Center for Genome Engineering

Email[email protected]
Websitehttp://med.umn.edu/cge

Organization profile

We create and deploy genetically modified cells while educating the next generation of genetic engineers.

The Center for Genome Engineering (CGE) faculty advances the research and clinical objectives of the UMN’s medical enterprise, including our understanding of biological processes and ways to successfully modify living cells for many applications.

Keywords

QH426 Genetics

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

Julia Davydova
- davyd003umnedu
- Surgery - Associate Professor
- Institute for Molecular Virology
- Center for Genome Engineering
- Genetics Mechanisms of Cancer
Person: Member, Faculty
20002024
Perry B Hackett, Jr
- hacke004umnedu
Person: Member, Faculty, Medical School Affiliates
1966 …2024
David A Largaespada
- larga002umnedu
- Pediatric Hematology/Oncology - Professor
- Pharmaceutics - Adjunct Professor
- Institute for Molecular Virology
- Center for Genome Engineering
- Genetics Mechanisms of Cancer
Person: Member, Faculty, Adjunct Faculty
19902025

45 Active
159 Finished

Allogeneic, multiplex base edited, dual-targeted gamma delta CAR-T cell development for metastatic castration-resistant prostate cancer
Moriarity, B. S. (PI) & Webber, B. R. (CoI)
US DEPT OF DEFENSE ARMY
9/30/24 → 9/29/27
Project: Research project
Proof of concept studies for in vivo generated CAR-T cells that target B cell follicles as a treatment for HIV
Schmidt, D. (PI) & Skinner, P. J. (CoI)
MARPAM PHARMA LLC, NATIONAL INSTITUTES OF HEALTH (NIH)
3/15/24 → 2/28/25
Project: Research project
Center for Functional Genomics of Immunotherapy (CFGI)
Largaespada, D. A. (PI), Moriarity, B. S. (CoI) & Stromnes, I. M. (CoI)
STATE OF MINNESOTA
3/1/24 → 3/31/26
Project: Research project

458 Article
46 Review article
23 Comment/debate
20 Chapter
More

Development and testing of a versatile genome editing application reporter (V-GEAR) system
Kleinboehl, E. W., Laoharawee, K., Lahr, W. S., Jensen, J. D., Peterson, J. J., Bell, J. B., Webber, B. R. & Moriarity, B. S., Jun 13 2024, In: Molecular Therapy Methods and Clinical Development. 32, 2, 101253.
Research output: Contribution to journal › Article › peer-review

Open Access
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production
Dahlvang, J. D., Dick, J. K., Sangala, J. A., Kennedy, P. R., Pomeroy, E. J., Snyder, K. M., Moushon, J. M., Thefaine, C. E., Wu, J., Hamilton, S. E., Felices, M., Miller, J. S., Walcheck, B., Webber, B. R., Moriarity, B. S. & Hart, G. T., Apr 15 2023, In: Journal of Immunology. 210, 8, p. 1108-1122 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1
Osum, S. H., Oribamise, E. I., Corbière, S. M. A. S., Taisto, M., Jubenville, T., Coutts, A., Kirstein, M. N., Fisher, J., Moertel, C., Du, M., Bedwell, D., Largaespada, D. A. & Watson, A. L., Sep 12 2023, In: Molecular Therapy Nucleic Acids. 33, p. 227-239 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations

Cancer-fighting firm based on U of M research raises $42 million
Moriarity, B. S.
11/23/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
'Genetic scissors' of CRISPR in the spotlight
Voytas, D. F.
11/9/20
1 item of Media coverage
Press/Media: Expert Comment or Interview
Behind the Clouds: The Life & Music of Zach Sobiech
Kluesner, M. G., Moriarity, B. S. & Webber, B. R.
10/14/20
1 item of Media coverage
Press/Media: Expert Comment or Interview