Research Output

2020

A hallmark of phospholamban functional divergence is located in the N-terminal phosphorylation domain

Fernández-de Gortari, E., Aguayo-Ortiz, R., Autry, J. M. & Michel Espinoza-Fonseca, L., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 705-713 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

A traditional Chinese medicine, YXQN, reduces amyloid-induced cytotoxicity by inhibiting Aβ42 aggregation and fibril formation

Wang, L., Liu, S., Xu, J., Watanabe, N., Di, J., Wei, W., Mayo, K. H., Li, J. & Li, X., 2020, In : Current pharmaceutical design. 26, 7, p. 780-789 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Chemokines and galectins form heterodimers to modulate inflammation

Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A. K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Döring, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., Gabius, H. J. & 2 others, von Hundelshausen, P. & Mayo, K. H., Apr 3 2020, In : EMBO Reports. 21, 4, e47852.

Research output: Contribution to journalArticle

Open Access

Co-crystal Structure of Thermosynechococcus elongatus Sucrose Phosphate Synthase With UDP and Sucrose-6-Phosphate Provides Insight Into Its Mechanism of Action Involving an Oxocarbenium Ion and the Glycosidic Bond

Li, Y., Yao, Y., Yang, G., Tang, J., Ayala, G. J., Li, X., Zhang, W., Han, Q., Yang, T., Wang, H., Mayo, K. H. & Su, J., May 26 2020, In : Frontiers in Microbiology. 11, 1050.

Research output: Contribution to journalArticle

Open Access

Enhanced Molecular Tension Sensor Based on Bioluminescence Resonance Energy Transfer (BRET)

Aird, E. J., Tompkins, K. J., Ramirez, M. P. & Gordon, W. R., Jan 24 2020, In : ACS Sensors. 5, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution

Yang, T., Yao, Y., Wang, X., Li, Y., Si, Y., Li, X., Ayala, G. J., Wang, Y., Mayo, K. H., Tai, G., Zhou, Y. & Su, J., Jan 28 2020, In : Glycobiology. 30, 2, p. 120-129 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion

Pan, Y., Zhao, Y., Kuang, R., Liu, H., Sun, D., Mao, T., Jiang, K., Yang, X., Watanabe, N., Mayo, K. H., Lin, Q. & Li, J., Nov 2020, In : Materials Science and Engineering C. 116, 111158.

Research output: Contribution to journalArticle

Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

Larsen, E. K., Weber, D. K., Wang, S., Gopinath, T., Blackwell, D. J., Dalton, M. P., Robia, S. L., Gao, J. & Veglia, G., Jan 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 1, 183034.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity

Jones, B. J., Evans, R. L., Mylrea, N. J., Chaudhury, D., Luo, C., Guan, B., Pierce, C. T., Gordon, W. R., Wilmot, C. M. & Kazlauskas, R. J., 2020, In : PloS one. 15, 6, p. e0235341

Research output: Contribution to journalArticle

Open Access

Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Lindsay, A., Baumann, C. W., Rebbeck, R. T., Yuen, S. L., Southern, W. M., Hodges, J. S., Cornea, R. L., Thomas, D. D., Ervasti, J. M. & Lowe, D. A., Feb 1 2020, In : Skeletal Muscle. 10, 1, 3.

Research output: Contribution to journalArticle

Open Access

Multi-receiver solid-state NMR using polarization optimized experiments (POE) at ultrafast magic angle spinning

Gopinath, T., Weber, D. K. & Veglia, G., May 1 2020, In : Journal of biomolecular NMR. 74, 4-5, p. 267-285 19 p.

Research output: Contribution to journalArticle

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Olivieri, C., Wang, Y., Li, G. C., Subrahmanian, M. V., Kim, J., Stultz, B. R., Neibergall, M., Porcelli, F., Muretta, J. M., Thomas, D. D., Gao, J., Blumenthal, D. K., Taylor, S. S. & Veglia, G., Apr 2020, In : eLife. 9, e55607.

Research output: Contribution to journalArticle

Open Access

Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease

Sternisha, S. M., Whittington, A. C., Martinez Fiesco, J. A., Porter, C., McCray, M. M., Logan, T., Olivieri, C., Veglia, G., Steinbach, P. J. & Miller, B. G., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1109-1118 10 p.

Research output: Contribution to journalArticle

Programmable Assembly of Adeno-Associated Virus-Antibody Composites for Receptor-Mediated Gene Delivery

Zdechlik, A. C., He, Y., Aird, E. J., Gordon, W. R. & Schmidt, D., Apr 15 2020, In : Bioconjugate Chemistry. 31, 4, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons

Gerlits, O., Weiss, K. L., Blakeley, M. P., Veglia, G., Taylor, S. S. & Kovalevsky, A., 2020, Methods in Enzymology. Academic Press Inc., p. 311-331 21 p. (Methods in Enzymology; vol. 634).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Open Access
1 Scopus citations

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

McCarthy, M. R., Savich, Y., Cornea, R. L. & Thomas, D. D., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1090-1100 11 p.

Research output: Contribution to journalArticle

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, R. T., Singh, D. P., Janicek, K. A., Bers, D. M., Thomas, D. D., Launikonis, B. S. & Cornea, R. L., Dec 1 2020, In : Scientific reports. 10, 1, 1791.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Social stress is lethal in the mdx model of Duchenne muscular dystrophy

Razzoli, M., Lindsay, A., Law, M. L., Chamberlain, C. M., Southern, W. M., Berg, M., Osborn, J., Engeland, W. C., Metzger, J. M., Ervasti, J. M. & Bartolomucci, A., May 2020, In : EBioMedicine. 55, 102700.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structure–function studies of galectin-14, an important effector molecule in embryology

Si, Y., Li, Y., Yang, T., Li, X., Ayala, G. J., Mayo, K. H., Tai, G., Su, J. & Zhou, Y., 2020, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

3 Scopus citations
2019

An enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)

Aird, E. J., Tompkins, K. J. & Gordon, W. R., Apr 24 2019

Research output: Other contribution

Open Access

A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

Wook Park, S., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., Lin, Y. L., Kagechika, H., Mayo, K. H. & Wei, L. N., Dec 1 2019, In : Scientific reports. 9, 1, 10929.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins

Hall, J. W., Lima, B. P., Herbomel, G. G., Gopinath, T., McDonald, L. A., Shyne, M. T., Lee, J. K., Kreth, J., Ross, K. F., Veglia, G. & Herzberg, M. C., May 7 2019, In : Science signaling. 12, 580, eaas9941.

Research output: Contribution to journalArticle

1 Scopus citations

A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Duggirala, N. K., Li, J., Krishna Kumar, N. S., Tata, G. & Suryanarayanan, R., 2019, In : Chemical Communications. 55, 39, p. 5551-5554 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label

Binder, B. P., Thompson, A. R. & Thomas, D. D., Jul 23 2019, In : Biophysical journal. 117, 2, p. 319-330 12 p.

Research output: Contribution to journalArticle

A toolkit for studying cell surface shedding of diverse transmembrane receptors

Hayward, A. N., Aird, E. J. & Gordon, W. R., Jun 2019, In : eLife. 8, e46983.

Research output: Contribution to journalArticle

Open Access
Open Access

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Walweel, K., Gomez-Hurtado, N., Rebbeck, R. T., Oo, Y. W., Beard, N. A., Molenaar, P., dos Remedios, C., van Helden, D. F., Cornea, R. L., Knollmann, B. C. & Laver, D. R., May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 96-106 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Circulating tumor biomarkers in meningiomas reveal a signature of equilibrium between tumor growth and immune modulation

Erkan, E. P., Ströbel, T., Dorfer, C., Sonntagbauer, M., Weinhäusel, A., Saydam, N. & Saydam, O., Sep 1 2019, In : Frontiers in Oncology. 9, SEP, 1031.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis

Valberg, S. J., Soave, K., Williams, Z. J., Perumbakkam, S., Schott, M., Finno, C. J., Petersen, J. L., Fenger, C., Autry, J. M. & Thomas, D. D., Mar 1 2019, In : Journal of veterinary internal medicine. 33, 2, p. 933-941 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C. M., Feb 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Corrigendum to “An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature” (Vaccine (2018) 36(21) (3054–3060), (S0264410X1830433X), (10.1016/j.vaccine.2018.03.064))

Huijbers, E. J. M., van Beijnum, J. R., Lê, C. T., Langman, S., Nowak-Sliwinska, P., Mayo, K. H. & Griffioen, A. W., Jul 9 2019, In : Vaccine. 37, 30, p. 4231-4232 2 p.

Research output: Contribution to journalComment/debate

Open Access

Crystal structure of the Wheat dwarf virus Rep domain Everett Blake A.

Everett, B. A., Litzau, L. A., Tompkins, K., Shi, K., Nelson, A., Aihara, H., Evans, R. L. E. & Gordon, W. R., Dec 1 2019, In : Acta Crystallographica Section F: Structural Biology Communications. 75, p. 744-749 6 p.

Research output: Contribution to journalArticle

Open Access

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Walker, C., Wang, Y., Olivieri, C., Karamafrooz, A., Casby, J., Bathon, K., Calebiro, D., Gao, J., Bernlohr, D. A., Taylor, S. S. & Veglia, G., Aug 28 2019, In : Science advances. 5, 8, eaaw9298.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Cysteine-ethylation of tissue-extracted membrane proteins as a tool to detect conformational states by solid-state NMR spectroscopy

Weber, D. K., Bader, T., Larsen, E. K., Wang, S., Gopinath, T., Distefano, M. & Veglia, G., 2019, Methods in Enzymology. Shukla, A. K. (ed.). Academic Press Inc., p. 281-304 24 p. (Methods in Enzymology; vol. 621).

Research output: Chapter in Book/Report/Conference proceedingChapter

Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway

Koehn, E. M., Latham, J. A., Armand, T., Evans, R. L., Tu, X., Wilmot, C. M., Iavarone, A. T. & Klinman, J. P., Mar 13 2019, In : Journal of the American Chemical Society. 141, 10, p. 4398-4405 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Dynamic allostery-based molecular workings of kinase:peptide complexes

Ahuja, L. G., Aoto, P. C., Kornev, A. P., Veglia, G. & Taylor, S. S., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 30, p. 15052-15061 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Extracellular vesicles as carriers of suicide mRNA and/or protein in cancer therapy

Erkan, E. P., Saydam, N., Chen, C. C. & Saydam, O., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 87-96 10 p. (Methods in Molecular Biology; vol. 1895).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Galectin-3 binds selectively to the terminal, non-reducing end of β(1→4)-galactans, with overall affinity increasing with chain length

Miller, M. C., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jan 1 2019, In : Glycobiology. 29, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

Wang, Y., V.S, M., Kim, J., Li, G., Ahuja, L. G., Aoto, P., Taylor, S. S. & Veglia, G., Dec 1 2019, In : Nature communications. 10, 1, 799.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Webber, B. R., Lonetree, C. L., Kluesner, M. G., Johnson, M. J., Pomeroy, E. J., Diers, M. D., Lahr, W. S., Draper, G. M., Slipek, N. J., Smeester, B. S., Lovendahl, K. N., McElroy, A. N., Gordon, W. R., Osborn, M. J. & Moriarity, B. S., Dec 1 2019, In : Nature communications. 10, 1, 5222.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
4 Scopus citations

Hybrid ligands with calixarene and thiodigalactoside groups: Galectin binding and cytotoxicity

Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H. & Pieters, R. J., Aug 21 2019, In : Organic Chemistry Frontiers. 6, 16, p. 2981-2990 10 p.

Research output: Contribution to journalArticle

Improving the quality of oriented membrane protein spectra using heat-compensated separated local field experiments

Wang, S., Gopinath, T. & Veglia, G., Nov 1 2019, In : Journal of biomolecular NMR. 73, 10-11, p. 617-624 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

Savich, Y., Binder, B. P., Thompson, A. R. & Thomas, D. D., Aug 5 2019, In : Journal of General Physiology. 151, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: Evidence for noncanonical interactions with the lectin's CRD β-sandwich F-face

Zhang, Z., Miller, M. C., Xu, X., Song, C., Zhang, F., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jul 19 2019, In : Glycobiology. 29, 8, p. 608-618 11 p.

Research output: Contribution to journalArticle

1 Scopus citations