Addressing the challenge of tuberculosis in the animal-human interface

Organization profile

Organization profile

Zoonotic tuberculosis (TB), caused by M. bovis, is a major economic and human health concern in rural areas of the low- and middle-income countries, where the animal-human interface is intensifying as land use patterns change. Through an international and interdisciplinary approach, we will focus on addressing the world’s most successful pathogens and grand challenges unto themselves—Mycobacterium tuberculosis and Mycobacterium bovis. We will build on the existing international Minnesota-Mbarara collaborative initiative to enable investigations of interspecies transmission of tuberculosis in Uganda, aiming to decrease the systemic risk of the disease in both animal and human populations. Our team combines highly experienced and established scientists who are well versed in epidemiology, genomic and molecular epidemiology, molecular evolution, pathogenesis, and complex systems modeling. This application will target the Mycobacterium TB-complex group of organisms but is expected to have a major global impact on multiple zoonotic pathogens.

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Paratuberculosis Medicine & Life Sciences
Mycobacterium avium Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences
Mutation Medicine & Life Sciences
Mycobacterium avium subsp. paratuberculosis Medicine & Life Sciences
Influenza A virus Medicine & Life Sciences
paratuberculosis Agriculture & Biology
Polymerase Chain Reaction Medicine & Life Sciences

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Projects 2017 2019

Grand Challenges Research Awards: Phase 1


Project: Grand Challenges

Research Output 1996 2017

8 Citations (Scopus)

Complete genome sequencing of influenza A viruses within swine farrow-to-wean farms reveals the emergence, persistence, and subsidence of diverse viral genotypes

Diaz, A., Marthaler, D., Culhane, M. R., Sreevatsan, S., Alkhamis, M. & Torremorell, M., Sep 1 2017, In : Journal of virology. 91, 18, e00745-17.

Research output: Contribution to journalArticle

Influenza A virus
54 Citations (Scopus)

Consensus-based reporting standards for diagnostic test accuracy studies for paratuberculosis in ruminants

Gardner, I. A., Nielsen, S. S., Whittington, R. J., Collins, M. T., Bakker, D., Harris, B., Sreevatsan, S., Lombard, J. E., Sweeney, R., Smith, D. R., Gavalchin, J. & Eda, S., Aug 1 2011, In : Preventive Veterinary Medicine. 101, 1-2, p. 18-34 17 p.

Research output: Contribution to journalArticle

Routine Diagnostic Tests
diagnostic techniques
7 Citations (Scopus)

Monoclonal antibodies bind a SNP-sensitive epitope that is present uniquely in Mycobacterium avium subspecies paratuberculosis

Bannantine, J. P., Stabel, J. R., Lamont, E. A., Briggs, R. E. & Sreevatsan, S., Jan 1 2011, In : Frontiers in Microbiology. 2, JULY

Research output: Contribution to journalArticle

Mycobacterium avium subsp. paratuberculosis
Single Nucleotide Polymorphism
Monoclonal Antibodies