Carcinogenesis and Chemoprevention

Research Output 1993 2019

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Article
2019
2 Citations (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Bellamri, M., Yao, L., Bonala, R., Johnson, F., von Weymarn, L. B. & Turesky, R., Jul 1 2019, In : Archives of Toxicology. 93, 7, p. 1893-1902 10 p.

Research output: Contribution to journalArticle

Tobacco
Carcinogens
DNA Adducts
Urinary Bladder
Amines
2 Citations (Scopus)

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

Lensing, C. J., Freeman, K. T., Schnell, S. M., Speth, R. C., Zarth, A. T. & Haskell-Luevano, C., Jan 10 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 144-158 15 p.

Research output: Contribution to journalArticle

Open Access
Melanocortin Receptors
G-Protein-Coupled Receptors
Melanocortins
Ligands
Arrestin

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S. G., Hecht, S. S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
Brassica
Beverages
Benzene
China
Placebos

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
Dinoprost
eicosanoids
smoking (habit)
Eicosanoids
Biomarkers

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M. N., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Biomarkers
Smoking
Confidence Intervals

Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells

Song, J. M., Im, J., Nho, R. S., Han, Y. H., Upadhyaya, P. & Kassie, F., Mar 1 2019, In : Molecular Carcinogenesis. 58, 3, p. 321-333 13 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Lung Neoplasms
Cell Survival
Cell Proliferation
Non-Small Cell Lung Carcinoma
2 Citations (Scopus)

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Jan 1 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
acrolein
Acrylonitrile
Acrolein
cigarettes
Acetylcysteine
1 Citation (Scopus)

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 1 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
eicosanoids
Eicosanoids
cigarettes
Prostaglandins F
Biomarkers
2 Citations (Scopus)

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA

NBGNU: A hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

Ge, Y., Lai, X., Li, J., Yu, R., Zhuang, Z., Sun, G., Cui, X., Zhang, N., Zhao, L., Upadhyaya, P. & Zhong, R., Feb 1 2019, In : Future Medicinal Chemistry. 11, 4, p. 269-284 16 p.

Research output: Contribution to journalArticle

Open Access
Prodrugs
DNA
O(6)-Methylguanine-DNA Methyltransferase
Guanine
Cell Death
1 Citation (Scopus)

Prediagnostic levels of urinary 8-epi-prostaglandin F2α and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma

Yuan, J. M., Grouls, M., Carmella, S. G., Wang, R., Heskin, A., Jiang, Y., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 989-997 9 p.

Research output: Contribution to journalArticle

Dinoprost
Dinoprostone
Hepatocellular Carcinoma
Biomarkers
Inflammation

Quantitation of Lipid Peroxidation Product DNA Adducts in Human Prostate by Tandem Mass Spectrometry: A Method That Mitigates Artifacts

Chen, H., Krishnamachari, S., Guo, J., Yao, L., Murugan, P., Weight, C. J. & Turesky, R., Sep 16 2019, In : Chemical research in toxicology. 32, 9, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

DNA Adducts
Tandem Mass Spectrometry
Artifacts
Lipid Peroxidation
Mass spectrometry

Truncated rank correlation (TRC) as a robust measure of test-retest reliability in mass spectrometry data

Lim, J., Yu, D., Kuo, H. C., Choi, H. & Walmsley, S. J., Jan 1 2019, In : Statistical Applications in Genetics and Molecular Biology. 18, 4, 20180056.

Research output: Contribution to journalArticle

Spearman's coefficient
Mass Spectrometry
Reproducibility of Results
Mass spectrometry
Noise
2018
9 Citations (Scopus)

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking
2 Citations (Scopus)

A Method for Biomonitoring of DNA Adducts in Exfoliated Urinary Cells by Mass Spectrometry

Yun, BH., Bellamri, M., Rosenquist, T. A. & Turesky, R., May 15 2018, (Accepted/In press) In : Analytical Chemistry.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Mass spectrometry
Tobacco
Carcinogens
Smoke
6 Citations (Scopus)
Open Access
Tobacco
Enantiomers
DNA Adducts
Metabolites
Carcinogens
1 Citation (Scopus)

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

Wang, Y., Eans, S. O., Stacy, H. M., Chanickal Narayanapillai, S., Sharma, A., Fujioka, N., Haddad, L., McLaughlin, J., Avery, B. A. & Xing, C., May 1 2018, In : PloS one. 13, 5, e0197940.

