Organization profile

Organization profile

Chronic illnesses, such as diabetes, cancer, cardiovascular disease, and asthma, afflict large numbers of people in the United States and other countries. These diseases are complex, and often include components of inflammation or pain.
Faculty in the Chronic Disease Bioscience research cluster are investigating the biological underpinnings of persistent or recurring diseases in animal cell lines and disease models. Their research uncovers roles for the genes, molecules, and cells involved in the initiation and progression of chronic disease states.
This information is then used to develop innovative therapeutic strategies to alleviate diseases of frequent recurrence or long duration in animals and people.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Hyperalgesia Medicine & Life Sciences
Neurons Medicine & Life Sciences
Periaqueductal Gray Medicine & Life Sciences
Bee Venoms Medicine & Life Sciences
Swine Medicine & Life Sciences
Jejunum Medicine & Life Sciences
Ion Transport Medicine & Life Sciences
Spinal Trigeminal Nucleus Medicine & Life Sciences

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Projects 1996 2022

Research Output 1976 2017

5 Citations

The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

Choi, H. S., Roh, D. H., Yoon, S. Y., Kwon, S. G., Choi, S. R., Kang, S. Y., Moon, J. Y., Han, H. J., Kim, H. W., Beitz, A. J. & Lee, J. H. Jan 1 2017 In : Experimental Neurology. 287, p. 1-13 13 p.

Research output: Contribution to journalArticle

Connexin 43
Hyperalgesia
Interleukin-1beta
Astrocytes
Carrageenan
7 Citations

Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice

Choi, S. R., Roh, D. H., Yoon, S. Y., Kwon, S. G., Choi, H. S., Han, H. J., Beitz, A. J. & Lee, J. H. Dec 1 2016 In : Neuropharmacology. 111, p. 34-46 13 p.

Research output: Contribution to journalArticle

Connexin 43
Hyperalgesia
Astrocytes
Spinal Cord
Spinal Cord Injuries

Estimating local biodiversity change: a critique of papers claiming no net loss of local diversitY

Gonzalez, A. H., Cardinale, B. J., Allington, G. R. H., Byrnes, J., Endsley, K. A., Brown, D. G., Hooper, D. U., Isbell, F., Loreau, M. & O'Connor, M. I. 2016 In : Ecology. 97, 8, p. 1949-1960 12 p.

Research output: Contribution to journalArticle