Organization profile

Organization profile

Chronic illnesses, such as diabetes, cancer, cardiovascular disease, and asthma, afflict large numbers of people in the United States and other countries. These diseases are complex, and often include components of inflammation or pain.
Faculty in the Chronic Disease Bioscience research cluster are investigating the biological underpinnings of persistent or recurring diseases in animal cell lines and disease models. Their research uncovers roles for the genes, molecules, and cells involved in the initiation and progression of chronic disease states.
This information is then used to develop innovative therapeutic strategies to alleviate diseases of frequent recurrence or long duration in animals and people.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neurons Medicine & Life Sciences
Hyperalgesia Medicine & Life Sciences
Swine Medicine & Life Sciences
Periaqueductal Gray Medicine & Life Sciences
Pain Medicine & Life Sciences
Injections Medicine & Life Sciences
Bee Venoms Medicine & Life Sciences
Spinal Cord Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1996 2022

Chronic Pancreatitis
Trypsin
Inflammation

Research Output 1976 2017

A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity

Yoon, S. Y., Kwon, S. G., Kim, Y. H., Yeo, J. H., Ko, H. G., Roh, D. H., Kaang, B. K., Beitz, A. J., Lee, J. H. & Oh, S. B. 2017 In : Molecular Pain. 13

Research output: Research - peer-reviewArticle

N-Methylaspartate
Hypersensitivity
Pain
Proteins
N-Methyl-D-Aspartate Receptors
2 Citations

The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

Choi, H. S., Roh, D. H., Yoon, S. Y., Kwon, S. G., Choi, S. R., Kang, S. Y., Moon, J. Y., Han, H. J., Kim, H. W., Beitz, A. J. & Lee, J. H. Jan 1 2017 In : Experimental Neurology. 287, p. 1-13 13 p.

Research output: Research - peer-reviewArticle

Connexin 43
Hyperalgesia
Interleukin-1beta
Astrocytes
Pain
3 Citations

Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice

Choi, S. R., Roh, D. H., Yoon, S. Y., Kwon, S. G., Choi, H. S., Han, H. J., Beitz, A. J. & Lee, J. H. Dec 1 2016 In : Neuropharmacology. 111, p. 34-46 13 p.

Research output: Research - peer-reviewArticle

Connexin 43
Hyperalgesia
Astrocytes
Spinal Cord
sigma-1 receptor