Biology of Aging Medical Discovery Team

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  • 2018

    ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes

    University of Washington Center for Mendelian Genomics & Niedernhofer, L. J., Feb 2018, In: Human mutation. 39, 2, p. 255-265 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • Fisetin is a senotherapeutic that extends health and lifespan

    Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T. & Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 2018, In: EBioMedicine. 36, p. 18-28 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    643 Scopus citations

  • Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung

    Dong, X., Shi, M., Lee, M., Toro, R., Gravina, S., Han, W., Yasuda, S., Wang, T., Zhang, Z., Vijg, J., Suh, Y. & Spivack, S. D., Mar 4 2018, In: Epigenetics. 13, 3, p. 264-274 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M. & Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., Jan 1 2018, In: Journal of Extracellular Vesicles. 7, 1, 1535750.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7750 Scopus citations

  • Multiple transcription factors contribute to inter-chromosomal interaction in yeast

    Dai, Y., Li, C., Pei, G., Dong, X., Ding, G., Zhao, Z., Li, Y. & Jia, P., Dec 21 2018, In: BMC Systems Biology. 12, 140.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F

    Shanbhag, N. M., Geschwind, M. D., DiGiovanna, J. J., Groden, C., Godfrey, R., Yousefzadeh, M. J., Wade, E. A., Niedernhofer, L. J., Malicdan, M. C. V., Kraemer, K. H., Gahl, W. A. & Toro, C., Jun 1 2018, In: Neurology: Genetics. 4, 3, e240.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Oxidation products of 5-methylcytosine are decreased in senescent cells andtissues of progeroid mice

    Zarakowska, E., Czerwinska, J., Tupalska, A., Yousefzadeh, M., Gregg, S. Q., Croix, C. M. S., Niedernhofer, L. J., Foksinski, M., Gackowski, D., Szpila, A., Starczak, M., Tudek, B. & Olinski, R., Jul 9 2018, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 8, p. 1003-1009 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Senolytics improve physical function and increase lifespan in old age

    Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D. & Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In: Nature Medicine. 24, 8, p. 1246-1256 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1516 Scopus citations

  • Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

    Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J. & Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In: Redox Biology. 17, p. 259-273 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    107 Scopus citations
  • 2017

    Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

    Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In: Aging cell. 16, 3, p. 480-487 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    87 Scopus citations

  • IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge

    Spadaro, O., Camell, C. D., Bosurgi, L., Nguyen, K. Y., Youm, Y. H., Rothlin, C. V. & Dixit, V. D., Apr 11 2017, In: Cell reports. 19, 2, p. 225-234 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    147 Scopus citations

  • Quantitative analysis of cellular senescence in culture and in Vivo

    Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St. Croix, C. M., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2017, In: Current protocols in cytometry. 2017, p. 9.51.1-9.51.25

    Research output: Contribution to journal › Article › peer-review

    16 Scopus citations
  • 2016

    Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

    Spadaro, O., Goldberg, E. L., Camell, C. D., Youm, Y. H., Kopchick, J. J., Nguyen, K. Y., Bartke, A., Sun, L. Y. & Dixit, V. D., Feb 23 2016, In: Cell reports. 14, 7, p. 1571-1580 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    75 Scopus citations
  • 2015

    IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

    Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In: European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Macrophage-specific de Novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and insulin resistance in obesity

    Camell, C. D., Nguyen, K. Y., Jurczak, M. J., Christian, B. E., Shulman, G. I., Shadel, G. S. & Dixit, V. D., Dec 4 2015, In: Journal of Biological Chemistry. 290, 49, p. 29402-29413 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    54 Scopus citations
  • 2014

    Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells

    Flores, R. R., Zhou, L. & Robbins, P. D., Aug 2014, In: Gene therapy. 21, 8, p. 715-722 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations
  • 2005

    Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma

    Mahidhara, R. S., Queiroz De Oliveira, P. E., Kohout, J., Beer, D. G., Lin, J., Watkins, S. C., Robbins, P. D. & Hughes, S. J., Feb 2005, In: Journal of Surgical Research. 123, 2, p. 302-311 10 p.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations