Addressing the challenge of tuberculosis in the animal-human interface

Organization profile

Organization profile

Zoonotic tuberculosis (TB), caused by M. bovis, is a major economic and human health concern in rural areas of the low- and middle-income countries, where the animal-human interface is intensifying as land use patterns change. Through an international and interdisciplinary approach, we will focus on addressing the world’s most successful pathogens and grand challenges unto themselves—Mycobacterium tuberculosis and Mycobacterium bovis. We will build on the existing international Minnesota-Mbarara collaborative initiative to enable investigations of interspecies transmission of tuberculosis in Uganda, aiming to decrease the systemic risk of the disease in both animal and human populations. Our team combines highly experienced and established scientists who are well versed in epidemiology, genomic and molecular epidemiology, molecular evolution, pathogenesis, and complex systems modeling. This application will target the Mycobacterium TB-complex group of organisms but is expected to have a major global impact on multiple zoonotic pathogens.

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Brucella abortus Medicine & Life Sciences
Mycobacterium Infections Medicine & Life Sciences
Immunity Medicine & Life Sciences
Mycobacterium bovis Medicine & Life Sciences
Milk Medicine & Life Sciences
Tuberculosis Medicine & Life Sciences
Polymerase Chain Reaction Medicine & Life Sciences
Tuberculosis Vaccines Medicine & Life Sciences

Projects 2017 2019

Grand Challenges Research Awards: Phase 1

1/1/171/1/19

Project: Grand Challenges

Research Output 2000 2011

60 Citations (Scopus)

Tuberculosis immunity: Opportunities from studies with cattle

Waters, W. R., Palmer, M. V., Thacker, T. C., Davis, W. C., Sreevatsan, S., Coussens, P., Meade, K. G., Hope, J. C. & Estes, D. M., Feb 1 2011, In : Clinical and Developmental Immunology. 2011, 768542.

Research output: Contribution to journalReview article

Immunity
Tuberculosis
Tuberculosis Vaccines
Bovine Tuberculosis
T-Lymphocytes

A multiplex approach to molecular detection of Brucella abortus and/or Mycobacterium boris infection in cattle

Sreevatsan, S., Bookout, J. B., Ringpis, F., Perumaalla, V. S., Ficht, T. A., Adams, L. G., Hagius, S. D., Elzer, P. H., Bricker, B. J., Kumar, G. K., Rajasekhar, M., Isloor, S. & Barathur, R. R., Aug 7 2000, In : Journal of clinical microbiology. 38, 7, p. 2602-2610 9 p.

Research output: Contribution to journalArticle

Brucella abortus
Mycobacterium Infections
Milk
Mycobacterium bovis
Polymerase Chain Reaction