Experimental and Clinical Pharmacology

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1965

EXPERIMENTAL USE OF A SINGLE MECHANICAL VENTRICLE TO REPLACE THE DOG'S

PIERCE, W. S., MORRIS, L., GARDINER, B. N., BURNEY, R. G., LEPPIK, I., MALMUD, L. & DANIELSON, G. K., Dec 1 1965, In : Transactions - American Society for Artificial Internal Organs. 11, p. 271-276 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Total heart replacement by a single intrathoracic blood pump

Pierce, W. S., Gardiner, B. N., Morris, L., Burney, R. G., Leppik, I. E. & Danielson, G. K., Sep 1965, In : Journal of Surgical Research. 5, 9, p. 387-394 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
1971

Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

Hornemann, U. & Cloyd, J. C., Dec 1 1971, In : Journal of the Chemical Society D: Chemical Communications. 7, p. 301-302 2 p.

Research output: Contribution to journalArticle

24 Scopus citations
1975

Anticonvulsant activity of phenytoin in combination with phenobarbital

Leppik, I. E. & Sherwin, A. L., Jan 1 1975, In : Clinical Research. 23, 5, p. 642A

Research output: Contribution to journalArticle

1976

Anticonvulsant activity of phenobarbital and phenytoin in combination

Leppik, I. E. & Sherwin, A. L., Jan 1 1976, In : Pharmacologist. 18, 2

Research output: Contribution to journalArticle

Correlation between red cell and free plasma phenytoin levels in renal disease

Sherwin, A. L., Harvey, C. D., Leppik, I. E. & Gonda, A., Sep 1976, In : Neurology. 26, 9, p. 874-878 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Diplopia and involuntary eye closure in spontaneous cerebellar hemorrhage

Messert, B., Leppik, I. E. & Sato, S., Jan 1 1976, In : Stroke. 7, 3, p. 305-307 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
1977

Anticonvulsant activity of phenobarbital and phenytoin in combination

Leppik, I. E. & Sherwin, A. L., Dec 1 1977, In : Journal of Pharmacology and Experimental Therapeutics. 200, 3, p. 570-575 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Diatrizoate in computed cranial tomography: A quantitative study

Lepplk, I. E., Thompson, C. J., Ethier, R. & Sherw1n, A. L., Jan 1 1977, In : Investigative Radiology. 12, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
4 Scopus citations

Hydrochloric acid for the correction of severe metabolic alkalosis: an alternate approach.

Johnson, C. A. & Cloyd, J. C., Mar 1 1977, In : Journal of the Kentucky Medical Association. 75, 3, p. 121-123 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Salivary levels of anticonvulsants: A practical approach to drug monitoring

McAuliffe, J. J., Sherwin, A. L., Leppik, I. E., Fayle, S. A. & Pippenger, C. E., May 1977, In : Neurology. 27, 5, p. 409-413 5 p.

Research output: Contribution to journalArticle

110 Scopus citations
1978

Amikacin pharmacokinetics: effect of age on elimination

Rotschafer, J. C., Zaske, D. E. & Cipolle, R. J., Jan 1 1978, In : Clinical Research. 26, 3, p. 594A

Research output: Contribution to journalArticle

Clonazepam in the treatment of epilepsy

Matthews, S. J., Pepin, S. M. & Leppik, I. E., Jan 1 1978, In : Minnesota medicine. 61, 7, p. 439-442 4 p.

Research output: Contribution to journalArticle

Concentration-time profile of phenytoin after admixture with small volumes of intravenous fluids

Cloyd, J. C., Bosch, D. E. & Sawchuk, R. J., Jan 1 1978, In : American Journal of Hospital Pharmacy. 35, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intravenous phenytoin: Clinical and pharmacokinetic aspects

Cranford, R. E., Leppik, I. E., Patrick, B., Anderson, C. B. & Kostick, B., 1978, In : Neurology. 28, 9 I, p. 874-880 7 p.

Research output: Contribution to journalArticle

126 Scopus citations

Progressive Sensory Loss One Year After Bullet Injury of Spinal Cord

Nino, H. E., Leppik, I. E., Lai, C. W. & Martin, S., Sep 8 1978, In : JAMA: The Journal of the American Medical Association. 240, 11, p. 1173-1174 2 p.

Research output: Contribution to journalArticle

11 Scopus citations
1979

Comparative study of cefaclor and amoxicillin in treatment of urinary tract infection

Rotschafer, J., Crossley, K., Zaske, D. & Viste, R., Sep 1979, In : Urology. 14, 3, p. 233-236 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Compliance and variability of plasma phenytoin levels in epileptic patients

Leppik, I. E., Cloyd, J. C., Sawchuk, R. J. & Pepin, S. M., Jan 1 1979, In : Therapeutic drug monitoring. 1, 4, p. 475-483 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Effect of influenza vaccination on plasma phenytoin concentrations

Sawchuk, R. J., Rector, T. S., Fordice, J. J. & Leppik, I. E., Jan 1 1979, In : Therapeutic drug monitoring. 1, 2, p. 285-288 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Increased Clearance of Phenytoin during Infectious Mononucleosis

Leppik, I. E., Ramani, V., Sawchuk, R. J. & Gumnit, R. J., Mar 1 1979, In : New England Journal of Medicine. 300, 9, p. 481-482 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

Intravenous Phenytoin and Phenobarbital: Anticonvulsant Action, Brain Content, and Plasma Binding in Rat

Leppik, I. E. & Sherwin, A. L., Jun 1979, In : Epilepsia. 20, 3, p. 201-207 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Intravenous phenytoin in acute treatment of seizures

Cranford, R. E., Leppik, I. E., Patrick, B., Anderson, C. B. & Kostick, B., Nov 1979, In : Neurology. 29, 11, p. 1474-1479 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Pharmacokinetic Properties of Thiopental in Two Patients Treated for Uncontrollable Seizures

Cloyd, J. C., Wright, B. D. & Perrier, D., Jun 1979, In : Epilepsia. 20, 3, p. 313-318 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The pharmacokinetics of valproic acid in children

Kriel, R. L., Cloyd, J. C. & Green, K. H., Jan 1 1979, In : Annals of Neurology. 6, 2, 1 p.

Research output: Contribution to journalArticle

6 Scopus citations
1980

Availability of diazepam from plastic containers

Cloyd, J. C., Vezeau, C. & Miller, K. W., Jan 1 1980, In : American Journal of Hospital Pharmacy. 37, 4, p. 492-496 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Clinical pharmacy. Glutethimide overdose. Clinical and kinetic observations of glutethimide and a metabolite

Rotschafer, J. C., Foley, C. & Zaske, D., Jan 1 1980, In : Minnesota medicine. 63, 2, p. 145-147 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comparison of a radioimmunoassay and a microbiological assay for measurement of serum vancomycin concentrations

Crossley, K. B., Rotschafer, J. C., Chern, M. M., Mead, K. E. & Zaske, D. E., Jan 1 1980, In : Antimicrobial agents and chemotherapy. 17, 4, p. 654-657 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Neurologic prognosis after cardiopulmonary arrest: III. Seizure activity

Snyder, B. D., Hauser, W. A., Loewenson, R. B., Leppik, I. E., Ramirez-Lassepas, M. & Gumnit, R. J., Dec 1980, In : Neurology. 30, 12, p. 1292-1297 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Neurologic prognosis after cardiopulmonary arrest: II. level of consciousness

Synder, B. D., Loewenson, R. B., Gumnit, R. J., Hauser, W. A., Leppik, I. E. & Ramirez-Lassepas, M., Jan 1980, In : Neurology. 30, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Phenytoin and Formation of T Lymphocyte Rosettes

Neilan, B. A. & Leppik, I. E., Sep 1980, In : Archives of Neurology. 37, 9, p. 580-581 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Potentiation of Warfarin Anticoagulation by Sulfisoxazole

Sioris, L. J., Weibert, R. T. & Pentel, P. R., Apr 1980, In : Archives of Internal Medicine. 140, 4, p. 546-547 2 p.

Research output: Contribution to journalArticle

17 Scopus citations

Reduced seizure control due to spoiled phenytoin capsules

Cloyd, J. C., Gumnit, R. J. & Lesar, T. S., Feb 1980, In : Annals of Neurology. 7, 2, p. 191-193 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Status Epilepticus: The Role of Intravenous Phenytoin

Cloyd, J. C., Gumnit, R. J. & Mclain, L. W., Sep 26 1980, In : JAMA: The Journal of the American Medical Association. 244, 13, p. 1479-1481 3 p.

Research output: Contribution to journalArticle

20 Scopus citations
1981

Acute Phenytoin and Primidone Intoxication A Pharmacokinetic Analysis

MATZKE, GARY. R., CLOYD, JAMES. C. & SAWCHUK, RONALD. J., Jan 1 1981, In : The Journal of Clinical Pharmacology. 21, 2-3, p. 92-99 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Altered phenytoin clearance during febrile illnesses

Leppik, I. A., Fisher, J., Kriel, R. & Sawchuck, R., Jan 1 1981, In : Neurology. 31, 4 II, 1 p.

Research output: Contribution to journalArticle

Bioavailability of reetally administered valproic acid syrup

Cloyd, J. C. & Kriel, R. L., Oct 1981, In : Neurology. 31, 10, p. 1348-1352 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Data banks and clinical trials: From adversaries to complementary tools

Kunitz, S. C., Gross, C. & Heyman, A., May 1981, In : Controlled Clinical Trials. 2, 1, p. 68-69 2 p.

Research output: Contribution to journalArticle

Diluting diazepam injection

Cloyd, J. C., Jan 1 1981, In : American Journal of Hospital Pharmacy. 38, 1, 1 p.

Research output: Contribution to journalArticle

Effect of concomitant antiepileptic therapy on valproic acid pharmacokinetics

Fischer, J. H., Cloyd, J. C. & Kriel, R. L., Jan 1 1981, In : Epilepsia. 22, 2, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Incidence of late arrhythmias following tricyclic antidepressant overdose

Pentel, P. & Sioris, L. J., Jan 1 1981, In : Clinical Toxicology. 18, 5, p. 543-548 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Moxalactam therapy for a wide spectrum of bacterial infections in adults

Tofte, R. W., Rotschafer, J. C., Solliday, J. & Crossley, K. B., Jan 1 1981, In : Antimicrobial agents and chemotherapy. 19, 5, p. 740-744 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Neurologic prognosis after cardiopulmonary arrest: IV. Brainstem reflexes

Snyder, B. D., Gumnit, R. J., Leppik, I. E., Ramirez-Lassepas, M., Loewenson, R. B. & Ramirez-Lassepas, M., Sep 1981, In : Neurology. 31, 9, p. 1092-1097 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phenytoin binding in patients undergoing renal transplantation

Kang, H., Leppik, I. E. & Canafex, D., Jan 1 1981, In : Neurology. 31, 4 II, 1 p.

Research output: Contribution to journalArticle

Primidone kinetics: Effects of concurrent drugs and duration of therapy

Cloyd, J. C., Miller, K. W. & Leppik, I. E., Mar 1981, In : Clinical pharmacology and therapeutics. 29, 3, p. 402-407 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recent studies of the pharmacokinetics of vancomycin

Rotschafer, J., Mead, K. & Crossley, K., Jan 1 1981, In : Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A. 251, Suppl. 10, p. 773-776 4 p.

Research output: Contribution to journalArticle

Staphylococcus aureus Infection of Dialysis shunt: Absence of Synergy with Vancomycin and Rifampin

Tofte, R. W., Solliday, J., Rotschafer, J. C. & Crossley, K. B., May 1981, In : Southern Medical Journal. 74, 5, p. 612-615 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1982

Assay specificity for biologically active gentamicin in serum

Lackner, T. E., Rotschafer, J. C., Crossley, K. & LaBrosse, K., Jan 1 1982, In : American Journal of Hospital Pharmacy. 39, 4, p. 647-648 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cefaclor pharmacokinetic parameters: Serum concentrations determined by a new high-performance liquid chromatographic technique

Rotschafer, J. C., Crossley, K. B., Lesar, T. S., Zaske, D. & Miller, K., Jan 1 1982, In : Unknown Journal. 21, 1, p. 170-172 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Comparison of radioimmunoassay and enzyme immunoassay methods in determining gentamicin pharmacokinetic parameters and dosages

Rotschafer, J. C., Morlock, C., Strand, L. & Crossley, K., Jan 1 1982, In : Antimicrobial agents and chemotherapy. 22, 4, p. 648-651 4 p.

Research output: Contribution to journalArticle

10 Scopus citations