Addressing the challenge of tuberculosis in the animal-human interface

Organization profile

Organization profile

Zoonotic tuberculosis (TB), caused by M. bovis, is a major economic and human health concern in rural areas of the low- and middle-income countries, where the animal-human interface is intensifying as land use patterns change. Through an international and interdisciplinary approach, we will focus on addressing the world’s most successful pathogens and grand challenges unto themselves—Mycobacterium tuberculosis and Mycobacterium bovis. We will build on the existing international Minnesota-Mbarara collaborative initiative to enable investigations of interspecies transmission of tuberculosis in Uganda, aiming to decrease the systemic risk of the disease in both animal and human populations. Our team combines highly experienced and established scientists who are well versed in epidemiology, genomic and molecular epidemiology, molecular evolution, pathogenesis, and complex systems modeling. This application will target the Mycobacterium TB-complex group of organisms but is expected to have a major global impact on multiple zoonotic pathogens.

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    Projects

    Grand Challenges Research Awards: Phase 1

    1/1/171/1/19

    Project: Grand Challenges

    Research Output

    Essential in vitro diagnostics for advanced HIV and serious fungal diseases: international experts’ consensus recommendations

    Bongomin, F., Govender, N. P., Chakrabarti, A., Robert-Gangneux, F., Boulware, D. R., Zafar, A., Oladele, R. O., Richardson, M. D., Gangneux, J. P., Alastruey-Izquierdo, A., Bazira, J., Boyles, T. H., Sarcarlal, J., Nacher, M., Obayashi, T., Worodria, W., Pasqualotto, A. C., Meya, D. B., Cheng, B., Sriruttan, C. & 6 others, Muzoora, C., Kambugu, A., Rodriguez Tudela, J. L., Jordan, A., Chiller, T. M. & Denning, D. W., Sep 1 2019, In : European Journal of Clinical Microbiology and Infectious Diseases. 38, 9, p. 1581-1584 4 p.

    Research output: Contribution to journalEditorial

    Open Access
    5 Scopus citations

    Molecular epidemiology of Mycoplasma hyorhinis porcine field isolates in the United States

    Clavijo, M. J., Sreevatsan, S., Johnson, T. J. & Rovira, A., 2019, In : PloS one. 14, 10, e0223653.

    Research output: Contribution to journalArticle

    Open Access
  • Complete genome sequencing of influenza A viruses within swine farrow-to-wean farms reveals the emergence, persistence, and subsidence of diverse viral genotypes

    Diaz, A., Marthaler, D., Culhane, M., Sreevatsan, S., Alkhamis, M. & Torremorell, M., Sep 1 2017, In : Journal of virology. 91, 18, e00745-17.

    Research output: Contribution to journalArticle

    Open Access
  • 14 Scopus citations