Description
Abstract
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MatLab scripts used for the CHESCA and CONCISE analysis. The chemical shift lists were obtained using standard NMR experiments (1H-15N -TROSY-HSQC). The MatLab scripts were used for the CHESCA and CONCISE analysis of the amide chemical shift. These files are part of a publication on Communication biology: "Defective Internal Allosteric Network Imparts Dysfunctional ATP/Substrate Binding Cooperativity in Oncogenic Chimera of Protein Kinase A"
Description
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) in the apo form, ATPgN- and ATPgN/PKI-form. The list files were obtained using standard 1H-15N -TROSY-HSQC NMR experiments on uniformly 15N labeled-protein. The MatLab scripts (coded by Manu) are used for the CHEmical Shift Covariance Analysis(CHESCA) and COordiNated ChemIcal Shifts bEhavior (CONCISE) analysis of the amide chemical shift and their variants like the communtyCHESCA and the communityCONCISE.
Funding information
Sponsorship: NIH GM 100310 to G.V
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MatLab scripts used for the CHESCA and CONCISE analysis. The chemical shift lists were obtained using standard NMR experiments (1H-15N -TROSY-HSQC). The MatLab scripts were used for the CHESCA and CONCISE analysis of the amide chemical shift. These files are part of a publication on Communication biology: "Defective Internal Allosteric Network Imparts Dysfunctional ATP/Substrate Binding Cooperativity in Oncogenic Chimera of Protein Kinase A"
Description
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) in the apo form, ATPgN- and ATPgN/PKI-form. The list files were obtained using standard 1H-15N -TROSY-HSQC NMR experiments on uniformly 15N labeled-protein. The MatLab scripts (coded by Manu) are used for the CHEmical Shift Covariance Analysis(CHESCA) and COordiNated ChemIcal Shifts bEhavior (CONCISE) analysis of the amide chemical shift and their variants like the communtyCHESCA and the communityCONCISE.
Funding information
Sponsorship: NIH GM 100310 to G.V
| Date made available | 2020 |
|---|---|
| Publisher | Data Repository for the University of Minnesota |
| Date of data production | Jul 2016 - Dec 2018 |