Experimental and Clinical Pharmacology

Research Output

2018

Plasma lipoproteome in Alzheimer's disease: A proof-of-concept study

Li, D., Huang, F., Zhao, Y., Villata, P. W., Griffin, T. J., Zhang, L., Li, L. & Yu, F., Sep 20 2018, In : Clinical Proteomics. 15, 1, 31.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls

Shafee, R., Nanda, P., Padmanabhan, J. L., Tandon, N., Alliey-Rodriguez, N., Kalapurakkel, S., Weiner, D. J., Gur, R. E., Keefe, R. S. E., Hill, S. K., Bishop, J. R., Clementz, B. A., Tamminga, C. A., Gershon, E. S., Pearlson, G. D., Keshavan, M. S., Sweeney, J. A., McCarroll, S. A. & Robinson, E. B., Dec 1 2018, In : Translational psychiatry. 8, 1, 78.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins

Baruffaldi, F., Kelcher, A. H., Laudenbach, M., Gradinati, V., Limkar, A., Roslawski, M., Birnbaum, A. K., Lees, A., Hassler, C., Runyon, S. & Pravetoni, M., Nov 5 2018, In : Molecular pharmaceutics. 15, 11, p. 4947-4962 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Open Access
28 Scopus citations

Rescue therapies for seizure emergencies: New modes of administration

Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 2018, In : Epilepsia. 59, p. 207-215 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Sensitive Determination of Fentanyl in Low-Volume Serum Samples by LC-MS/MS

Swaminathan, S. K., Fisher, J. & Kandimalla, K. K., Oct 1 2018, In : AAPS PharmSciTech. 19, 7, p. 2812-2817 6 p.

Research output: Contribution to journalArticle

Serum sodium response to hypertonic saline infusion therapy in traumatic brain injury

Chapman, S. A., Irwin, E. D., Thunselle, M., Ronk, A., Reicks, P., Curran, B., Rangarajan, K., Tam, H. & Beilman, G. J., Feb 2018, In : Journal of Clinical Neuroscience. 48, p. 147-152 6 p.

Research output: Contribution to journalArticle

Status epilepticus in the elderly

Leppik, I. E., Oct 2018, In : Epilepsia. 59, p. 140-143 4 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density

Hottman, D., Cheng, S., Gram, A., LeBlanc, K., Yuan, L. L. & Li, L., Mar 1 2018, In : Neuroscience. 373, p. 207-217 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination

Scheibner, A., Remmel, R. P., Schladt, D., Oetting, W. S., Guan, W., Wu, B., Dorr, C., Israni, A. & Jacobson, P. A., Jul 2018, In : Pharmacotherapy. 38, 7, p. e46-e52

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
6 Scopus citations

The authors reply

Chlan, L. L., Heiderscheit, A. L., Skaar, D. J. & Neidecker, M. V., Nov 1 2018, In : Critical care medicine. 46, 11, p. e1085-e1086

Research output: Contribution to journalComment/debate

Open Access

Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses

Omura, S., Kawai, E., Sato, F., Martinez, N. E., Minagar, A., Al-Kofahi, M., Yun, J. W., Cvek, U., Trutschl, M., Alexander, J. S. & Tsunoda, I., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue

Nicol, M. R., Brewers, L. M., Kashuba, A. D. M. & Sykes, C., Jan 2 2018, In : AIDS. 32, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

Wu, J. F., Muthusamy, A., Al-Ghalith, G. A., Knights, D., Guo, B., Wu, B., Remmel, R. P., Schladt, D. P., Alegre, M. L., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Dec 2018, In : Clinical Transplantation. 32, 12, e13436.

Research output: Contribution to journalArticle

4 Scopus citations

Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs.

Jacobson, P., Schladt, D., Guan, W., van Setten, J., Remmel, R., Wu, B., Dorr, C., Keating, B., Ikle, D. & Mannon, R., 2018, p. 793. 1 p.

Research output: Contribution to conferencePaper

2017

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Chen, A., Smith, K. P., Whitfield, B. A., Zucchi, P. C., Lasco, T. M., Bias, T. E., Kirby, J. E. & Hirsch, E. B., Aug 2017, In : Diagnostic Microbiology and Infectious Disease. 88, 4, p. 365-367 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Adenosine Triphosphate Quantification Correlates Poorly with Microbial Contamination of Duodenoscopes

Olafsdottir, L. B., Wright, S. B., Smithey, A., Heroux, R., Hirsch, E. B., Chen, A., Lane, B., Sawhney, M. S. & Snyder, G. M., Jun 1 2017, In : Infection Control and Hospital Epidemiology. 38, 6, p. 678-684 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
7 Scopus citations

Analysis of falls in patients with epilepsy enrolled in the perampanel phase III randomized double-blind studies

Leppik, I. E., Yang, H., Williams, B., Zhou, S., Fain, R., Patten, A., Bibbiani, F. & Laurenza, A., Jan 1 2017, In : Epilepsia. 58, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Anatomy and roles of lymphatics in inflammatory diseases

Al-Kofahi, M., Yun, J. W., Minagar, A. & Alexander, J. S., Aug 2017, In : Clinical and Experimental Neuroimmunology. 8, 3, p. 199-214 16 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Antiseizure, antidepressant, and antipsychotic medication prescribing in elderly nursing home residents

Bathena, S. P. R., Leppik, I. E., Kanner, A. M. & Birnbaum, A. K., Apr 1 2017, In : Epilepsy and Behavior. 69, p. 116-120 5 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Antiseizure drug therapy in children

Conway, J. M., Leppik, I. E. & Birnbaum, A. K., May 11 2017, Swaiman's Pediatric Neurology: Principles and Practice: Sixth Edition. Elsevier Inc., p. 600-611 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 2017, In : PM and R. 9, 8, p. 743-750 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
3 Scopus citations

Assessment of Fosfomycin for Complicated or Multidrug-Resistant Urinary Tract Infections: Patient Characteristics and Outcomes

Giancola, S. E., Mahoney, M. V., Hogan, M. D., Raux, B. R., McCoy, C. & Hirsch, E. B., Jan 1 2017, In : Chemotherapy. p. 100-104 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

Hicks, J. K., Sangkuhl, K., Swen, J. J., Ellingrod, V. L., Müller, D. J., Shimoda, K., Bishop, J. R., Kharasch, E. D., Skaar, T. C., Gaedigk, A., Dunnenberger, H. M., Klein, T. E., Caudle, K. E. & Stingl, J. C., Jul 1 2017, In : Clinical pharmacology and therapeutics. 102, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Cognitive burden of anticholinergic medications in psychotic disorders

Eum, S., Hill, S. K., Rubin, L. H., Carnahan, R. M., Reilly, J. L., Ivleva, E. I., Keedy, S. K., Tamminga, C. A., Pearlson, G. D., Clementz, B. A., Gershon, E. S., Keshavan, M. S., Keefe, R. S. E., Sweeney, J. A. & Bishop, J. R., Dec 2017, In : Schizophrenia Research. 190, p. 129-135 7 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Collaborative Counseling Considerations for Pharmacogenomic Tests

Zierhut, H. A., Campbell, C. A., Mitchell, A. G., Lemke, A. A., Mills, R. & Bishop, J. R., Sep 2017, In : Pharmacotherapy. 37, 9, p. 990-999 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity

Spaulding, A., Takrouri, K., Mahalingam, P., Cleary, D. C., Cooper, H. D., Zucchi, P., Tear, W., Koleva, B., Beuning, P. J., Hirsch, E. B. & Aggen, J. B., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5310-5321 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites

Flora, D. R., Rettie, A. E., Brundage, R. C. & Tracy, T. S., Jan 1 2017, In : Journal of Clinical Pharmacology. 57, 3, p. 382-393 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Discovering drugs to overcome chemoresistance in ovarian cancers based on the cancer genome atlas tumor transcriptome profile

Wang, F., Chang, J. T. H., Zhang, Z., Morrison, G., Nath, A., Bhutra, S. & Huang, R. S., Jan 1 2017, In : Oncotarget. 8, 70, p. 115102-115113 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies

Geeleher, P., Zhang, Z., Wang, F., Gruener, R. F., Nath, A., Morrison, G., Bhutra, S., Grossman, R. L. & Huang, R. S., Oct 2017, In : Genome Research. 27, 10, p. 1743-1751 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Duodenoscope hang time does not correlate with risk of bacterial contamination

Heroux, R., Sheppard, M., Wright, S. B., Sawhney, M., Hirsch, E. B., Kalaidjian, R. & Snyder, G. M., Apr 1 2017, In : American journal of infection control. 45, 4, p. 360-364 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Engaging Hmong adults in genomic and pharmacogenomic research: Toward reducing health disparities in genomic knowledge using a community-based participatory research approach

Culhane-Pera, K. A., Straka, R. J., Moua, M. K., Roman, Y., Vue, P., Xiaaj, K., Lo, M. X. & Lor, M., Apr 1 2017, In : Journal of Community Genetics. 8, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Epidermal growth factor receptor signaling enhances the proinflammatory effects of staphylococcus aureus gamma-toxin on the mucosa

Gillman, A. N., Breshears, L. M., Kistler, C. K., Finnegan, P. M., Torres, V. J., Schlievert, P. M. & Peterson, M. L., Jul 1 2017, In : Toxins. 9, 7, 202.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Exploring the link between the germline and somatic genome in cancer

Geeleher, P. & Huang, R. S., Apr 2017, In : Cancer discovery. 7, 4, p. 354-355 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy

Conway, J. M., Eberly, L. E., Collins, J. F., Macias, F. M., Ramsay, R. E., Leppik, I. E. & Birnbaum, A. K., Oct 2017, In : Pharmacotherapy. 37, 10, p. 1197-1203 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study

Lencer, R., Mills, L. J., Alliey-Rodriguez, N., Shafee, R., Lee, A. M., Reilly, J. L., Sprenger, A., McDowell, J. E., McCarroll, S. A., Keshavan, M. S., Pearlson, G. D., Tamminga, C. A., Clementz, B. A., Gershon, E. S., Sweeney, J. A. & Bishop, J. R., Oct 24 2017, In : Translational psychiatry. 7, 10, p. e1249

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

Sanghavi, K., Brundage, R. C., Miller, M. B., Schladt, D. P., Israni, A. K., Guan, W., Oetting, W. S., Mannon, R. B., Remmel, R. P., Matas, A. J. & Jacobson, P. A., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice

Cheng, S., Wani, W. Y., Hottman, D. A., Jeong, A., Cao, D., LeBlanc, K. J., Saftig, P., Zhang, J. & Li, L., Jul 1 2017, In : Journal of Neurochemistry. 142, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Implementing pharmacogenomics in modern health care: The 2017 scientific meeting of the Human Genome Variation Society

Lanting, P. & Oetting, W. S., Nov 2017, In : Human mutation. 38, 11, p. 1606-1610 5 p.

Research output: Contribution to journalArticle

Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage

Yanik, M. V., Irvin, M. R., Beasley, T. M., Jacobson, P. A., Julian, B. A. & Limdi, N. A., Nov 2017, In : Pharmacotherapy. 37, 11, p. 1366-1373 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Institutional Profile: Pharmacogenomic research in R Stephanie Huang Laboratory

Geeleher, P., Nath, A. & Huang, R. S., Apr 2017, In : Pharmacogenomics. 18, 6, p. 519-522 4 p.

Research output: Contribution to journalArticle

Integrated microfluidic platform for rapid antimicrobial susceptibility testing and bacterial growth analysis using bead-based biosensor via fluorescence imaging

Sabhachandani, P., Sarkar, S., Zucchi, P. C., Whitfield, B. A., Kirby, J. E., Hirsch, E. B. & Konry, T., Dec 1 2017, In : Microchimica Acta. 184, 12, p. 4619-4628 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Leaves imitate trees: Minnesota Hmong concepts of heredity and applications to genomics research

Culhane-Pera, K. A., Moua, M. K., Vue, P., Xiaaj, K., Lo, M. X. & Straka, R. J., Jan 1 2017, In : Journal of Community Genetics. 8, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Modeling Enterohepatic Circulation

Okour, M. & Brundage, R. C., Oct 1 2017, In : Current Pharmacology Reports. 3, 5, p. 301-313 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Nasal methicillin-resistant Staphylococcus aureus screening in patients with pneumonia: A powerful antimicrobial stewardship tool

Smith, E. A., Gold, H. S., Mahoney, M. V., Hirsch, E. B., Giancola, S. E., Snyder, G. M., Marks, G., Tran, H., Hirai-Yang, A. & McCoy, C., Nov 1 2017, In : American journal of infection control. 45, 11, p. 1295-1296 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Naturally Occurring Epilepsy and Status Epilepticus in Dogs

Potschka, H., Patterson, E. N. & Leppik, I. E., Jan 1 2017, Models of Seizures and Epilepsy: Second Edition. Elsevier Inc., p. 387-398 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter