Organization profile

Organization profile

The mission of the Center for Translational Medicine is to support the development of novel, investigator-initiated treatment strategies in order to facilitate the implementation of new therapies for patients and achieve new breakthroughs in medicine at the University. The Center has a well-equipped lab and a full-time staff and provides the infrastructure, expertise and resources necessary to translate innovative drugs, biological reagents and devices into Phase 1 clinical trials.  Working with innovators from across the University, the Center designs and conducts the preclinical studies necessary for IND/IDE development and supports Phase I clinical trial design and implementation, including manufacture of clinical product.

 

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Chemokine CCL2 Medicine & Life Sciences
Biguanides Medicine & Life Sciences
Mitochondria Chemical Compounds
Oncorhynchus mykiss Medicine & Life Sciences
Leukocytes Medicine & Life Sciences
Heme Medicine & Life Sciences
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Protein Renaturation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2022

Research Output 1989 2019

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Gorr, S. U., Flory, C. M. & Schumacher, R. J., May 1 2019, In : PloS one. 14, 5, e0216669.

Research output: Contribution to journalArticle

Open Access
antimicrobial peptides
Galleria mellonella
Toxicity
peptides
toxicity
1 Citation (Scopus)

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Apr 15 2019, In : Investigational New Drugs. 37, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Fluoroquinolones
Heterografts
Human Activities
Poisoning
2 Citations (Scopus)

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 othersFlory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journalComment/debate

Biguanides
Mitochondria
Heme
Cytochrome P-450 Enzyme System
Cell Biology