Center for Genome Engineering

Email[email protected]
Websitehttp://med.umn.edu/cge

Organization profile

We create and deploy genetically modified cells while educating the next generation of genetic engineers.

The Center for Genome Engineering (CGE) faculty advances the research and clinical objectives of the UMN’s medical enterprise, including our understanding of biological processes and ways to successfully modify living cells for many applications.

Keywords

QH426 Genetics

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

Georgiy Aslanidi
- gaslanidumnedu
Person: Member, Faculty
19962025
Julia Davydova
- davyd003umnedu
Person: Member, Faculty
20002025
Jeffrey A Gralnick
- gralnickumnedu
- Administration (CBS) - Associate Dean
- Plant and Microbial Biology - Professor
- Center for Genome Engineering
Person: Faculty, Executive, Administrative, and Managerial Staff
20002025

35 Active
169 Finished

Allogeneic, multiplex base edited, dual-targeted gamma delta CAR-T cell development for metastatic castration-resistant prostate cancer
Moriarity, B. S. (PI) & Webber, B. R. (CoI)
US DEPT OF DEFENSE ARMY
9/30/24 → 9/29/27
Project: Research project
Center for Functional Genomics of Immunotherapy (CFGI)
Largaespada, D. A. (PI), Moriarity, B. S. (CoI) & Stromnes, I. M. (CoI)
STATE OF MINNESOTA
3/1/24 → 3/31/26
Project: Research project
Cancer Center Support Grant
Miller, J. S. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI), Yee, D. (CoI), Zhang, L. (CoI) & Yee, D. (Prior Principal Investigator)
NIH NATIONAL CANCER INSTITUTE
2/1/24 → 1/31/29
Project: Research project

443 Article
43 Review article
23 Comment/debate
21 Chapter
More

Advancing gene targeting for primary immune deficiencies: Adenine base editing of the human IL2RG locus for correction of SCID-X1
McIvor, R. S., Eaton, E. J., Webber, B. R. & Moriarity, B. S., Jun 5 2024, In: Molecular Therapy. 32, 6, p. 1606-1608 3 p.
Research output: Contribution to journal › Comment/debate › peer-review
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies
Skeate, J. G., Pomeroy, E. J., Slipek, N. J., Jones, B. J., Wick, B. J., Chang, J. W., Lahr, W. S., Stelljes, E. M., Patrinostro, X., Barnes, B., Zarecki, T., Krueger, J. B., Bridge, J. E., Robbins, G. M., McCormick, M. D., Leerar, J. R., Wenzel, K. T., Hornberger, K. M., Walker, K. L. & Smedley, D. & 4 others, Largaespada, D. A., Otto, N., Webber, B. R. & Moriarity, B. S., Jun 5 2024, In: Molecular Therapy. 32, 6, p. 1817-1834 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
11 Scopus citations
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production
Dahlvang, J. D., Dick, J. K., Sangala, J. A., Kennedy, P. R., Pomeroy, E. J., Snyder, K. M., Moushon, J. M., Thefaine, C. E., Wu, J., Hamilton, S. E., Felices, M., Miller, J. S., Walcheck, B., Webber, B. R., Moriarity, B. S. & Hart, G. T., Apr 15 2023, In: Journal of Immunology. 210, 8, p. 1108-1122 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
8 Scopus citations

Cancer-fighting firm based on U of M research raises $42 million
Moriarity, B. S.
11/23/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
'Genetic scissors' of CRISPR in the spotlight
Voytas, D. F.
11/9/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
Behind the Clouds: The Life & Music of Zach Sobiech
Kluesner, M. G., Moriarity, B. S. & Webber, B. R.
10/14/20
1 item of Media coverage
Press/Media: Expert Comment or Interview