Carcinogenesis and Chemoprevention

Active

Single-Arm Phase II Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment ofPatients receiving Neoadjuvant Chemotherapy with Advanced-Stage Ovarian, Fallopian Tube or PrimaryPeritoneal Cancer who are Folate Receptor positive

Erickson, B. K. (PI)

THE UNIVERSITY OF ALABAMA, IMMUNOGEN, INC

9/1/24 → 8/31/27

Project: Research project

FMT CAPSULE DE, FMT CapDE, MTP-101C, in Kidney Stone Patients

Khoruts, A. (PI)

INTERMOUNTAIN HEALTH CARE, INC

4/24/24 → 4/24/29

Project: Research project

Engineering Degradability into Corn-based Plastics

Hoye, T. R. (PI) & Tonks, I. (CoI)

MN CORN RES AND PROMOTION COUN

4/12/24 → 3/31/25

Project: Research project

Standardized Microbiota Transplant Therapy in Crohn???s Disease. Pilot Trial

Khoruts, A. (PI) & Vaughn, B. P. (CoI)

LEONA M & HARRY B HELMSLEY CHAR. TRUST

3/1/24 → 2/28/27

Project: Research project

Cancer Center Support Grant

Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/24 → 1/31/29

Project: Research project

Outcomes of Fecal Microbiota Transplantation (FMT) for the Treatment of Uncomplicated Diverticulitis: aPilot Study

Khoruts, A. (PI)

UNIVERSITY OF MASSACHUSETTS

1/3/24 → 8/14/26

Project: Research project

HORMEL: A dual arm randomized cross-over trial to assess wHether ORganic grass-fed cow MEat increases Levels of SCFAs and SCFA producing bacteria, and reduces inflammatory type 2 diabetes biomarkers including A1c

Hilakivi-Clarke, L. (PI)

HORMEL FOODS

12/11/23 → 12/10/25

Project: Research project

Rocuronium Bromide for Non Melanoma Skin Cancer Prevention

Bode, A. M. (PI), Gurvich, V. J. (CoI), Schumacher, R. J. (CoI) & Zhang, T. (CoI)

VENN FOUNDATION

12/1/23 → 11/30/25

Project: Research project

Feasibility, Safety and Potential Efficacy of Fecal Microbiota Transplantation for Gastrointestinal AcuteGraft-Versus-Host Disease In Children Following Hematopietic Cell Transplant.

Khoruts, A. (PI)

ST. JUDE CHILDREN'S RESEARCH HOSPITAL

10/13/23 → 10/12/28

Project: Research project

Third-party fecal microbiota transplantation to prevent acute graft-versus-host disease after allogeneic hematopoietic cell transplantation: a dose-finding study

Khoruts, A. (PI)

FRED HUTCHINSON CANCER CENTER, LEUKEMIA AND LYMPHOMA SOC

10/1/23 → 9/30/25

Project: Research project

Research Infrastructure: MRI Track 1 Acquisition of a Dual-Reagent Chemical Ion Mass Spectrometer for Direct and Detailed Measurements off Atmospheric Chemical Fluxes

Millet, D. B. (PI), Bazurto, J. V. (CoI), Griffis, T. J. (CoI), Hogan, C. (CoI) & Vermeuel, M. P. (CoI)

THE NATIONAL SCIENCE FOUNDATION

10/1/23 → 9/30/26

Project: Research project

High-Throughput Laboratory Analysis of Tobacco-Related Biomarkers in Biospecimens: Serum and Urine Samples for Cotinine, Trans-3???-hydroxycotinine, 4-Methylnitrosamino-1-[3-pyridyl]-1-butanol (NNAL), and Total Nicotine Equivalents

Murphy, S. E. (PI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

9/25/23 → 3/24/27

Project: Research project

Increasing access to cancer trials in Minnesota (InACT-MN)

Erickson, B. K. (PI), Geller, M. A. (CoI), Greeno, E. W. (CoI), Kratzke, R. A. (CoI), Ondrey, F. G. (CoI), Teoh, D. G. (CoI) & Yee, D. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/18/23 → 8/31/28

Project: Research project

Mechanisms of PhIP-induced dopaminergic neurotoxicity

Turesky, R. (PI) & Bellamri, M. (CoI)

PURDUE UNIVERSITY, NIH NATL INST OF ENVIRON HEALTH SCIENCES

9/15/23 → 8/31/26

Project: Research project

Fecal Microbiota Transplantation for GVHD

Khoruts, A. (PI)

FRED HUTCHINSON CANCER CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/23 → 6/30/25

Project: Research project

Wnt-beta-Catenin Project Chemical Biology Consortium 2 months

Georg, G. (PI), Gurvich, V. J. (CoI) & Tretyakova, N. Y. (CoI)

LEIDOS BIOMEDICAL RESEARCH, INC., NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/23 → 2/28/25

Project: Research project

Characterize Hybrid Peptide Formation in Beta Cells

Wang, J. (PI) & Walmsley, S. J. (CoI)

UNIVERSITY OF COLORADO DENVER, NIH NATL INST OF DIABETES/DIG/KIDNEY DIS

8/22/23 → 6/30/27

Project: Research project

Synthesis, Structure, and Mechanism of Biorelevant Molecules and Reactions

Hoye, T. R. (PI)

NIH NIGMS NATL INST OF GENERAL

8/1/23 → 7/31/28

Project: Research project

Effect of maternal obesity on breast cancer among offspring: role of the gut microbiota

Hilakivi-Clarke, L. (PI), De Oliveira Andrade, F. (CoI), Jin, L. (CoI), Staley, C. (CoI) & Verma, V. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

7/15/23 → 6/30/28

Project: Research project

Discovery and development of OGG1 activators as precision drugs for modification of Alzheimer?s disease progression

Gurvich, V. J. (PI) & Georg, G. (CoI)

LUCIOLE PHARMACEUTICALS, INC., NATIONAL INSTITUTES OF HEALTH (NIH)

7/1/23 → 8/31/25

Project: Research project

Capsule Fecal Microbiota Transplant for Hidradenitis Suppurativa

Goldfarb, N. (PI), Guan, W. (CoI), Jahansouz, C. (CoI), Khoruts, A. (CoI) & Staley, C. (CoI)

HIDRADENITIS SUPPURATIVA FOUNDATION, INC

7/1/23 → 6/30/25

Project: Research project

A Randomized Controlled Trial to Further Microbiota Therapy for Antibiotic-Resistant BacterialColonization in Inpatients (FAIR)

Khoruts, A. (PI)

EMORY UNIVERSITY, CENTERS FOR DISEASE CONTROL & PREVENTION

6/1/23 → 5/31/25

Project: Research project

MARVEL: A Multidisciplinary Assessment of Risks from Vaping during Early Life

Murphy, S. E. (PI) & Stepanov, I. (CoI)

WAKE FOREST UNIVERSITY, NIH NATIONAL CANCER INSTITUTE (NCI)

5/3/23 → 4/30/28

Project: Research project

A Novel Melanoma Vaccine Based on a Shared Neoantigen and a Liquid Polymer Platform

Wang, C. (PI), Gurvich, V. J. (CoI) & Suryanarayanan, R. (CoI)

TREKKA THERAPEUTICS, LLC, NATIONAL INSTITUTES OF HEALTH (NIH)

3/1/23 → 2/28/25

Project: Research project

Antiparasitic metabolites from deep subterranean fungi for the treatment of cryptosporidiosis, an AIDS defining disease

Salomon, C. (PI)

NIH Nat'l Inst of Allergy & Infect Dis

3/1/23 → 2/28/25

Project: Research project

Evaluating Cigarette Relighting Behavior: Prevalence, Correlates, Toxicant Exposure, and Implications forCessation

Stepanov, I. (PI)

RUTGERS UNIVERSITY, NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/23 → 1/31/26

Project: Research project

Functional Dissection of Metabolic-Sensing Proline Hydroxylation Pathways

Chen, Y. (PI)

NIH NIGMS NATL INST OF GENERAL

2/1/23 → 1/31/29

Project: Research project

phase II trial evaluating the safety and efficacy of MTT in peanut allergic subjects

Khoruts, A. (PI)

BOSTON CHILDREN'S HOSPITAL, FOOD ALLERGY FUND

1/15/23 → 1/14/27

Project: Research project

A Phase 1/2, First-in-Human, Multicenter, Open-Label Study of SQZ-eAPC-HPV as Monotherapy and in Combinationwith Immune Checkpoint Inhibitor(s) in Patients with HPV16+ Recurrent, Locally Advanced, or Metastatic SolidTumors

Fujioka, N. (PI)

SQZ BIOTECHNOLOGIES COMPANY

11/23/22 → 11/23/27

Project: Research project

M4OC-Prevent 2.0: Phase IIb Trial of Metformin for Oral Cancer Prevention

Ondrey, F. G. (PI)

THE UNIVERSITY OF ARIZONA, NIH NATIONAL CANCER INSTITUTE (NCI)

11/15/22 → 7/31/25

Project: Research project

MPH Scholarship Program: Strengthening the Public Health Workforce Through an Academic/Governmental Public Health Partnership

Wattenberg, E. V. (PI)

US Dept. of Health & Human Services HRSA

9/30/22 → 9/29/25

Project: Research project

Chemical Synthesis Facility

Gurvich, V. J. (PI) & Georg, G. (CoI)

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

9/29/22 → 9/28/25

Project: Research project

Dissecting the role of acetaldehyde in oral carcinogenesis

Balbo, S. (PI), Johnson, A. J. (CoI), Rendahl, A. (CoI) & Walmsley, S. J. (CoI)

NIH Nat'l Inst. on Alcohol Abuse & Alcoh

9/20/22 → 8/31/27

Project: Research project

Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking

Hecht, S. S. (PI), Fujioka, N. (CoI), Hatsukami, D. K. (CoI), Henzler, C. (CoI), Murphy, S. E. (CoI), Stepanov, I. (CoI) & Tretyakova, N. Y. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/16/22 → 8/31/27

Project: Research project

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

Ondrey, F. G. (PI) & Li, F. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/15/22 → 8/31/26

Project: Research project

Hexadehydro-Diels-Alder (HDDA) Reaction-Enabled Synthesis of Structurally Elaborate, Polycyclic Aromatic Compounds

Hoye, T. R. (PI)

THE NATIONAL SCIENCE FOUNDATION

9/1/22 → 8/31/25

Project: Research project

Midwest Murine-Tissue Mapping Center (MM-TMC)

Robbins, P. D. (PI), Adeyi, O. (CoI), Bartolomucci, A. (CoI), Beckman, K. B. (CoI), Butterick, T. A. (CoI), Camell, C. (CoI), Dong, X. (CoI), Garbe, J. R. (CoI), Griffin, T. J. (CoI), Hwang, J. (CoI), Ikramuddin, S. (CoI), Mashek, D. (CoI), Nelson, A. C. (CoI), Niedernhofer, L. J. (CoI), Pengo, T. (CoI), Revelo, X. (CoI), Robbins, P. D. (CoI), Sanders, M. A. (CoI), Sarver, A. L. (CoI), Seelig, D. (CoI), Sun, R. (CoI), Temiz, N. A. (CoI), Walmsley, S. J. (CoI), Wang, J. (CoI), Williams, J. W. (CoI), Bernlohr, D. A. (Prior Principal Investigator) & Aliferis, MD, PhD, C. (Other Role)

NIH NAT'L INSTITUTE ON AGING (NIA)

8/2/22 → 7/31/26

Project: Research project

Formaldehyde homeostasis and damage repair in a bacterial formaldehyde specialist

Bazurto, J. V. (PI)

NIH NIGMS NATL INST OF GENERAL

7/22/22 → 6/30/27

Project: Research project

Modeling Environmental Responses of Fanconi Anemia Epithelial Stem and Progenitor Cells to Prevent Squamous Cell Carcinoma

Ondrey, F. G. (PI)

FANCONI CANCER FOUNDATION

7/1/22 → 6/30/25

Project: Research project

The Interplay of ENDS and Tobacco Control Policy: Impact on the Population Harms of Tobacco

Stepanov, I. (PI) & Hatsukami, D. K. (CoI)

HEALTHPARTNERS INSTITUTE, NIH NATIONAL CANCER INSTITUTE (NCI)

7/1/22 → 6/30/27

Project: Research project

Bi-substrate Inhibitors of SARS-CoV-2 Nsp14 Methyltransferase

Chen, L. (PI), Geraghty, R. J. (CoI) & Xie, J. (CoI)

NIH Nat'l Inst of Allergy & Infect Dis

6/15/22 → 5/31/25

Project: Research project

Fecal Microbiome Transplant National Registry

Khoruts, A. (PI)

AMERICAN GASTROENTEROLOGICAL ASSOCIATION, NATIONAL INSTITUTES OF HEALTH (NIH)

5/16/22 → 4/30/25

Project: Research project

Multiplexed proteomics-based kinase assay development

Parker, L. L. (PI)

NIH NIGMS NATL INST OF GENERAL

5/1/22 → 4/30/26

Project: Research project

Fecal Microbiota Transplant (FMT)

Khoruts, A. (PI)

U.S. DEPARTMENT OF VETERANS AFFAIRS

3/1/22 → 2/28/26

Project: Research project

Role of the Cancer Epigenetics in Ethanol Blend Exposure

Hilakivi-Clarke, L. (PI)

UNIVERSITY OF MINNESOTA FOUNDATION

2/1/22 → 6/30/25

Project: Research project

FMT Collaboration

Khoruts, A. (PI) & Sadowsky, M. J. (CoI)

OPENBIOME

1/7/22 → 1/6/26

Project: Research project

Microbial Interactions in the Soybean Cyst Nematode Suppressive Soil Microbiome

Salomon, C. (PI)

USDA AGRICULTURAL RESEARCH SERVICE, USDA Nat'l Inst. of Food & Agriculture

10/1/21 → 5/31/25

Project: Research project

Biomarker phenotypes of air pollution and cancer risk in India

Stepanov, I. (PI), Hatsukami, D. K. (CoI), Hogan, C. (CoI), Khariwala, S. S. (CoI), Luo, X. (CoI) & Villalta, P. W. (CoI)

NIH NATL INST OF ENVIRON HEALTH SCIENCES

9/23/21 → 6/30/26

Project: Research project

Mass Spectrometric Analytical Collaborations with Members of the Carcinogenesis and Chemoprevention Program of the University of Minnesota Masonic Cancer Center

Villalta, P. W. (PI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/23/21 → 8/31/26

Project: Research project

High resolution mass spectrometric profile analysis of carcinogen-DNA adducts in oral cells of cigarette smokers and squamous cell carcinoma of the head and neck

Hecht, S. S. (PI), Hatsukami, D. K. (CoI), Khariwala, S. S. (CoI), Le, C. T. (CoI) & Luo, X. (Other Role)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/21/21 → 8/31/26

Project: Research project

Carcinogenesis and Chemoprevention

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