Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Cerebellar Ataxia Chemical Compounds
Enzymes Medicine & Life Sciences
Nucleosides Medicine & Life Sciences
HIV-1 Medicine & Life Sciences
Antiviral Agents Medicine & Life Sciences
Proteins Medicine & Life Sciences
HIV Medicine & Life Sciences
Puromycin Medicine & Life Sciences

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No photo of Marzena A Baran

Marzena A Baran

No photo of Laurent Bonnac

Laurent Bonnac

No photo of Liqiang Chen

Projects 2005 2019

Research Output 1968 2017

2 Citations
1 Citations

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase

Tang, J., Kirby, K. A., Huber, A. D., Casey, M. C., Ji, J., Wilson, D. J., Sarafianos, S. G. & Wang, Z. Mar 10 2017 In : European Journal of Medicinal Chemistry. 128, p. 168-179 12 p.

Research output: Contribution to journalArticle

Ribonuclease H
DNA-Directed RNA Polymerases
RNA-Directed DNA Polymerase

A 2-hydroxyisoquinoline-1,3-dione active-site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase

Kirby, K. A., Myshakina, N. A., Christen, M. T., Chen, Y. L., Schmidt, H. A., Huber, A. D., Xi, Z., Kim, S., Rao, R. K., Kramer, S. T., Yang, Q., Singh, K., Parniak, M. A., Wang, Z., Ishima, R. & Sarafianos, S. G. Oct 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 10, e01351

Research output: Contribution to journalArticle

Ribonuclease H
HIV Reverse Transcriptase
Catalytic Domain
RNA-Directed DNA Polymerase