Research output: Contribution to journalArticle

Open Access
kava
Kava
Pharmacokinetics
isotope dilution technique
Liquid chromatography
3 Citations (Scopus)

Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in humans

Bellamri, M., Wang, Y., Yonemori, K., White, K. K., Wilkens, L. R., Le Marchand, L. & Turesky, R., Dec 31 2018, In : Carcinogenesis. 39, 12, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

Environmental Monitoring
Carcinogens
Meat
Albumins
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
1 Citation (Scopus)

Contribution of Tobacco Use and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone to Three Methyl DNA Adducts in Urine

Wang, Y., Chanickal Narayanapillai, S., Hu, Q., Fujioka, N. & Xing, C., Sep 17 2018, In : Chemical research in toxicology. 31, 9, p. 836-838 3 p.

Research output: Contribution to journalArticle

Tobacco
DNA Adducts
Tobacco Use
Carcinogens
Urine

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

Hwa Yun, B., Guo, J., Bellamri, M. & Turesky, R. J., 2018, In : Mass Spectrometry Reviews.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., al'Absi, M. N., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. S., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
hydroxypropyl methacrylate
Nicotine
Smoke
Tobacco Products
Randomized Controlled Trials
Vegetables
Acetylcysteine
Urine
Brassica
Isothiocyanates
1 Citation (Scopus)

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N- glucuronide by African American Smokers

Murphy, S. E., von Weymarn, L. B., Parenteau, M., Stepanov, I., Tiirikainen, M., Lemarchand, L. & Park, S. L., Mar 19 2018, In : Chemical Research in Toxicology. 31, 3, p. 168-175 8 p.

Research output: Contribution to journalArticle

Glucuronides
African Americans
Genotype
Glucuronosyltransferase
Tobacco
1 Citation (Scopus)

Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates

Van Herck, S., Deswarte, K., Nuhn, L., Zhong, Z., Portela Catani, J. P., Li, Y., Sanders, N. N., Lienenklaus, S., De Koker, S., Lambrecht, B. N., David, S. A. & De Geest, B. G., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Amphiphiles
Micelles
Block copolymers
Lymph Nodes
Chemical activation
3 Citations (Scopus)
Open Access
Meats
Carcinogens
Meat
Prostate
Chemical activation
7 Citations (Scopus)
Open Access
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
6 Citations (Scopus)

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

Nuhn, L., De Koker, S., Van Lint, S., Zhong, Z., Catani, J. P., Combes, F., Deswarte, K., Li, Y., Lambrecht, B. N., Lienenklaus, S., Sanders, N. N., David, S. A., Tavernier, J. & De Geest, B. G., Nov 8 2018, In : Advanced Materials. 30, 45, 1803397.

Research output: Contribution to journalArticle

Tumors
Chemical activation
Nanoparticles
T-cells
Medical nanotechnology
5 Citations (Scopus)
Epidermal Growth Factor Receptor
Aspirin
Nitric Oxide
Carcinogenesis
Lung
20 Citations (Scopus)

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., Vandenbussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R., Yun, BH., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Cytology
Aneuploidy
Urinary Bladder Neoplasms
Genes
Cell Biology
13 Citations (Scopus)

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Nuhn, L., Van Hoecke, L., Deswarte, K., Schepens, B., Li, Y., Lambrecht, B. N., De Koker, S., David, S. A., Saelens, X. & De Geest, B. G., Sep 1 2018, In : Biomaterials. 178, p. 643-651 9 p.

