Addressing the challenge of tuberculosis in the animal-human interface

Organization profile

Organization profile

Zoonotic tuberculosis (TB), caused by M. bovis, is a major economic and human health concern in rural areas of the low- and middle-income countries, where the animal-human interface is intensifying as land use patterns change. Through an international and interdisciplinary approach, we will focus on addressing the world’s most successful pathogens and grand challenges unto themselves—Mycobacterium tuberculosis and Mycobacterium bovis. We will build on the existing international Minnesota-Mbarara collaborative initiative to enable investigations of interspecies transmission of tuberculosis in Uganda, aiming to decrease the systemic risk of the disease in both animal and human populations. Our team combines highly experienced and established scientists who are well versed in epidemiology, genomic and molecular epidemiology, molecular evolution, pathogenesis, and complex systems modeling. This application will target the Mycobacterium TB-complex group of organisms but is expected to have a major global impact on multiple zoonotic pathogens.

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    Projects

    Grand Challenges Research Awards: Phase 1

    1/1/171/1/19

    Project: Grand Challenges

    Research Output

    Complete genome sequencing of influenza A viruses within swine farrow-to-wean farms reveals the emergence, persistence, and subsidence of diverse viral genotypes

    Diaz, A., Marthaler, D., Culhane, M., Sreevatsan, S., Alkhamis, M. & Torremorell, M., Sep 1 2017, In : Journal of virology. 91, 18, e00745-17.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Differences in pathogenicity of three animal isolates of Mycobacterium species in a mouse model

    Dong, H., Lv, Y., Sreevatsan, S., Zhao, D. & Zhou, X., Aug 2017, In : PloS one. 12, 8, e0183666.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association

    Bannantine, J. P., Wu, C. W., Hsu, C., Zhou, S., Schwartz, D. C., Bayles, D. O., Paustian, M. L., Alt, D. P., Sreevatsan, S., Kapur, V. & Talaat, A. M., Mar 12 2012, In : BMC Genomics. 13, 1, 89.

    Research output: Contribution to journalArticle

  • 28 Scopus citations