Organization profile

Organization profile

Chronic illnesses, such as diabetes, cancer, cardiovascular disease, and asthma, afflict large numbers of people in the United States and other countries. These diseases are complex, and often include components of inflammation or pain.
Faculty in the Chronic Disease Bioscience research cluster are investigating the biological underpinnings of persistent or recurring diseases in animal cell lines and disease models. Their research uncovers roles for the genes, molecules, and cells involved in the initiation and progression of chronic disease states.
This information is then used to develop innovative therapeutic strategies to alleviate diseases of frequent recurrence or long duration in animals and people.

Fingerprint Dive into the research topics where Chronic Disease Biology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Hyperalgesia Medicine & Life Sciences
Neurons Medicine & Life Sciences
Periaqueductal Gray Medicine & Life Sciences
Bee Venoms Medicine & Life Sciences
Swine Medicine & Life Sciences
Jejunum Medicine & Life Sciences
Ion Transport Medicine & Life Sciences
Spinal Trigeminal Nucleus Medicine & Life Sciences

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Projects 1996 2022

Natural Killer Cells
Neoplasms

Research Output 1976 2019

nNOS-PSD95 interactions activate the PKC-ε isoform leading to increased GluN1 phosphorylation and the development of neuropathic mechanical allodynia in mice

Choi, S. R., Han, H. J., Beitz, A. J. & Lee, J. H., Jun 11 2019, In : Neuroscience Letters. 703, p. 156-161 6 p.

Research output: Contribution to journalArticle

Post-Synaptic Density
Nitric Oxide Synthase Type I
Hyperalgesia
Protein Isoforms
Phosphorylation
Open Access
Hyperalgesia
Neuralgia
Cytochromes
Interleukin-1
Astrocytes
9 Citations (Scopus)

Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain

Choi, S. R., Moon, J. Y., Roh, D. H., Yoon, S. Y., Kwon, S. G., Choi, H. S., Kang, S. Y., Han, H. J., Beitz, A. J. & Lee, J. H., Apr 1 2017, In : Journal of Pain. 18, 4, p. 415-427 13 p.

Research output: Contribution to journalArticle

Hyperalgesia
Neuralgia
Serine
Protein Kinase C
Phosphorylation