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2020

Enhanced Molecular Tension Sensor Based on Bioluminescence Resonance Energy Transfer (BRET)

Aird, E. J., Tompkins, K. J., Ramirez, M. P. & Gordon, W. R., Jan 24 2020, In : ACS Sensors. 5, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution

Yang, T., Yao, Y., Wang, X., Li, Y., Si, Y., Li, X., Ayala, G. J., Wang, Y., Mayo, K. H., Tai, G., Zhou, Y. & Su, J., Jan 28 2020, In : Glycobiology. 30, 2, p. 120-129 10 p.

Research output: Contribution to journalArticle

Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

Larsen, E. K., Weber, D. K., Wang, S., Gopinath, T., Blackwell, D. J., Dalton, M. P., Robia, S. L., Gao, J. & Veglia, G., Jan 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 1, 183034.

Research output: Contribution to journalArticle

Open Access

Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Lindsay, A., Baumann, C. W., Rebbeck, R. T., Yuen, S. L., Southern, W. M., Hodges, J. S., Cornea, R. L., Thomas, D. D., Ervasti, J. M. & Lowe, D. A., Feb 1 2020, In : Skeletal Muscle. 10, 1, 3.

Research output: Contribution to journalArticle

Open Access
Open Access

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

McCarthy, M. R., Savich, Y., Cornea, R. L. & Thomas, D. D., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1090-1100 11 p.

Research output: Contribution to journalArticle

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, R. T., Singh, D. P., Janicek, K. A., Bers, D. M., Thomas, D. D., Launikonis, B. S. & Cornea, R. L., Dec 1 2020, In : Scientific reports. 10, 1, 1791.

Research output: Contribution to journalArticle

Open Access

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs

Stroik, D. R., Ceholski, D. K., Bidwell, P. A., Mleczko, J., Thanel, P. F., Kamdar, F., Autry, J. M., Cornea, R. L. & Thomas, D. D., Jan 2020, In : Journal of Molecular and Cellular Cardiology. 138, p. 59-65 7 p.

Research output: Contribution to journalArticle

2019

A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

Wook Park, S., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., Lin, Y. L., Kagechika, H., Mayo, K. H. & Wei, L. N., Dec 1 2019, In : Scientific reports. 9, 1, 10929.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins

Hall, J. W., Lima, B. P., Herbomel, G. G., Gopinath, T., McDonald, L. A., Shyne, M. T., Lee, J. K., Kreth, J., Ross, K. F., Veglia, G. & Herzberg, M. C., May 7 2019, In : Science signaling. 12, 580, eaas9941.

Research output: Contribution to journalArticle

1 Scopus citations

A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Duggirala, N. K., Li, J., Krishna Kumar, N. S., Tata, G. & Suryanarayanan, R., Jan 1 2019, In : Chemical Communications. 55, 39, p. 5551-5554 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label

Binder, B. P., Thompson, A. R. & Thomas, D. D., Jul 23 2019, In : Biophysical journal. 117, 2, p. 319-330 12 p.

Research output: Contribution to journalArticle

A toolkit for studying cell surface shedding of diverse transmembrane receptors

Hayward, A. N., Aird, E. J. & Gordon, W. R., Jun 2019, In : eLife. 8, e46983.

Research output: Contribution to journalArticle

Open Access

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Walweel, K., Gomez-Hurtado, N., Rebbeck, R. T., Oo, Y. W., Beard, N. A., Molenaar, P., dos Remedios, C., van Helden, D. F., Cornea, R. L., Knollmann, B. C. & Laver, D. R., May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 96-106 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Circulating tumor biomarkers in meningiomas reveal a signature of equilibrium between tumor growth and immune modulation

Erkan, E. P., Ströbel, T., Dorfer, C., Sonntagbauer, M., Weinhäusel, A., Saydam, N. & Saydam, O., Sep 1 2019, In : Frontiers in Oncology. 9, SEP, 1031.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis

Valberg, S. J., Soave, K., Williams, Z. J., Perumbakkam, S., Schott, M., Finno, C. J., Petersen, J. L., Fenger, C., Autry, J. M. & Thomas, D. D., Mar 1 2019, In : Journal of veterinary internal medicine. 33, 2, p. 933-941 9 p.

Research output: Contribution to journalArticle

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Crystal structure of the Wheat dwarf virus Rep domain Everett Blake A.

Everett, B. A., Litzau, L. A., Tompkins, K., Shi, K., Nelson, A., Aihara, H., Evans, R. L. E. & Gordon, W. R., Dec 1 2019, In : Acta Crystallographica Section F: Structural Biology Communications. 75, p. 744-749 6 p.

Research output: Contribution to journalArticle

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Walker, C., Wang, Y., Olivieri, C., Karamafrooz, A., Casby, J., Bathon, K., Calebiro, D., Gao, J., Bernlohr, D. A., Taylor, S. S. & Veglia, G., Aug 28 2019, In : Science advances. 5, 8, eaaw9298.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway

Koehn, E. M., Latham, J. A., Armand, T., Evans, R. L., Tu, X., Wilmot, C. M., Iavarone, A. T. & Klinman, J. P., Mar 13 2019, In : Journal of the American Chemical Society. 141, 10, p. 4398-4405 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dynamic allostery-based molecular workings of kinase:peptide complexes

Ahuja, L. G., Aoto, P. C., Kornev, A. P., Veglia, G. & Taylor, S. S., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 30, p. 15052-15061 10 p.

Research output: Contribution to journalArticle

Open Access

Galectin-3 binds selectively to the terminal, non-reducing end of β(1→4)-galactans, with overall affinity increasing with chain length

Miller, M. C., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jan 1 2019, In : Glycobiology. 29, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

Wang, Y., V.S, M., Kim, J., Li, G., Ahuja, L. G., Aoto, P., Taylor, S. S. & Veglia, G., Dec 1 2019, In : Nature communications. 10, 1, 799.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Webber, B. R., Lonetree, C. L., Kluesner, M. G., Johnson, M. J., Pomeroy, E. J., Diers, M. D., Lahr, W. S., Draper, G. M., Slipek, N. J., Smeester, B. S., Lovendahl, K. N., McElroy, A. N., Gordon, W. R., Osborn, M. J. & Moriarity, B. S., Dec 1 2019, In : Nature communications. 10, 1, 5222.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hybridization of TEDOR and NCX MAS solid-state NMR experiments for simultaneous acquisition of heteronuclear correlation spectra and distance measurements

Tata, G., Wang, S., Lee, J., Aihara, H. & Veglia, G., Apr 15 2019, In : Journal of Biomolecular Nmr. 73, 3-4, p. 141-153 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hybrid ligands with calixarene and thiodigalactoside groups: Galectin binding and cytotoxicity

Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H. & Pieters, R. J., Aug 21 2019, In : Organic Chemistry Frontiers. 6, 16, p. 2981-2990 10 p.

Research output: Contribution to journalArticle

Improving the quality of oriented membrane protein spectra using heat-compensated separated local field experiments

Wang, S., Gopinath, T. & Veglia, G., Nov 1 2019, In : Journal of biomolecular NMR. 73, 10-11, p. 617-624 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

Savich, Y., Binder, B. P., Thompson, A. R. & Thomas, D. D., Aug 5 2019, In : Journal of General Physiology. 151, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: Evidence for noncanonical interactions with the lectin's CRD β-sandwich F-face

Zhang, Z., Miller, M. C., Xu, X., Song, C., Zhang, F., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jul 19 2019, In : Glycobiology. 29, 8, p. 608-618 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C. C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

2 Scopus citations

Programmable Assembly of Adeno-Associated Virus-Antibody Composites for Receptor-Mediated Gene Delivery

Zdechlik, A. C., He, Y., Aird, E. J., Gordon, W. R. & Schmidt, D., Jan 1 2019, (Accepted/In press) In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

Salicylate 5-Hydroxylase: Intermediates in Aromatic Hydroxylation by a Rieske Monooxygenase

Rogers, M. S. & Lipscomb, J. D., Dec 31 2019, In : Biochemistry. 58, 52, p. 5305-5319 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Separating graphene quantum dots by lateral size through gel column chromatography

Wu, W., Cao, J., Zhong, M., Wu, H., Zhang, F., Zhang, J. & Guo, S., Jan 1 2019, In : RSC Advances. 9, 33, p. 18898-18901 4 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Soluble methane monooxygenase

Banerjee, R., Jones, J. C. & Lipscomb, J. D., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 409-431 23 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure and Function of Tryptophan-Tyrosine Dyads in Biomimetic β Hairpins

McCaslin, T. G., Pagba, C. V., Chi, S. H., Hwang, H. J., Gumbart, J. C., Perry, J. W., Olivieri, C., Porcelli, F., Veglia, G., Guo, Z., McDaniel, M. & Barry, B. A., Apr 4 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2780-2791 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

Yang, N., Liu, S., Qin, T., Liu, X., Watanabe, N., Mayo, K. H., Li, J. & Li, X., Nov 21 2019, In : Cell Communication and Signaling. 17, 1, 153.

Research output: Contribution to journalArticle

Open Access

T2* weighted Deconvolution of NMR Spectra: Application to 2D Homonuclear MAS Solid-State NMR of Membrane Proteins

Manu, V. S., Gopinath, T., Wang, S. & Veglia, G., Dec 1 2019, In : Scientific reports. 9, 1, 8225.

Research output: Contribution to journalArticle

Open Access

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Lo, C. H., Lim, C. K. W., Ding, Z., Wickramasinghe, S. P., Braun, A. R., Ashe, K. H., Rhoades, E., Thomas, D. D. & Sachs, J. N., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Johnson, C. N., Pattanayek, R., Potet, F., Rebbeck, R. T., Blackwell, D. J., Nikolaienko, R., Sequeira, V., Le Meur, R., Radwański, P. B., Davis, J. P., Zima, A. V., Cornea, R. L., Damo, S. M., Györke, S., George, A. L. & Knollmann, B. C., Sep 2019, In : Cell Calcium. 82, 102063.

Research output: Contribution to journalArticle

1 Scopus citations

Trajectory-Based Simulation of EPR Spectra: Models of Rotational Motion for Spin Labels on Proteins

Martin, P. D., Svensson, B., Thomas, D. D. & Stoll, S., Dec 5 2019, In : Journal of Physical Chemistry B. 123, 48, p. 10131-10141 11 p.

Research output: Contribution to journalArticle

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Batiste, S. M., Blackwell, D. J., Kim, K., Kryshtal, D. O., Gomez-Hurtado, N., Rebbeck, R. T., Cornea, R. L., Johnston, J. N. & Knollmann, B. C., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4810-4815 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex

Gerlits, O., Weiss, K. L., Blakeley, M. P., Veglia, G., Taylor, S. S. & Kovalevsky, A., Jan 1 2019, In : Science advances. 5, 3, eaav0482.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Adhesion/growth-regulatory galectins tested in combination: Evidence for formation of hybrids as heterodimers

Miller, M. C., Ludwig, A. K., Wichapong, K., Kaltner, H., Kopitz, J., Gabius, H. J. & Mayo, K. H., Mar 15 2018, In : Biochemical Journal. 475, 5, p. 1003-1018 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

A dynamic mechanism for allosteric activation of aurora kinase a by activation loop phosphorylation

Ruff, E. F., Muretta, J. M., Thompson, A. R., Lake, E. W., Cyphers, S., Albanese, S. K., Hanson, S. M., Behr, J. M., Thomas, D. D., Chodera, J. D. & Levinson, N. M., Feb 21 2018, In : eLife. 7, e32766.

Research output: Contribution to journalArticle

17 Scopus citations

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice

Phung, L. A., Karvinen, S. M., Colson, B. A., Thomas, D. D. & Lowe, D. A., Sep 2018, In : PloS one. 13, 9, e0199062.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ALARM NMR for HTS triage and chemical probe validation

Dahlin, J. L., Cuellar, M., Singh, G., Nelson, K. M., Strasser, J., Rappe, T., Xia, Y., Veglia, G. & Walters, M. A., Mar 1 2018, In : Current protocols in chemical biology. 10, 1, p. 91-117 27 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature

Huijbers, E. J. M., van Beijnum, J. R., Lê, C. T., Langman, S., Nowak-Sliwinska, P., Mayo, K. H. & Griffioen, A. W., May 17 2018, In : Vaccine. 36, 21, p. 3054-3060 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations