Center for Drug Design

Tang, J., Kirby, K. A., Huber, A. D., Casey, M. C., Ji, J., Wilson, D. J., Sarafianos, S. G. & Wang, Z. Mar 10 2017 In : European Journal of Medicinal Chemistry. 128, p. 168-179 12 p.

Research output: Contribution to journal › Article

Ribonuclease H

DNA-Directed RNA Polymerases

HIV

Integrases

RNA-Directed DNA Polymerase

A 2-hydroxyisoquinoline-1,3-dione active-site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase

Kirby, K. A., Myshakina, N. A., Christen, M. T., Chen, Y. L., Schmidt, H. A., Huber, A. D., Xi, Z., Kim, S., Rao, R. K., Kramer, S. T., Yang, Q., Singh, K., Parniak, M. A., Wang, Z., Ishima, R. & Sarafianos, S. G. Oct 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 10, e01351

Research output: Contribution to journal › Article

Ribonuclease H

HIV Reverse Transcriptase

HIV-1

Catalytic Domain

RNA-Directed DNA Polymerase

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Profiles

Marzena A Baran

Laurent Bonnac

Liqiang Chen

Projects 2005 2019

Biological Control of White Nose Bat Syndrome -- Phase 2

Taking aim at HBV eradication using novel NRTIs, capsid

An ecological approach for biological control of WNS

Research Output 1968 2017

3-Acyl dihydroflavonols from poplar resins collected by honey bees are active against the bee pathogens Paenibacillus larvae and Ascosphaera apis

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase

A 2-hydroxyisoquinoline-1,3-dione active-site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase