Biochemistry, Molecular Biology, and Biophysics (TMED)

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69 Active
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Active
An enabling approach for deep metaproteomic characterization of microbial contributors to tumorigenesis in clinical samples
Griffin, T. J. (PI) & Jagtap, P. D. (Co-Principal Investigator)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/1/25 → 3/31/28
Project: Research project
Regulation of tumor associated macrophage function by STAT5 in breast cancer
Schwertfeger, K. (PI), Farrar, M. A. (CoI), Muretta, J. M. (CoI), Nelson, A. C. (CoI), Bui, H. N. (Other Role), Haaning, A. M. (Other Role), He, Y. (Other Role) & Reese, L. E. (Other Role)
NIH NATIONAL CANCER INSTITUTE (NCI)
2/1/25 → 1/31/30
Project: Research project
The Role of Tcf7l2 in maintaining liver zonation and metabolic homeostasis
Mashek, D. (PI)
BOSTON CHILDREN'S HOSPITAL, NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
2/1/25 → 1/31/28
Project: Research project
Calmodulin and regulation of Cardiac Ryanodine Receptor and CaMKII
Rebbeck, R. T. (PI), Aldrich, C. (CoI), Svensson, B. (CoI), Thomas, D. D. (CoI), Solberg, J. C. (Other Role) & Yuen, S. L. (Other Role)
UNIVERSITY OF CALIFORNIA, DAVIS, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
1/1/25 → 11/30/28
Project: Research project
Uncovering the Microenvironment of Viral Transmission: An in situ Structural Biology Approach
Mendonca, L. (PI) & Sabino Cunha, M. (Other Role)
GILEAD SCIENCES, INC.
1/1/25 → 12/31/27
Project: Research project
Elucidating molecular mechanisms of PARP2 at R loops in myelodysplastic syndromes
McMahon, M. (PI)
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
1/1/25 → 12/31/25
Project: Research project
The KAPP-Sen Tissue Mapping Center Collaborative
Xu, M. (PI)
UNIVERSITY OF CONNECTICUT, NIH NAT'L INSTITUTE ON AGING (NIA)
12/17/24 → 8/31/26
Project: Research project
The synergistic benefits of metformin and senolytics on lifespan and healthspan
Xu, M. (PI), Guo, C. (Other Role), Wang, B. (Other Role) & Yan, P. (Other Role)
AMERICAN FEDERATION FOR AGING RESEARCH
12/16/24 → 12/31/25
Project: Research project
Lipid Metabolism, Mitochondrial Stress, and Senescence
Monroe, B. (PI)
NIH NAT'L INSTITUTE ON AGING (NIA)
9/30/24 → 9/29/25
Project: Research project
Molecular Characterization of Progressive Pulmonary Sarcoidosis
Griffin, T. J. (PI), Perlman, D. M. (CoI), Bailey, M. P. (Other Role), DeGrote, M. (Other Role), Goodwin, T. A. (Other Role), Hoff, I. N. (Other Role), Jagtap, P. D. (Other Role), Mehta, S. P. (Other Role), Noren, B. E. (Other Role) & Viken, K. J. (Other Role)
NATIONAL JEWISH HEALTH, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
9/1/24 → 8/31/25
Project: Research project
Mouse models for the influence of the social environment on health and aging
Bartolomucci, A. (PI) & Niedernhofer, L. J. (CoI)
NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/24 → 8/31/27
Project: Research project
Predictive Models of Beryllium Sensitization and Chronic Beryllium Disease
Griffin, T. J. (PI), Jagtap, P. D. (CoI), Hoff, I. N. (Other Role), Mehta, S. P. (Other Role), Noren, B. E. (Other Role) & Weise, D. O. (Other Role)
NATIONAL JEWISH HEALTH, NIH NATL INST OF ENVIRON HEALTH SCIENCES
9/1/24 → 8/31/25
Project: Research project
Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients
Griffin, T. J. (PI)
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
8/15/24 → 7/31/25
Project: Research project
Mechanisms of autophagy and mTOR signaling
Kim, D.-H. (PI)
NIH NIGMS NATL INST OF GENERAL
8/15/24 → 7/31/25
Project: Research project
Structural Biology Studies of a Large DNA Repair Complex
Latham, M. P. (PI)
NIH NIGMS NATL INST OF GENERAL
8/1/24 → 5/31/29
Project: Research project
A rigorous validation of a novel host-microbe peptide panel for ovarian cancer early detection from routinely collected clinical samples
Griffin, T. J. (PI), Jagtap, P. D. (CoI) & Petersen, A. J. (CoI)
MN OVARIAN CANCER ALLIANCE
7/1/24 → 6/30/26
Project: Research project
The immunoPeptidoGenomic (iPepGen) informatics resource for immuno-oncology research
Griffin, T. J. (PI) & Jagtap, P. D. (Co-Principal Investigator)
NIH NATIONAL CANCER INSTITUTE (NCI)
6/1/24 → 5/31/27
Project: Research project
Protein structural biophysics driving drug discovery for cardiac calcium transport regulation, producing translational advances and mechanistic insights
Thomas, D. D. (PI), Aldrich, C. (CoI) & Rebbeck, R. T. (CoI)
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
5/1/24 → 4/30/28
Project: Research project
Targeting Cellular Senescence to Extend Healthspan Core C: Senotherapeutic Drug Discovery and Development Core.
Robbins, P. D. (PI) & Niedernhofer, L. J. (CoI)
MAYO CLINIC ROCHESTER, NATIONAL INSTITUTES OF HEALTH (NIH)
5/1/24 → 1/31/29
Project: Research project
Structural and dynamic basis for PRKACA-dependent signalopathies
Veglia, G. (PI) & Thomas, D. D. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/1/24 → 3/31/29
Project: Research project
The role of senescent cells in dysregulating immune responses and pathogen control
Jameson, S. C. (PI), Camell, C. (CoI), Dong, X. (CoI), Hamilton Hart, S. E. (CoI), Masopust, D. (CoI), Niedernhofer, L. J. (CoI), Revelo, X. (CoI) & Robbins, P. D. (CoI)
NIH Nat'l Inst of Allergy & Infect Dis
3/11/24 → 2/28/29
Project: Research project
Cancer Center Support Grant
Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
2/1/24 → 1/31/29
Project: Research project
High-Throughput Laboratory Analysis of Tobacco-Related Biomarkers in Biospecimens: Serum and Urine Samples for Cotinine, Trans-3???-hydroxycotinine, 4-Methylnitrosamino-1-[3-pyridyl]-1-butanol (NNAL), and Total Nicotine Equivalents
Murphy, S. E. (PI)
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
9/25/23 → 3/24/27
Project: Research project
Project 1_Genetic variant-based drug discovery targeting conserved pathways of aging
Dong, X. (PI) & Zhang, L. (CoI)
ALBERT EINSTEIN COLLEGE OF MEDICINE, NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/23 → 8/31/25
Project: Research project
Frontiers in Alzheimer's and Aging Research (FrA2R)
Niedernhofer, L. J. (PI)
MAGEE-WOMENS RESEARCH INSTITUTE, NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/23 → 5/31/28
Project: Research project
Project 3: Genetic variant-based drug discovery targeting conserved pathways of aging
Niedernhofer, L. J. (PI)
ALBERT EINSTEIN COLLEGE OF MEDICINE, NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/23 → 8/31/28
Project: Research project
Core A: Genetic variant-based drug discovery targeting conserved pathways of aging
Robbins, P. D. (PI)
ALBERT EINSTEIN COLLEGE OF MEDICINE, NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/23 → 8/31/28
Project: Research project
Project 4: Genetic variant-based drug discovery targeting conserved pathways of aging
Robbins, P. D. (PI)
ALBERT EINSTEIN COLLEGE OF MEDICINE, NIH NAT'L INSTITUTE ON AGING (NIA)
9/1/23 → 8/31/28
Project: Research project
Translational Control by Human Pumilio Proteins
Goldstrohm, A. (PI)
NIH NIGMS NATL INST OF GENERAL
8/18/23 → 6/30/27
Project: Research project
AI-Driven Design of RF pulses for Enhancing Nuclear Magnetic Resonance Spectroscopy and Imaging
Veglia, G. (PI)
THE NATIONAL SCIENCE FOUNDATION
8/15/23 → 7/31/26
Project: Research project
Engineering Protein Modulators of Notch Activation for CAR T-cell immunotherapy
Muretta, J. M. (PI), Allred, J. R. (CoI) & Gordon, W. R. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
8/1/23 → 7/31/26
Project: Research project
Structural and molecular determinants of micro-Dystrophin stability and efficacyOption 2
Ervasti, J. M. (PI) & Muretta, J. M. (CoI)
SAREPTA THERAPEUTICS, INC.
7/1/23 → 3/31/26
Project: Research project
Mechanisms of cellular senescence driving intervertebral disc aging through local cell autonomous and systemic non-cell autonomous processes
Robbins, P. D. (PI) & Yousefzadeh, M. (Other Role)
UNIVERSITY OF PITTSBURGH, NIH NAT'L INSTITUTE ON AGING (NIA)
5/15/23 → 1/31/28
Project: Research project
The 11S-associated immunoproteasome in mitochondrial function and metabolic disorders
Kim, D.-H. (PI)
NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
5/5/23 → 4/30/27
Project: Research project
MARVEL: A Multidisciplinary Assessment of Risks from Vaping during Early Life
Murphy, S. E. (PI) & Stepanov, I. (CoI)
WAKE FOREST UNIVERSITY, NIH NATIONAL CANCER INSTITUTE (NCI)
5/3/23 → 4/30/28
Project: Research project
Skeletal muscle protein structural dynamics and function drive applications to drug discovery
Thomas, D. D. (PI), Cornea, R. L. (CoI), Lowe, D. A. (CoI) & Rebbeck, R. T. (Co-Principal Investigator)
NIH NIAMS NATL INST OF ARTHRIT
5/1/23 → 4/30/28
Project: Research project
Functional Multi-omics of Aging
Lowe, D. A. (PI), Arriaga, E. (CoI) & Niedernhofer, L. J. (CoI)
NIH NAT'L INSTITUTE ON AGING (NIA)
5/1/23 → 4/30/28
Project: Research project
Training Grant in Diabetes and Endocrinology to Enhance Metabolic Healthspan
Chow, L. S. (PI) & Bernlohr, D. A. (CoI)
NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
5/1/23 → 4/30/28
Project: Research project
Lipid droplets and the compartmentalization of subcellular metabolism
Mashek, D. (PI) & Puchner, E. (CoI)
NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
2/1/23 → 1/31/27
Project: Research project
Functional Dissection of Metabolic-Sensing Proline Hydroxylation Pathways
Chen, Y. (PI)
NIH NIGMS NATL INST OF GENERAL
2/1/23 → 1/31/29
Project: Research project
Molecular Signatures of Biologic Behavior in Pediatric Osteosarcoma
Makielski, K. M. (PI), Modiano, J. (CoI) & Robbins, P. D. (CoI)
NATIONAL INSTITUTES OF HEALTH (NIH)
2/1/23 → 11/30/27
Project: Research project
Targeting senescent astrocytes in age-accelerated murine tauopathy models
Niedernhofer, L. J. (PI)
MERCK, SHARP & DOHME LLC
1/31/23 → 1/31/26
Project: Research project
Targeting Oncogenic PELP1/SRC-3 Signaling Complexes in ER+ Breast Cancer
Truong, T. H. (PI)
NIH NATIONAL CANCER INSTITUTE (NCI)
1/1/23 → 12/31/25
Project: Research project
Role of adipose tissue inflammaging and metabolic dysfunction during sepsis
Camell, C. (PI)
NIH NAT'L INSTITUTE ON AGING (NIA)
12/1/22 → 11/30/27
Project: Research project
Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking
Hecht, S. S. (PI), Fujioka, N. (CoI), Hatsukami, D. K. (CoI), Henzler, C. (CoI), Murphy, S. E. (CoI), Stepanov, I. (CoI) & Tretyakova, N. Y. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
9/16/22 → 8/31/27
Project: Research project
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis Requirement title: Ahmed BLRD 2021-2024 Proteomics Service
Guerrero, C. R. (PI)
U.S. DEPARTMENT OF VETERANS AFFAIRS
8/19/22 → 8/18/25
Project: Research project
Microbiome-derived regulators of therapy-resistant colorectal tumors
Griffin, T. J. (PI), Jagtap, P. D. (CoI) & Subramanian, S. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
8/9/22 → 7/31/25
Project: Research project
Midwest Murine-Tissue Mapping Center (MM-TMC)
Robbins, P. D. (PI), Adeyi, O. (CoI), Bartolomucci, A. (CoI), Beckman, K. B. (CoI), Butterick, T. A. (CoI), Camell, C. (CoI), Dong, X. (CoI), Garbe, J. R. (CoI), Griffin, T. J. (CoI), Hwang, J. (CoI), Ikramuddin, S. (CoI), Mashek, D. (CoI), Nelson, A. C. (CoI), Niedernhofer, L. J. (CoI), Pengo, T. (CoI), Revelo, X. (CoI), Robbins, P. D. (CoI), Sanders, M. A. (CoI), Sarver, A. L. (CoI), Seelig, D. (CoI), Sun, R. (CoI), Temiz, N. A. (CoI), Walmsley, S. J. (CoI), Wang, J. (CoI), Williams, J. W. (CoI), Bernlohr, D. A. (Prior Principal Investigator) & Aliferis, MD, PhD, C. (Other Role)
NIH NAT'L INSTITUTE ON AGING (NIA)
8/2/22 → 7/31/26
Project: Research project
mRNA regulatory functions of the Drosophila TRIM-NHL protein, Brat
Goldstrohm, A. (PI)
NIH NIGMS NATL INST OF GENERAL
8/1/22 → 5/31/26
Project: Research project
Defining the interactions of senescent immune cells and skeletal cells
Robbins, P. D. (PI) & Niedernhofer, L. J. (CoI)
MAYO CLINIC ROCHESTER, NIH NAT'L INSTITUTE ON AGING (NIA)
6/1/22 → 3/31/27
Project: Research project