Projects per year
Organization profile
Organization profile
Chronic illnesses, such as diabetes, cancer, cardiovascular disease, and asthma, afflict large numbers of people in the United States and other countries. These diseases are complex, and often include components of inflammation or pain.
Faculty in the Chronic Disease Bioscience research cluster are investigating the biological underpinnings of persistent or recurring diseases in animal cell lines and disease models. Their research uncovers roles for the genes, molecules, and cells involved in the initiation and progression of chronic disease states.
This information is then used to develop innovative therapeutic strategies to alleviate diseases of frequent recurrence or long duration in animals and people.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Profiles
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David R Brown
- Veterinary and Biomedical Sciences - Professor, Chair
- Chronic Disease Biology
Person: Faculty, Executive, Administrative, and Managerial Staff
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John P Collister
- Veterinary and Biomedical Sciences - Associate Professor
- Chronic Disease Biology
Person: Faculty
Projects
- 25 Finished
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Improving vascular function and bacterial clearance duri
Walcheck, B., Arndt, P. G., Rao, S. & Seelig, D.
National Heart, Lung, and Blood Institute
4/1/16 → 3/31/21
Project: Research project
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Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation
Choi, S. R., Beitz, A. J. & Lee, J. H., Oct 2019, In: Biomedicine and Pharmacotherapy. 118, 109299.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
nNOS-PSD95 interactions activate the PKC-ε isoform leading to increased GluN1 phosphorylation and the development of neuropathic mechanical allodynia in mice
Choi, S. R., Han, H. J., Beitz, A. J. & Lee, J. H., Jun 11 2019, In: Neuroscience Letters. 703, p. 156-161 6 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Spinal cytochrome P450c17 plays a key role in the development of neuropathic mechanical allodynia: Involvement of astrocyte sigma-1 receptors
Choi, S. R., Roh, D. H., Yoon, S. Y., Choi, H. S., Kang, S. Y., Han, H. J., Beitz, A. J. & Lee, J. H., May 1 2019, In: Neuropharmacology. 149, p. 169-180 12 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations