryk, A., Dec 1 2012, In : Frontiers in Physiology. 3 DEC, Article 458.

Research output: Contribution to journalArticle

Chronic doxorubicin cardiotoxicity modulates cardiac cytochrome P450-mediated arachidonic acid metabolism in rats

Alsaad, A. M. S., Zordoky, B. N. M., El-Sherbeni, A. A. & El-Kadi, A. O. S., Nov 1 2012, In : Drug Metabolism and Disposition. 40, 11, p. 2126-2135 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats

Pravetoni, M., Raleigh, M. D., Le Naour, M., Tucker, A. M., Harmon, T. M., Jones, J. M., Birnbaum, A. K., Portoghese, P. S. & Pentel, P. R., Jun 29 2012, In : Vaccine. 30, 31, p. 4617-4624 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., Steer, C. J., Modiano, J. F. & Subramanian, S., Sep 5 2012, In : PloS one. 7, 9, e43720.

Research output: Contribution to journalArticle

42 Scopus citations

Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

Kou, J., Song, M., Pattanayak, A., Lim, J. E., Yang, J., Cao, D., Li, L. & Fukuchi, K. I., Mar 1 2012, In : Journal of Neuroimmunology. 244, 1-2, p. 70-83 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits.

Spaulding, A. R., Satterwhite, E. A., Lin, Y. C., Chuang-Smith, O. N., Frank, K. L., Merriman, J. A., Schaefers, M. M., Yarwood, J. M., Peterson, M. L. & Schlievert, P. M., 2012, In : Frontiers in Cellular and Infection Microbiology. 2, 1 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cytotoxic purine nucleoside analogues bind to A 1, A 2A, and A 3 adenosine receptors

Jensen, K., Johnson, LA. A., Jacobson, P. A., Kachler, S., Kirstein, M. N., Lamba, J. & Klotz, K. N., May 1 2012, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 385, 5, p. 519-525 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
25 Scopus citations

Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients

Oetting, W. S., Guan, W., Schladt, D. P., Leduc, R. E., Jacobson, P. A., Matas, A. J., Chinnakotla, S., Schröppel, B., Murphy, B. T. & Israni, A. K., Dec 1 2012, In : Liver Transplantation. 18, 12, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
42 Scopus citations

EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Taga, M., Mechanic, L. E., Hagiwara, N., Vähäkangas, K. H., Bennett, W. P., Alavanja, M. C. R., Welsh, J. A., Khan, M. A., Lee, A., Diasio, R., Edell, E., Bungum, A., Jang, J. S., Yang, P., Jen, J. & Harris, C. C., Jun 1 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 6, p. 988-992 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Enhanced detection of hydrogen sulfide generated in cell culture using an agar trap method

Kartha, R. V., Zhou, J., Hovde, L. B., Cheung, B. W. Y. & Schröder, H., Apr 1 2012, In : Analytical Biochemistry. 423, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1

Schaefers, M. M., Breshears, L. M., Anderson, M. J., Lin, Y. C., Grill, A. E., Panyam, J., Southern, P. J., Schlievert, P. M. & Peterson, M. L., Mar 14 2012, In : PloS one. 7, 3, e32813.

Research output: Contribution to journalArticle

14 Scopus citations

Evaluation of a daptomycin dose-optimization protocol

Tran, T. T., Palmer, H. R., Weston, J., Hirsch, E. B., Shah, D. N., Cottreau, J., Tam, V. H. & Garey, K. W., Jun 1 2012, In : American Journal of Health-System Pharmacy. 69, 11, p. 979-984 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
9 Scopus citations
13 Scopus citations

Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: Results from a kidney transplant consortium

Jacobson, P. A., Schladt, D., Israni, A., Oetting, W. S., Lin, Y. C., Leduc, R., Guan, W., Lamba, V. & Matas, A. J., Mar 27 2012, In : Transplantation. 93, 6, p. 624-631 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genetic and environmental correlates of topiramate-induced cognitive impairment

Cirulli, E. T., Urban, T. J., Marino, S. E., Linney, K. N., Birnbaum, A. K., Depondt, C., Attix, D. K., Radtke, R. A. & Goldstein, D. B., Jan 1 2012, In : Epilepsia. 53, 1, p. e5-e8

Research output: Contribution to journalArticle

14 Scopus citations

Genetic variation that predicts platinum sensitivity reveals the role of miR-193b&z.ast; in chemotherapeutic susceptibility

Ziliak, D., Gamazon, E. R., LaCroix, B., Im, H. K., Wen, Y. & Huang, R. S., Sep 1 2012, In : Molecular Cancer Therapeutics. 11, 9, p. 2054-2061 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Ghoussaini, M., Fletcher, O., Michailidou, K., Turnbull, C., Schmidt, M. K., Dicks, E., Dennis, J., Wang, Q., Humphreys, M. K., Luccarini, C., Baynes, C., Conroy, D., Maranian, M., Ahmed, S., Driver, K., Johnson, N., Orr, N., Dos Santos Silva, I., Waisfisz, Q., Meijers-Heijboer, H. & 162 others, Uitterlinden, A. G., Rivadeneira, F., Hall, P., Czene, K., Irwanto, A., Liu, J., Nevanlinna, H., Aittom Currency Signki, K., Blomqvist, C., Meindl, A., Schmutzler, R. K., Müller-Myhsok, B., Lichtner, P., Chang-Claude, J., Hein, R., Nickels, S., Flesch-Janys, D., Tsimiklis, H., Makalic, E., Schmidt, D., Bui, M., Hopper, J. L., Apicella, C., Park, D. J., Southey, M., Hunter, D. J., Chanock, S. J., Broeks, A., Verhoef, S., Hogervorst, F. B. L., Fasching, P. A., Lux, M. P., Beckmann, M. W., Ekici, A. B., Sawyer, E., Tomlinson, I., Kerin, M., Marme, F., Schneeweiss, A., Sohn, C., Burwinkel, B., Guénel, P., Truong, T., Cordina-Duverger, E., Menegaux, F., Bojesen, S. E., Nordestgaard, B. G., Nielsen, S. F., Flyger, H., Milne, R. L., Alonso, M. R., Gonzlez-Neira, A., Ben-tez, J., Anton-Culver, H., Ziogas, A., Bernstein, L., Dur, C. C., Brenner, H., Müller, H., Arndt, V., Stegmaier, C., Justenhoven, C., Brauch, H., Brüning, T., Shan, W. G., Eilber, U., Dörk, T., Schürmann, P., Bremer, M., Hillemanns, P., Bogdanova, N. V., Antonenkova, N. N., Rogov, Y. I., Karstens, J. H., Bermisheva, M., Prokofieva, D., Khusnutdinova, E., Lindblom, A., Margolin, S., Mannermaa, A., Kataja, V., Kosma, V. M., Hartikainen, J. M., Lambrechts, D., Yesilyurt, B. T., Floris, G., Leunen, K., Manoukian, S., Bonanni, B., Fortuzzi, S., Peterlongo, P., Couch, F. J., Wang, X., Stevens, K., Lee, A., Giles, G. G., Baglietto, L., Severi, G., McLean, C., Alnæs, G. G., Kristensen, V., Bcrrensen-Dale, A. L., John, E. M., Miron, A., Winqvist, R., Pylk Currency Signs, K., Jukkola-Vuorinen, A., Kauppila, S., Andrulis, I. L., Glendon, G., Mulligan, A. M., Devilee, P., Van Asperen, C. J., Tollenaar, R. A. E. M., Seynaeve, C., Figueroa, J. D., Garcia-Closas, M., Brinton, L., Lissowska, J., Hooning, M. J., Hollestelle, A., Oldenburg, R. A., Van Den Ouweland, A. M. W., Cox, A., Reed, M. W. R., Shah, M., Jakubowska, A., Jan, L., Jaworska, K., Durda, K., Jones, M., Schoemaker, M., Ashworth, A., Swerdlow, A., Beesley, J., Chen, X., Muir, K. R., Lophatananon, A., Rattanamongkongul, S., Chaiwerawattana, A., Kang, D., Yoo, K. Y., Noh, D. Y., Shen, C. Y., Yu, J. C., Wu, P. E., Hsiung, C. N., Perkins, A., Swann, R., Velentzis, L., Eccles, D. M., Tapper, W. J., Gerty, S. M., Graham, N. J., Ponder, B. A. J., Chenevix-Trench, G., Pharoah, P. D. P., Lathrop, M., Dunning, A. M., Rahman, N., Peto, J. & Easton, D. F., Mar 2012, In : Nature Genetics. 44, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

206 Scopus citations

Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate

Frazier-Wood, A. C., Aslibekyan, S., Borecki, I. B., Hopkins, P. N., Lai, C. Q., Ordovas, J. M., Straka, R. J., Tiwari, H. K. & Arnett, D. K., Oct 1 2012, In : Pharmacogenetics and genomics. 22, 10, p. 750-757 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Glycerol monolaurate antibacterial activity in broth and biofilm cultures

Schlievert, P. M. & Peterson, M. L., Jul 11 2012, In : PloS one. 7, 7, e40350.

Research output: Contribution to journalArticle

69 Scopus citations
40 Scopus citations

Identification of a novel percent mammographic density locus at 12q24

Stevens, K. N., Lindstrom, S., Scott, C. G., Thompson, D., Sellers, T. A., Wang, X., Wang, A., Atkinson, E., Rider, D. N., Eckel-passow, J. E., Varghese, J. S., Audley, T., Brown, J., Leyland, J., Luben, R. N., Warren, R. M. L., Loos, R. J. F., Wareham, N. J., Li, J., Hall, P. & 34 others, Liu, J., Eriksson, L., Czene, K., Olson, J. E., Shane pankratz, V., Fredericksen, Z., Diasio, R. B., Lee, A. M., Heit, J. A., Deandrade, M., Goode, E. L., Vierkant, R. A., Cunningham, J. M., Armasu, S. M., Weinshilboum, R., Fridley, B. L., Batzler, A., Ingle, J. N., Boyd, N. F., Paterson, A. D., Rommens, J., Martin, L. J., Hopper, J. L., Southey, M. C., Stone, J., Apicella, C., Kraft, P., Hankinson, S. E., Hazra, A., Hunter, D. J., Easton, D. F., Couch, F. J., Tamimi, R. M. & Vachon, C. M., Jul 1 2012, In : Human molecular genetics. 21, 14, p. 3299-3305 7 p., dds158.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of novel germline polymorphisms governing capecitabine sensitivity

O'Donnell, P. H., Stark, A. L., Gamazon, E. R., Wheeler, H. E., McIlwee, B. E., Gorsic, L., Im, H. K., Huang, R. S., Cox, N. J. & Dolan, M. E., Aug 15 2012, In : Cancer. 118, 16, p. 4063-4073 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses

Spaulding, A. R., Lin, Y. C., Merriman, J. A., Brosnahan, A. J., Peterson, M. L. & Schlievert, P. M., Jul 20 2012, In : Vaccine. 30, 34, p. 5099-5109 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Inhibition of tumor angiogenesis and growth by nanoparticle-mediated p53 gene therapy in mice

Prabha, S., Sharma, B. & Labhasetwar, V., Aug 1 2012, In : Cancer gene therapy. 19, 8, p. 530-537 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Interaction of n-acetylcysteine and cysteine in human plasma

Radtke, K. K., Coles, L. D., Mishra, U., Orchard, P. J., Holmay, M. & Cloyd, J. C., Dec 2012, In : Journal of Pharmaceutical Sciences. 101, 12, p. 4653-4659 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Isoprenoids and related pharmacological interventions: Potential application in Alzheimer's disease

Li, L., Zhang, W., Cheng, S., Cao, D. & Parent, M., Aug 2012, In : Molecular neurobiology. 46, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Meta-Analyses of KIF6 Trp719Arg in Coronary Heart Disease and Statin Therapeutic Effect

Peng, P., Lian, J., Huang, R. S., Xu, L., Huang, Y., Ba, Y., Yang, X., Huang, X., Dong, C., Zhang, L., Ye, M., Zhou, J. & Duan, S., Dec 7 2012, In : PloS one. 7, 12, e50126.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

Trottier, J., Białek, A., Caron, P., Straka, R. J., Heathcote, J., Milkiewicz, P. & Barbier, O., Apr 1 2012, In : Digestive and Liver Disease. 44, 4, p. 303-310 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mixed effects modeling of proliferation rates in cell-based models: Consequence for pharmacogenomics and Cancer

Im, H. K., Gamazon, E. R., Stark, A. L., Huang, R. S., Cox, N. J. & Dolan, M. E., Feb 1 2012, In : PLoS genetics. 8, 2, e1002525.

Research output: Contribution to journalArticle

21 Scopus citations

Molecular testing in congenital adrenal hyperplasia due to 21α-hydroxylase deficiency in the era of newborn screening

Sarafoglou, K. M., Lorentz, C. P., Otten, N., Oetting, W. S. & Grebe, S. K. G., Jul 1 2012, In : Clinical Genetics. 82, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

N-hexanoyl, N-octanoyl and N-decanoyl chitosans: Binding affinity, cell uptake, and transfection

Layek, B. & Singh, J., Jun 20 2012, In : Carbohydrate Polymers. 89, 2, p. 403-410 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
4 Scopus citations

Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors

Mitra, A. K., Kirstein, M. N., Khatri, A., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A. & Lamba, J. K., Jul 1 2012, In : Pharmacogenomics. 13, 9, p. 1009-1021 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., Steer, C. J., Modiano, J. F. & Subramanian, S., Jan 1 2012, In : Bone. 50, 1, p. 171-181 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine

Khatri, A., Brundage, R. C., Hull, J. M., Williams, B. W., Yee, D. & Kirstein, M. N., Mar 1 2012, In : AAPS Journal. 14, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Bishop, J. R., Chae, S. S., Patel, S., Moline, J. & Ellingrod, V. L., Aug 30 2012, In : Psychiatry Research. 199, 1, p. 74-76 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia

Houston, J. P., Kohler, J., Bishop, J. R., Ellingrod, V. L., Ostbye, K. M., Zhao, F., Conley, R. R., Hoffmann, V. P. & Fijal, B. A., Aug 2012, In : Journal of Clinical Psychiatry. 73, 8, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women

Dumond, J. B., Nicol, M. R., Kendrick, R. N., Garonzik, S. M., Patterson, K. B., Cohen, M. S., Forrest, A. & Kashuba, A. D. M., Dec 1 2012, In : Clinical Pharmacokinetics. 51, 12, p. 809-822 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Population pharmacokinetics of carbamazepine in elderly patients

Punyawudho, B., Ramsay, E. R., Brundage, R. C., MacIas, F. M., Collins, J. F. & Birnbaum, A. K., Apr 1 2012, In : Therapeutic drug monitoring. 34, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
13 Scopus citations

Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder

Holman, C. J., Karger, A., Mullan, B. D., Brundage, R. & Balfour, H. H., Sep 1 2012, In : Clinical Transplantation. 26, 5, p. 741-747 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry

Bathena, S. P., Huang, J., Epstein, A. A., Gendelman, H. E., Boska, M. D. & Alnouti, Y., Apr 15 2012, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 893-894, p. 15-20 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study

Irvin, M. R., Zhang, Q., Kabagambe, E. K., Perry, R. T., Straka, R. J., Tiwari, H. K., Borecki, I. B., Shimmin, L. C., Stuart, C., Zhong, Y., Hixson, J. E. & Arnett, D. K., May 1 2012, In : Pharmacogenetics and genomics. 22, 5, p. 367-372 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Risperidone-associated prolactin elevation and markers of bone turnover during acute treatment

Bishop, J. R., Rubin, L. H., Reilly, J. L., Pavuluri, M. N. & Sweeney, J. A., Jun 2012, In : Therapeutic Advances in Psychopharmacology. 2, 3, p. 95-102 8 p.

Research output: Contribution to journalArticle

13 Scopus citations