Research Output

2020

Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors

Mo, C., Zhang, Z., Li, Y., Huang, M., Zou, J., Luo, J., Tu, Z-C., Xu, Y., Ren, X., Ding, K. & Lu, X., Jan 9 2020, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2019
5 Scopus citations

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Bosnakovski, D., da Silva, M. T., Sunny, S. T., Ener, E. T., Toso, E. A., Yuan, C., Cui, Z., Walters, M. A., Jadhav, A. & Kyba, M., Sep 11 2019, In : Science advances. 5, 9, eaaw7781.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Bellamri, M., Yao, L., Bonala, R., Johnson, F., von Weymarn, L. B. & Turesky, R., Jul 1 2019, In : Archives of Toxicology. 93, 7, p. 1893-1902 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

Lensing, C. J., Freeman, K. T., Schnell, S. M., Speth, R. C., Zarth, A. T. & Haskell-Luevano, C., Jan 10 2019, In : Journal of medicinal chemistry. 62, 1, p. 144-158 15 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Emerging technologies in mass spectrometry-based DNA adductomics

Guo, J. & Turesky, R. J., Jun 2019, In : High-Throughput. 8, 2, 13.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Fragmentation Spectra Prediction and DNA Adducts Structural Determination

Carrà, A., Macaluso, V., Villalta, P. W., Spezia, R. & Balbo, S., Dec 1 2019, In : Journal of the American Society for Mass Spectrometry. 30, 12, p. 2771-2784 14 p.

Research output: Contribution to journalArticle

Genome-wide mapping of 8-oxo-7,8-dihydro-2′-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells

Amente, S., Di Palo, G., Scala, G., Castrignanò, T., Gorini, F., Cocozza, S., Moresano, A., Pucci, P., Ma, B., Stepanov, I., Lania, L., Pelicci, P. G., Dellino, G. I. & Majello, B., Jan 10 2019, In : Nucleic acids research. 47, 1, p. 221-236 16 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells

Song, J. M., Im, J., Nho, R. S., Han, Y. H., Upadhyaya, P. & Kassie, F., Mar 2019, In : Molecular Carcinogenesis. 58, 3, p. 321-333 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. & Hecht, S. S., Jan 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Methods and Challenges for Computational Data Analysis for DNA Adductomics

Walmsley, S. J., Guo, J., Wang, J., Villalta, P. W. & Turesky, R. J., Nov 18 2019, In : Chemical research in toxicology. 32, 11, p. 2156-2168 13 p.

Research output: Contribution to journalReview article

1 Scopus citations

NBGNU: A hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

Ge, Y., Lai, X., Li, J., Yu, R., Zhuang, Z., Sun, G., Cui, X., Zhang, N., Zhao, L., Upadhyaya, P. & Zhong, R., Feb 2019, In : Future Medicinal Chemistry. 11, 4, p. 269-284 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats

Harris, A. C., Muelken, P., Swain, Y., Palumbo, M., Jain, V., Goniewicz, M. L., Stepanov, I. & LeSage, M. G., Oct 1 2019, In : Drug and alcohol dependence. 203, p. 51-60 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prediagnostic levels of urinary 8-epi-prostaglandin F and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma

Yuan, J. M., Grouls, M., Carmella, S. G., Wang, R., Heskin, A., Jiang, Y., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 989-997 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

Ma, B., Stepanov, I. & Hecht, S. S., Jan 1 2019, In : Toxics. 7, 1, 16.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage

Carrà, A., Guidolin, V., Dator, R. P., Upadhyaya, P., Kassie, F., Villalta, P. W. & Balbo, S., Oct 24 2019, In : Frontiers in Chemistry. 7, 658.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Truncated rank correlation (TRC) as a robust measure of test-retest reliability in mass spectrometry data

Lim, J., Yu, D., Kuo, H. C., Choi, H. & Walmsley, S., Jan 1 2019, In : Statistical Applications in Genetics and Molecular Biology. 18, 4, 20180056.

Research output: Contribution to journalArticle

2018

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
Open Access
7 Scopus citations

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

Wang, Y., Eans, S. O., Stacy, H. M., Narayanapillai, S. C., Sharma, A., Fujioka, N., Haddad, L., McLaughlin, J., Avery, B. A. & Xing, C., May 2018, In : PloS one. 13, 5, e0197940.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in humans

Bellamri, M., Wang, Y., Yonemori, K., White, K. K., Wilkens, L. R., Le Marchand, L. & Turesky, R. J., Dec 31 2018, In : Carcinogenesis. 39, 12, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Contribution of Tobacco Use and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone to Three Methyl DNA Adducts in Urine

Wang, Y., Narayanapillai, S., Hu, Q., Fujioka, N. & Xing, C., Sep 17 2018, In : Chemical research in toxicology. 31, 9, p. 836-838 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Data Descriptor: A prototypic small molecule database for bronchoalveolar lavage-based metabolomics

Walmsley, S., Cruickshank-Quinn, C., Quinn, K., Zhang, X., Petrache, I., Bowler, R. P., Reisdorph, R. & Reisdorph, N., Apr 17 2018, In : Scientific Data. 5, 180060.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., Al'Absi, M., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J. S., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. G., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Erratum: Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (eLife (2018) 7 PII: e43237)

Springer, S. U., Chen, C. H., Rodriguez Pena, M. D. C., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Nov 12 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Formalin-fixed paraffin-embedded tissues-an untapped biospecimen for biomonitoring DNA adducts by mass spectrometry

Yun, B. H., Guo, J. & Turesky, R. J., Jan 1 2018, In : Toxics. 6, 2, 30.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue

Yoo, E., Salyer, A. C. D., Brush, M. J. H., Li, Y., Trautman, K. L., Shukla, N. M., De Beuckelaer, A., Lienenklaus, S., Deswarte, K., Lambrecht, B. N., De Geest, B. G. & David, S. A., Aug 15 2018, In : Bioconjugate Chemistry. 29, 8, p. 2741-2754 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N- glucuronide by African American Smokers

Murphy, S. E., Von Weymarn, L. B., Parenteau, M., Stepanov, I., Tiirikainen, M., Lemarchand, L. & Park, S. L., Mar 19 2018, In : Chemical research in toxicology. 31, 3, p. 168-175 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates

Van Herck, S., Deswarte, K., Nuhn, L., Zhong, Z., Portela Catani, J. P., Li, Y., Sanders, N. N., Lienenklaus, S., De Koker, S., Lambrecht, B. N., David, S. A. & De Geest, B. G., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
5 Scopus citations

Method for Biomonitoring DNA Adducts in Exfoliated Urinary Cells by Mass Spectrometry

Yun, B. H., Bellamri, M., Rosenquist, T. A. & Turesky, R. J., Aug 21 2018, In : Analytical chemistry. 90, 16, p. 9943-9950 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
10 Scopus citations

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

Nuhn, L., De Koker, S., Van Lint, S., Zhong, Z., Catani, J. P., Combes, F., Deswarte, K., Li, Y., Lambrecht, B. N., Lienenklaus, S., Sanders, N. N., David, S. A., Tavernier, J. & De Geest, B. G., Nov 8 2018, In : Advanced Materials. 30, 45, 1803397.

Research output: Contribution to journalArticle

19 Scopus citations
11 Scopus citations

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., Vandenbussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Nuhn, L., Van Hoecke, L., Deswarte, K., Schepens, B., Li, Y., Lambrecht, B. N., De Koker, S., David, S. A., Saelens, X. & De Geest, B. G., Sep 2018, In : Biomaterials. 178, p. 643-651 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
8 Scopus citations
2017

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

Lensing, C. J., Adank, D. N., Wilber, S. L., Freeman, K. T., Schnell, S. M., Speth, R. C., Zarth, A. T. & Haskell-Luevano, C., Jun 21 2017, In : ACS Chemical Neuroscience. 8, 6, p. 1262-1278 17 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations