Center for Drug Design

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Nucleosides Medicine & Life Sciences
carbovir Medicine & Life Sciences
Antiviral Agents Medicine & Life Sciences
Organophosphonates Medicine & Life Sciences
NAD Medicine & Life Sciences
Inosine Monophosphate Medicine & Life Sciences
Derivatives Chemical Compounds
Puromycin Medicine & Life Sciences

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Profiles

No photo of Laurent Bonnac

Laurent Bonnac

Person: Research Faculty

20042018
No photo of Liqiang Chen

Liqiang Chen

Person: Faculty

20022019
No photo of Christine D Dreis

Christine D Dreis

Person: Researcher

Projects 2005 2023

Discovery and development of novel anti-HCMV agents targeting the UL89 terminase protein

Geraghty, R. J., Aihara, H., Wang, Z. & Xie, J.

NIH Nat'l Inst of Allergy & Infect Dis

1/25/19 → 12/31/23

Project: Research project

Proteins
terminase

Retinal Changes in Alzheimer's Disease (AD) and Cerebral Amyloid Staging Correlations, A Promising Early Biomarker in AD

More, S. S., Bell, W. R. & Flanagan, M. E.

Winston & Maxine Wallin Neuro Disc Fund

1/1/19 → 12/31/19

Project: Research project

Amyloid
Alzheimer Disease
Biomarkers

MultiRep Biofilm Reactor Customer Discovery

Salomon, C.

National Science Foundation

11/1/18 → 4/30/19

Project: Research project

Biofilms

Research Output 1969 2019

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

Tang, J., Huber, A. D., Pineda, D. L., Boschert, K. N., Wolf, J. J., Kankanala, J., Xie, J., Sarafianos, S. G. & Wang, Z., Feb 15 2019, In : European Journal of Medicinal Chemistry. p. 179-192 14 p.

Research output: Contribution to journal › Article

Virus Assembly
Capsid
Viruses
Hepatitis B virus
Viral Core Proteins

Discovery of Irreversible p97 Inhibitors

Ding, R., Zhang, T., Wilson, D. J., Xie, J., Williams, J., Xu, Y., Ye, Y. & Chen, L., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2814-2829 16 p.

Research output: Contribution to journal › Article

Amides
Mutagenesis
Cysteine
Mass Spectrometry
Neoplasms

FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity

Wang, Y. & Geraghty, R. J., Jan 15 2019, In : European Journal of Pharmaceutical Sciences. 127, p. 29-37 9 p.

Research output: Contribution to journal › Article

Endonucleases
Cytomegalovirus
Viral Genome
DNA
Viral DNA