Research output: Contribution to journalArticle

Viral Vaccines
Vaccines
Cancer Vaccines
Subunit Vaccines
Molecules
4 Citations (Scopus)

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Dinoprost
Lung Neoplasms
Cohort Studies
Biomarkers
Smoking
5 Citations (Scopus)
DNA Adducts
High performance liquid chromatography
Carcinogens
Amines
Mass spectrometry
2017
1 Citation (Scopus)

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
7 Citations (Scopus)

Analysis of Alkaloids in Areca Nut-Containing Products by Liquid Chromatography-Tandem Mass Spectrometry

Jain, V., Garg, A., Parascandola, M., Chaturvedi, P., Khariwala, S. S. & Stepanov, I., Mar 8 2017, In : Journal of agricultural and food chemistry. 65, 9, p. 1977-1983 7 p.

Research output: Contribution to journalArticle

Open Access
Areca
Nuts
Liquid chromatography
Tandem Mass Spectrometry
Alkaloids
2 Citations (Scopus)
Open Access
N'-nitrosonornicotine
Enantiomers
Tandem Mass Spectrometry
Mass spectrometry
Urine
2 Citations (Scopus)

A Rapid Throughput Method to Extract DNA from Formalin-Fixed Paraffin-Embedded Tissues for Biomonitoring Carcinogenic DNA Adducts

Yun, BH., Xiao, S., Yao, L., Krishnamachari, S. R., Rosenquist, T. A., Dickman, K. G., Grollman, A. P., Murugan, P., Weight, C. J. & Turesky, R., Dec 18 2017, In : Chemical research in toxicology. 30, 12, p. 2130-2139 10 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Environmental Monitoring
Paraffin
Formaldehyde
Throughput
13 Citations (Scopus)

Customized Consensus Spectral Library Building for Untargeted Quantitative Metabolomics Analysis with Data Independent Acquisition Mass Spectrometry and MetaboDIA Workflow

Chen, G., Walmsley, S. J., Cheung, G. C. M., Chen, L., Cheng, C. Y., Beuerman, R. W., Wong, T. Y., Zhou, L. & Choi, H., May 2 2017, In : Analytical chemistry. 89, 9, p. 4897-4906 10 p.

Research output: Contribution to journalArticle

Open Access
Mass spectrometry
Ions
Metabolomics
Liquid chromatography
Bioinformatics
10 Citations (Scopus)

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
10 Citations (Scopus)

Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts

Guo, J., Villalta, P. W. & Turesky, R., Nov 7 2017, In : Analytical chemistry. 89, 21, p. 11728-11736 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Adducts
Mass spectrometry
Screening
Ions
Deoxyribose
6 Citations (Scopus)
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
2016
3 Citations (Scopus)

Adsorbing/dissolving Lyoprotectant Matrix Technology for Non-cryogenic Storage of Archival Human Sera

Solivio, M. J. V., Less, R., Rynes, M. L., Kramer, M. & Aksan, A., Apr 12 2016, In : Scientific reports. 6, 24186.

Research output: Contribution to journalArticle

Vitrification
Biomarkers
Technology
Serum
Matrix Metalloproteinases
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
14 Citations (Scopus)

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
11 Citations (Scopus)

Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases

Cai, T., Yao, L. & Turesky, R., May 16 2016, In : Chemical research in toxicology. 29, 5, p. 879-891 13 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Glucuronides
Amines
Metabolites
Liver
19 Citations (Scopus)
Deoxyguanosine
DNA Adducts
Meats
Liquid chromatography
Carcinogens
3 Citations (Scopus)

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Chanickal Narayanapillai, S., von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
2 Citations (Scopus)

Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O 6 -Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice

Chanickal Narayanapillai, S., Lin, S. H., Leitzman, P., Upadhyaya, P., Baglole, C. J. & Xing, C., Nov 21 2016, In : Chemical research in toxicology. 29, 11, p. 1828-1834 7 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Tobacco
Carcinogens
Nutrition
Lung
12 Citations (Scopus)

DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Zarth, A. T., Upadhyaya, P., Yang, J. & Hecht, S. S., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 380-389 10 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens