Comparisons of hypothalamic dysfunction between Huntingtonâ€™s Disease (HD) patients and rodent models of HD have not always yielded similar results. Cortisol levels in HD patients have been contradictory, with reports ranging from hypo- to hypercorticoidism of morning measurements. Initial reports of major elevations in circulating corticosterone levels in the R6/2 mouse model of HD have only been followed up in one other closely related model, the R6/1 mouse, and the results were not perfectly congruent. To determine if abnormal stress hormones were a characteristic of disease, we examined diurnal and stress-induced corticosterone levels in multiple HD mouse models.
|Date made available||2018|
|Publisher||Data Repository for the University of Minnesota|
Dubinsky, J. M. (Creator), Engeland, W. C. (Creator), Hamid, A. (Creator), Zacharoff, L. (Creator) (2018). Abnormal Recovery from Acute Stress in Huntingtons Disease Mice. Data Repository for the University of Minnesota. 10.13020/D6C105