Experimental and Clinical Pharmacology

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2018

Genome-Wide Association Meta-Analysis for Acute Rejection of Kidney Transplants

Israni, A. K., Jacobson, P. A., Guan, W., Dorr, C. R., van Setten, J., de Borst, M. H., Stapleton, C. P., Phelan, P. J., Conlon, P. J., Birdwell, K. A., Reindl-Schwaighofer, R., Heinzel, A., Bakker, S. J., Cavelleri, G., Oetting, W. S., Schladt, D. P., Kwok, P-Y., Eikmans, M., Snieder, H., Wu, B. & 5 others, Bassaganyas, L., Yang, J., van der Most, P. J., Asselbergs, F. W. & Keating, B., 2018, In : Transplantation. 102, p. S27

Research output: Contribution to journalArticle

15 Scopus citations

High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia

Chernick, D., Ortiz-Valle, S., Jeong, A., Swaminathan, S. K., Kandimalla, K. K., Rebeck, G. W. & Li, L., Dec 2018, In : Journal of Neurochemistry. 147, 5, p. 647-662 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

IL-1β reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis

Al-Kofahi, M., Omura, S., Tsunoda, I., Sato, F., Becker, F., Gavins, F. N. E., Woolard, M. D., Pattillo, C., Zawieja, D., Muthuchamy, M., Gashev, A., Shihab, I., Ghoweba, M., Von der Weid, P. Y., Wang, Y. & Alexander, J. S., Nov 2018, In : Biomedicine and Pharmacotherapy. 107, p. 1591-1600 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Incorporation of lipolysis in monolayer permeability studies of lipid-based oral drug delivery systems

Sadhukha, T., Layek, B. & Prabha, S., Apr 1 2018, In : Drug Delivery and Translational Research. 8, 2, p. 375-386 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access
2 Scopus citations

Iron supplements in nursing home patients associated with reduced carbamazepine absorption

Ahn, J. E., Bathena, S. P. R., Brundage, R. C., Conway, J. M., Leppik, I. E. & Birnbaum, A. K., Nov 2018, In : Epilepsy Research. 147, p. 115-118 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lamotrigine clearance increases by 5 weeks gestational age: Relationship to estradiol concentrations and gestational age

Karanam, A., Pennell, P. B., French, J. A., Harden, C. L., Allien, S., Lau, C., Barnard, S., Callisto, S. P. & Birnbaum, A. K., Oct 2018, In : Annals of Neurology. 84, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Polepally, A. R., Brundage, R. C., Remmel, R. P., Leppik, I. E., Pennell, P. B., White, J. R., Ramsay, R. E., Kistner, B. M. & Birnbaum, A. K., Sep 2018, In : Epilepsia. 59, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Letting the patient decide: A case report of self-administered sedation during mechanical ventilation

Hetland, B., Hayes, S. M., Skaar, D. J., Tracy, M. F., Weinert, C. R. & Chlan, L., Feb 1 2018, In : Critical care nurse. 38, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Open Access

Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues

Suazo, K. F. G., Hurben, A. K., Liu, K., Xu, F., Thao, P., Chava, S., Li, L. & Distefano, M. D., Sep 1 2018, In : Current protocols in chemical biology. 10, 3, p. e46

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Methods and tools for assessing the impact of genetic variations: The 2017 Annual Scientific Meeting of the Human Genome Variation Society

Oetting, W. S., Béroud, C., Brenner, S. E., Greenblatt, M. S., Karchin, R. & Mooney, S. D., Mar 2018, In : Human mutation. 39, 3, p. 454-458 5 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
6 Scopus citations
Open Access
5 Scopus citations

Nano-engineered mesenchymal stem cells increase therapeutic efficacy of anticancer drug through true active tumor targeting

Layek, B., Sadhukha, T., Panyam, J. & Prabha, S., Jun 2018, In : Molecular Cancer Therapeutics. 17, 6, p. 1196-1206 11 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

NPHP1 (Nephrocystin-1) gene deletions cause adult-onset ESRD

Snoek, R., Van Setten, J., Keating, B. J., Israni, A. K., Jacobson, P. A., Oetting, W. S., Matas, A. J., Mannon, R. B., Zhang, Z., Zhang, W., Hao, K., Murphy, B., Reindl-Schwaighofer, R., Heinzl, A., Oberbauer, R., Viklicky, O., Conlon, P. J., Stapleton, C. P., Bakker, S. J. L., Snieder, H. & 5 others, Peters, E. D. J., Van Der Zwaag, B., Knoers, N. V. A. M., De Borst, M. H. & Van Eerde, A. M., Jun 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Opioid dose-And route-dependent efficacy of oxycodone and heroin vaccines in rats

Raleigh, M. D., Laudenbach, M., Baruffaldi, F., Peterson, S. J., Roslawski, M. J., Birnbaum, A. K., Carroll, F. I., Runyon, S. P., Winston, S., Pentel, P. R. & Pravetoni, M., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 346-353 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Optic nerve as a source of activated retinal microglia post-injury

Heuss, N. D., Pierson, M. J., Roehrich, H., Mc Pherson, S. W., Gram, A. L., Li, L. & Gregerson, D. S., Jul 23 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Rubin, L. H., Li, S., Yao, L., Keedy, S. K., Reilly, J. L., Hill, S. K., Bishop, J. R., Sue Carter, C., Pournajafi-Nazarloo, H., Drogos, L. L., Gershon, E., Pearlson, G. D., Tamminga, C. A., Clementz, B. A., Keshavan, M. S., Lui, S. & Sweeney, J. A., Dec 2018, In : Schizophrenia Research. 202, p. 173-179 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Plasma lipoproteome in Alzheimer's disease: A proof-of-concept study

Li, D., Huang, F., Zhao, Y., Villata, P. W., Griffin, T. J., Zhang, L., Li, L. & Yu, F., Sep 20 2018, In : Clinical Proteomics. 15, 1, 31.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls

Shafee, R., Nanda, P., Padmanabhan, J. L., Tandon, N., Alliey-Rodriguez, N., Kalapurakkel, S., Weiner, D. J., Gur, R. E., Keefe, R. S. E., Hill, S. K., Bishop, J. R., Clementz, B. A., Tamminga, C. A., Gershon, E. S., Pearlson, G. D., Keshavan, M. S., Sweeney, J. A., McCarroll, S. A. & Robinson, E. B., Dec 1 2018, In : Translational psychiatry. 8, 1, 78.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins

Baruffaldi, F., Kelcher, A. H., Laudenbach, M., Gradinati, V., Limkar, A., Roslawski, M., Birnbaum, A. K., Lees, A., Hassler, C., Runyon, S. & Pravetoni, M., Nov 5 2018, In : Molecular pharmaceutics. 15, 11, p. 4947-4962 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Open Access
28 Scopus citations

Rescue therapies for seizure emergencies: New modes of administration

Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 2018, In : Epilepsia. 59, p. 207-215 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Sensitive Determination of Fentanyl in Low-Volume Serum Samples by LC-MS/MS

Swaminathan, S. K., Fisher, J. & Kandimalla, K. K., Oct 1 2018, In : AAPS PharmSciTech. 19, 7, p. 2812-2817 6 p.

Research output: Contribution to journalArticle

Serum sodium response to hypertonic saline infusion therapy in traumatic brain injury

Chapman, S. A., Irwin, E. D., Thunselle, M., Ronk, A., Reicks, P., Curran, B., Rangarajan, K., Tam, H. & Beilman, G. J., Feb 2018, In : Journal of Clinical Neuroscience. 48, p. 147-152 6 p.

Research output: Contribution to journalArticle

Status epilepticus in the elderly

Leppik, I. E., Oct 2018, In : Epilepsia. 59, p. 140-143 4 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density

Hottman, D., Cheng, S., Gram, A., LeBlanc, K., Yuan, L. L. & Li, L., Mar 1 2018, In : Neuroscience. 373, p. 207-217 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination

Scheibner, A., Remmel, R. P., Schladt, D., Oetting, W. S., Guan, W., Wu, B., Dorr, C., Israni, A. & Jacobson, P. A., Jul 2018, In : Pharmacotherapy. 38, 7, p. e46-e52

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
6 Scopus citations

Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses

Omura, S., Kawai, E., Sato, F., Martinez, N. E., Minagar, A., Al-Kofahi, M., Yun, J. W., Cvek, U., Trutschl, M., Alexander, J. S. & Tsunoda, I., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue

Nicol, M. R., Brewers, L. M., Kashuba, A. D. M. & Sykes, C., Jan 2 2018, In : AIDS. 32, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

Wu, J. F., Muthusamy, A., Al-Ghalith, G. A., Knights, D., Guo, B., Wu, B., Remmel, R. P., Schladt, D. P., Alegre, M. L., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Dec 2018, In : Clinical Transplantation. 32, 12, e13436.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Chen, A., Smith, K. P., Whitfield, B. A., Zucchi, P. C., Lasco, T. M., Bias, T. E., Kirby, J. E. & Hirsch, E. B., Aug 2017, In : Diagnostic Microbiology and Infectious Disease. 88, 4, p. 365-367 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Adenosine Triphosphate Quantification Correlates Poorly with Microbial Contamination of Duodenoscopes

Olafsdottir, L. B., Wright, S. B., Smithey, A., Heroux, R., Hirsch, E. B., Chen, A., Lane, B., Sawhney, M. S. & Snyder, G. M., Jun 1 2017, In : Infection Control and Hospital Epidemiology. 38, 6, p. 678-684 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
7 Scopus citations

Analysis of falls in patients with epilepsy enrolled in the perampanel phase III randomized double-blind studies

Leppik, I. E., Yang, H., Williams, B., Zhou, S., Fain, R., Patten, A., Bibbiani, F. & Laurenza, A., Jan 1 2017, In : Epilepsia. 58, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Antiseizure, antidepressant, and antipsychotic medication prescribing in elderly nursing home residents

Bathena, S. P. R., Leppik, I. E., Kanner, A. M. & Birnbaum, A. K., Apr 1 2017, In : Epilepsy and Behavior. 69, p. 116-120 5 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 2017, In : PM and R. 9, 8, p. 743-750 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
3 Scopus citations

Assessment of Fosfomycin for Complicated or Multidrug-Resistant Urinary Tract Infections: Patient Characteristics and Outcomes

Giancola, S. E., Mahoney, M. V., Hogan, M. D., Raux, B. R., McCoy, C. & Hirsch, E. B., Jan 1 2017, In : Chemotherapy. p. 100-104 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

Hicks, J. K., Sangkuhl, K., Swen, J. J., Ellingrod, V. L., Müller, D. J., Shimoda, K., Bishop, J. R., Kharasch, E. D., Skaar, T. C., Gaedigk, A., Dunnenberger, H. M., Klein, T. E., Caudle, K. E. & Stingl, J. C., Jul 1 2017, In : Clinical pharmacology and therapeutics. 102, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Cognitive burden of anticholinergic medications in psychotic disorders

Eum, S., Hill, S. K., Rubin, L. H., Carnahan, R. M., Reilly, J. L., Ivleva, E. I., Keedy, S. K., Tamminga, C. A., Pearlson, G. D., Clementz, B. A., Gershon, E. S., Keshavan, M. S., Keefe, R. S. E., Sweeney, J. A. & Bishop, J. R., Dec 2017, In : Schizophrenia Research. 190, p. 129-135 7 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Collaborative Counseling Considerations for Pharmacogenomic Tests

Zierhut, H. A., Campbell, C. A., Mitchell, A. G., Lemke, A. A., Mills, R. & Bishop, J. R., Sep 2017, In : Pharmacotherapy. 37, 9, p. 990-999 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity

Spaulding, A., Takrouri, K., Mahalingam, P., Cleary, D. C., Cooper, H. D., Zucchi, P., Tear, W., Koleva, B., Beuning, P. J., Hirsch, E. B. & Aggen, J. B., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5310-5321 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites

Flora, D. R., Rettie, A. E., Brundage, R. C. & Tracy, T. S., Jan 1 2017, In : Journal of Clinical Pharmacology. 57, 3, p. 382-393 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Discovering drugs to overcome chemoresistance in ovarian cancers based on the cancer genome atlas tumor transcriptome profile

Wang, F., Chang, J. T. H., Zhang, Z., Morrison, G., Nath, A., Bhutra, S. & Huang, R. S., Jan 1 2017, In : Oncotarget. 8, 70, p. 115102-115113 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies

Geeleher, P., Zhang, Z., Wang, F., Gruener, R. F., Nath, A., Morrison, G., Bhutra, S., Grossman, R. L. & Huang, R. S., Oct 2017, In : Genome Research. 27, 10, p. 1743-1751 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Duodenoscope hang time does not correlate with risk of bacterial contamination

Heroux, R., Sheppard, M., Wright, S. B., Sawhney, M., Hirsch, E. B., Kalaidjian, R. & Snyder, G. M., Apr 1 2017, In : American journal of infection control. 45, 4, p. 360-364 5 p.

Research output: Contribution to journalArticle

2 Scopus citations